Hot Melt Extrusion: an Emerging Green Technique for the Synthesis of High-Quality Pharmaceutical Cocrystals

2020 ◽  
Author(s):  
Prabhakar S. Panzade ◽  
Giridhar R. Shendarkar ◽  
Deepak A. Kulkarni
Keyword(s):  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
High Quality ◽  
Pharmaceutical Cocrystals ◽  
Green Technique ◽  
Hot Melt

Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing

CrystEngComm ◽  
2014 ◽  
Vol 16 (17) ◽  
pp. 3573-3583 ◽  
Author(s):  
Hiren G. Moradiya ◽  
Muhammad T. Islam ◽  
Sheelagh Halsey ◽  
Mohammed Maniruzzaman ◽  
Babur Z. Chowdhry ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
High Quality ◽  
Dissolution Rates ◽  
Extrusion Processing ◽  
Hot Melt

High quality carbamazepine–trans–cinnamic acid cocrystals were produced by hot melt extrusion. The extruded cocrystals showed improved dissolution rates. In-line NIR showed that cocrystals were formed gradually along the mixing zones of the extruder.

scholarly journals Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing

2020 ◽  
Vol 22 (2) ◽  
pp. 540-549 ◽  
Author(s):  
Md Sadeque Hossain Mithu ◽  
Steven A. Ross ◽  
Bruce D. Alexander ◽  
Dennis Douroumis
Keyword(s):  
Solid State ◽  
Hot Melt Extrusion ◽  
Solvent Free ◽  
Continuous Processing ◽  
Melt Extrusion ◽  
High Quality ◽  
Pharmaceutical Salts ◽  
Hot Melt

Solvent-free, continuous processing of high-quality pharmaceutical salts through via hot-melt extrusion as an alternative to solvent based approaches.

scholarly journals Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion

2018 ◽  
Vol 551 (1-2) ◽  
pp. 241-256 ◽  
Author(s):  
David Walsh ◽  
Dolores R. Serrano ◽  
Zelalem Ayenew Worku ◽  
Atif M. Madi ◽  
Peter O'Connell ◽  
...  
Keyword(s):  
Spray Drying ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Pharmaceutical Cocrystals ◽  
Hot Melt
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