Role of Laboratory Parameters in Preoperatively Predicting Perforated Appendicitis

2021 ◽  
Author(s):  
Ayushi Vig ◽  
Kirtikumar J Rathod ◽  
Avinash Sukdev Jadhav ◽  
Manish Pathak ◽  
Rahul Saxena ◽  
...  
Keyword(s):  
Perforated Appendicitis ◽  
Laboratory Parameters

scholarly journals Role of pre-procedural laboratory parameters in predicting in stent restenosis of drug eluting stents

2018 ◽  
Vol 70 ◽  
pp. S42
Author(s):  
Zeeshan Ahmed Mumtaz ◽  
Avinash Ashok Guthe ◽  
Milind Phadke ◽  
Zohaib Shaikh ◽  
Ajay Umakant Mahajan ◽  
...  
Keyword(s):  
Drug Eluting Stents ◽  
Laboratory Parameters ◽  
Stent Restenosis ◽  
Drug Eluting ◽  
In Stent Restenosis

Improving the Role of CT in Diagnosing Perforated Appendicitis

2012 ◽  
Vol 19 (10) ◽  
pp. 1173-1174 ◽  
Author(s):  
Abraham H. Dachman
Keyword(s):  
Perforated Appendicitis

scholarly journals Association of HMGB1, S100A12 and IL-17A Expression with IVIG-Resistant Kawasaki Disease and Treatment Options

2020 ◽  
Author(s):  
Deying Liu ◽  
Pan Liu ◽  
Fan Liu ◽  
Wei Yin ◽  
Yan Ding
Keyword(s):  
Kawasaki Disease ◽  
Coronary Arteries ◽  
Adjunctive Therapy ◽  
Clinical Symptoms ◽  
Treatment Options ◽  
Poor Response ◽  
Serum Levels ◽  
Laboratory Parameters ◽  
Molecular Pattern

Abstract Background: Kawasaki disease (KD) is a medium vessel vasculitis of unknown aetiology that predominantly affecting coronary arteries. The damage-associated molecular pattern molecules (DAMPs) such as HMGB1, S100A12 and IL-17A have been reported to predict poor response to IVIG. Here, we explored the the role of HMGB1, S100A12 and IL-17A in the detection of intravenous immunoglobulin (IVIG)-resistant in KD patients, and to investigate the value of different adjunctive therapy.Method: 126 KD patients and as well as age- and sex-matched 16 febrile control subjects were enrolled in our study. The fresh peripheral blood were collected from KD patients and febrile controls, analyzed the demographic or clinical data and various laboratory parameters. We also measured changes in serum levels of IL-17A and mRNA expression levels of HMGB1 and S100A12 were tested in IVIG-resistant KD patients. Further we explored the association between coronary arteries lesions and different treatment options about IVIG retreatment, methylprednisolone and infliximab for IVIG-resistant KD patients. Result: Regarding laboratory parameters, KD individuals were found to have lower levels of lymphocyte(L)%, prealbumin, CD4+, CD8+ and higher levels of WBC, neutrophil (N)%, CRP, ESR, NT-proBNP, ALT, CD4+/CD8+ (P<0.05 or P<0.01). For KD group, the 53 IVIG-resistant patients had significantly higher levels of S100A12, HMGB1, serum IL-17A, N%, CRP, NT-proBNP, TBIL, ALT, AST and lower levels of L%, PLT (P<0.05 or P<0.01) in comparison to the IVIG-responsive patients. For patients with IVIG-resistant, IVIG retreatment, methylprednisolone or infliximab were used. Methylprednisolone showed better in improving clinical symptoms and CRP than the IVIG retreatment and infliximab (P> 0.05).Conclusion: IVIG-resistant was associated with overreaction of inflammation.The levels of HMGB1,S100A12 and IL-17A suggested to be reliable predictors for IVIG-resistant in KD. In addition, the adjunctive therapy of methylprednisolone and infliximab showed more effective in relieving clinical symptoms than IVIG retreatment.

