scholarly journals Diagnostic value of Thallium-201 scintigraphy in differentiating malignant bone tumors from benign bone lesions

2015 ◽  
Vol 29 (8) ◽  
pp. 674-681 ◽  
Author(s):  
Ryota Inai ◽  
Takayoshi Shinya ◽  
Akihiro Tada ◽  
Shuhei Sato ◽  
Tomohiro Fujiwara ◽  
...  
Keyword(s):  
Bone Tumors ◽  
Diagnostic Value ◽  
Thallium 201 ◽  
Bone Lesions ◽  
Malignant Bone Tumors ◽  
Thallium 201 Scintigraphy

scholarly journals KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimickers

2020 ◽  
Author(s):  
Lucen Jiang ◽  
Jianghuan Liu ◽  
Qingzhu Wei ◽  
Yiyang Wang
Keyword(s):  
Bone Tumor ◽  
Bone Tumors ◽  
Diagnostic Value ◽  
Benign Tumors ◽  
Malignant Bone Tumor ◽  
Malignant Bone Tumors ◽  
Potential Marker ◽  
Tumors Of Bone ◽  
Bone Sarcomas ◽  
Malignant And Benign Tumors

Abstract Background Karyopherin α 2 (KPNA2), a member of the Karyopherin α family, has been observed in several cancers but lack substantial investigation in malignant bone tumors. The purpose of the current study was to evaluate KPNA2 expression level and its utility as a novel diagnostic biomarker in osteosarcomas and their malignant bone tumor mimickers, such as chondrosarcomas and Ewing sarcomas.Method We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin embedded surgical specimens from 217 patients with malignant and benign tumors of bone, including 81 osteosarcomas, 42 chondrosarcomas, 9 Ewing sarcomas, 28 osteoid osteoma, 20 osteochondroma and 37 Chondroblastoma. Immunoreactivity was scored semi quantitatively based on stain extent and intensity.Results Seventy one of 81 (87.7%) osteosarcomas, zero of 42 (0%) chondrosarcomas and one of 9 (11.1%) Ewing sarcomas showed immunoreactivity for KPNA2. Negative KPNA2 expression was observed in all of benign bone tumors. Much more positive expression of KPNA2 was found in osteosarcomas as compared with chondrosarcomas and Ewing sarcomas. The sensitivity and specificity of KPNA2 immuno-expression for osteosarcoma was 87.7% and 100%, respectively. In several subtypes of osteosarcomas, immunohistochemical expression of KNA2 was more frequent in osteoblastic (94.5%), with 39 (70.9%) showing strong-intensity staining. KPNA2 positivity was observed in eleven of 13 (84.6%) chondroblastic, three of 6 (50%) fibroblastic, three of 4 (75%) telangiectatic and two of 3 (66.7%) giant cell-rich osteosarcoma. Stronger-intensity staining was observed in osteoblastic osteosarcoma.Conclusion KPNA2 is most frequently expressed in osteosarcomas, particularly in osteoblastic and chondroblastic tumors, but is rarely positive in chondrosarcomas and Ewing sarcomas. This feature may have diagnostic value since it is very useful for distinguishing between osteosarcomas and other bone sarcomas mimickers. This report supports KPNA2 as a novel marker for the diagnosis of osteosarcoma.

scholarly journals Diagnostic value of atrial pacing and thallium-201 scintigraphy for the assessment of patients with chest pain

1989 ◽  
Vol 12 (4) ◽  
pp. 193-201 ◽  
Author(s):  
H. G. Stratmann ◽  
A. L. Mark ◽  
K. E. Walter ◽  
G. A. Williams
Keyword(s):  
Chest Pain ◽  
Diagnostic Value ◽  
Thallium 201 ◽  
Atrial Pacing ◽  
Thallium 201 Scintigraphy

scholarly journals Diagnostic value of exercise thallium-201 scintigraphy for ischemic heart disease in patients with chronic renal failure.

1991 ◽  
Vol 24 (11) ◽  
pp. 1453-1461
Author(s):  
Shigeaki Sato ◽  
Makoto Ohta ◽  
Michimasa Soejima ◽  
Hiroshi Tanaka ◽  
Kenichi Sugimoto ◽  
...  
Keyword(s):  
Renal Failure ◽  
Heart Disease ◽  
Chronic Renal Failure ◽  
Ischemic Heart Disease ◽  
Diagnostic Value ◽  
Thallium 201 ◽  
Ischemic Heart ◽  
Thallium 201 Scintigraphy

Nuclear Imaging of Bone Tumors: Thallium-201 Scintigraphy

2001 ◽  
Vol 05 (02) ◽  
pp. 177-182 ◽  
Author(s):  
Hisashi Sumiya ◽  
Junichi Taki ◽  
Takahiro Higuchi ◽  
Norihisa Tonami
Keyword(s):  
Bone Tumors ◽  
Nuclear Imaging ◽  
Thallium 201 ◽  
Thallium 201 Scintigraphy

Imaging of Pediatric Bone Tumors and Tumor-like Lesions

2021 ◽  
Vol 25 (01) ◽  
pp. 057-067
Author(s):  
Sinan Al-Qassab ◽  
Radhesh Lalam ◽  
Rajesh Botchu ◽  
Alberto Bazzocchi
Keyword(s):  
Bone Tumors ◽  
Pediatric Population ◽  
Bone Lesions ◽  
Malignant Bone Tumors ◽  
Neoplastic Lesions ◽  
Tumor Like Lesions

AbstractBone lesions are commonly seen when reporting pediatric skeletal imaging. Distinguishing aggressive from nonaggressive lesions is essential in making the diagnosis. Not all aggressive lesions are neoplastic; indeed, osteomyelitis frequently presents with aggressive appearances and is far more commonly seen in the pediatric population than neoplastic lesions. In this article, we discuss an approach for the diagnosis of pediatric bone tumors and tumor-like conditions. The most common pediatric benign and malignant bone tumors are discussed in more detail.

Scintigraphy with 99m Tc-Phosphonate and 67Gallium in Patients Suspected of Primary Bone Tumors

1982 ◽  
Vol 21 (04) ◽  
pp. 136-139 ◽  
Author(s):  
C.-J. Edeling
Keyword(s):  
Soft Tissue ◽  
Bone Scintigraphy ◽  
Primary Tumor ◽  
Bone Tumors ◽  
Whole Body ◽  
Skeletal Metastases ◽  
Malignant Bone Tumors ◽  
67Ga Scintigraphy ◽  
Primary Bone Tumors ◽  
Primary Bone

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

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