scholarly journals Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)

Author(s):  
Tadashi Watabe ◽  
Makoto Hosono ◽  
Seigo Kinuya ◽  
Takahiro Yamada ◽  
Sachiko Yanagida ◽  
...  

AbstractWe present the guideline for use of [211At] sodium astatide (NaAt) for targeted alpha therapy in clinical trials on the basis of radiation safety issues in Japan. This guideline was prepared by a study supported by the Ministry of Health, Labour, and Welfare, and approved by the Japanese Society of Nuclear Medicine on 8th Feb, 2021. The study showed that patients receiving [211At]NaAt do not need to be admitted to a radiotherapy room and outpatient treatment is possible. The radiation exposure from the patient is within the safety standards of the ICRP and IAEA recommendations for the general public and caregivers. Precautions for patients and their families, safety management associated with the use of [211At]NaAt, education and training, and disposal of medical radioactive contaminants are also included in this guideline. Treatment using [211At]NaAt in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection and evaluation methodology shown here are considered internationally useful as well.

2019 ◽  
Vol 33 (11) ◽  
pp. 787-805 ◽  
Author(s):  
Makoto Hosono ◽  
Hideharu Ikebuchi ◽  
Seigo Kinuya ◽  
Sachiko Yanagida ◽  
Yoshihide Nakamura ◽  
...  

Abstract We present the guideline for use of yttrium-90-labeled anti-P-cadherin antibody injection for radionuclide therapy in clinical trials on the basis of radiation safety issues in Japan. This guideline was prepared by a study supported by the Ministry of Health, Labour, and Welfare, and approved by the Japanese Society of Nuclear Medicine. Treatment using yttrium-90-labeled anti-P-cadherin antibody injection in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection shown here are considered internationally useful as well. Only the original Japanese version is the formal document.


2008 ◽  
Vol 1 (3) ◽  
pp. 240-250 ◽  
Author(s):  
Barry Allen ◽  
Chand Raja ◽  
Syed Rizvi ◽  
Peter Graham ◽  
John Kearsley

2013 ◽  
Vol 380-384 ◽  
pp. 4614-4618
Author(s):  
Wen Long Liu ◽  
Hong Zhang

Mechanical Safety is very important in safety production. Not only China, but all over the world, the machinery safety issues are still in study. Safety becomes more and more important nowadays. So, to ensure the mechanical safety is not ones responsibility but all society. Measures must be taken jointly by the government, social organizations, enterprises and technical institutes to maintain the machinery safe. Government should develop the safety standards, the same as certification for social organizations. For enterprises, they must ensure that mechanical products meet the safety requirements. Strengthen the safety management in production process is the responsible of technical institutes. Together through a series of measures to make the mechanical safety situation has a good development in China.


2013 ◽  
Vol 765-767 ◽  
pp. 291-294
Author(s):  
Wen Long Liu ◽  
Hong Zhang

Mechanical Safety is very important in safety production. Not only China, the machinery safety issues are still not optimistic. Safety becomes more and more important nowadays. So, to ensure the mechanical safety is not ones responsibility but all society. Measures must be taken jointly by the government, social organizations, enterprises and technical institutes to maintain the machinery safe. Government should develop the safety standards, the same as certification for social organizations. For enterprises, they must ensure that mechanical products meet the safety requirements. Strengthen the safety management in production process is the responsible of technical institutes. Together through a series of measures to make the mechanical safety situation has a good development in China.


2014 ◽  
Vol 3 ◽  
Author(s):  
Jörgen Elgqvist ◽  
Sofia Frost ◽  
Jean-Pierre Pouget ◽  
Per Albertsson

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