scholarly journals ROLE OF HYPERBILIRUBINEMIA IN PREDICTON OF GANGRENOUS/PERFORATED APPENDICITIS

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Irfan Hussain Khan ◽  
Arun Bhargava
Keyword(s):  
Acute Appendicitis ◽  
Prospective Study ◽  
Bilirubin Level ◽  
Diagnostic Tool ◽  
Liver Enzymes ◽  
Serum Bilirubin ◽  
Perforated Appendicitis ◽  
Total Serum Bilirubin ◽  
Total Serum

Introduction: The aim of this study was to determine the role of hyperbilirubinemia as a new diagnostic tool for predictor of gangrenous / perforated appendicitis. Methods: Hospital based prospective study was conducted on 100 patients with perforated/gangrenous appendix Results: In acute appendicitis case out of 84 cases 26 cases bilirubin level was more than 1mg/dl, in gangrenous appendicitis out of 3 cases all cases bilirubin level was more than 1mg/dl and in perforated appendicitis out of 13 cases 12 cases bilirubin level was more than 1mg/dl Conclusion: It is concluded from present study that elevated total serum bilirubin without elevation of liver enzymes is a good indicator of appendicular perforation. Keywords: Perforation, Appendicitis, Bilirubin

scholarly journals Association of HMGB1, S100A12 and IL-17A Expression with Immunoglobulin-Resistant in Kawasaki Disease and the Comparisons Between Different Adjunctive Therapeutic Approaches

2022 ◽  
Author(s):  
Yang Zhou ◽  
Liu Pan ◽  
You-jun Yang ◽  
Shi-yu Li ◽  
Wei Yin ◽  
...  
Keyword(s):  
Adjunctive Therapy ◽  
Clinical Symptoms ◽  
Poor Response ◽  
Serum Levels ◽  
Ivig Treatment ◽  
Control Group ◽  
Laboratory Parameters ◽  
Methyl Prednisolone ◽  
Laboratory Variables

Abstract Objective: The DAMPs such as HMGB1, S100A12 and IL-17A have been reported to predict poor response to IVIG. The aim of this study was to analyze the role of HMGB1,S100A12 and IL-17A in the detection of inflammation in KD patients with IVIG-resistant, and to investigate the value of different adjunctive therapy.Method: This study enrolled 126 patients diagnosed with KD, as well as age-matched 16 febrile control subjects. The demographic or clinical data, laboratory parameter and blood sample were collected. Various laboratory parameters as predictive factors for IVIG-resistant were calculated. And the serum levels of IL-17A and mRNA expression levels of HMGB1 and S100A12 were tested in all patients. For patients with acute KD in IVIG-resistant, we studied the levels of laboratory variables when using of IVIG retreatment, methylprednisolone, infliximab for children patients. Result: The variance of laboratory parameters between the febrile control group and KD group were analyzed. Regarding laboratory parameters, KD individuals were found to have lower levels of L%, PA, CD4+, CD8+ and higher levels of WBC, N%, CRP, ESR, NT-proBNP, ALT, CD4+/CD8+ (P<0.05 or P<0.01). For KD group, the 53 IVIG-resistant patients had significantly higher levels of blood S100A12, HMGB1, serum IL-17A levels And N%, CRP, NT-pro BNP, TBIL, ALT, AST and lower levels of L%, PLT (P<0.05 or P<0.01) in comparison to the IVIG-responsive patients. For patients with acute KD in IVIG-resistant, after initial IVIG-treatment, the adjunctive therapy of IVIG, methyl prednisolone or infliximab were used, the inflammatory symptoms and laboratory inflammatory markers were improved when treated with those drugs. Conclusion: IVIG-resistant was associated with higher levels of HMGB1, S100A12, IL-17A, CRP, NT-pro BNP, TBIL, ALT, AST and lower levels of L%, PLT before IVIG, especially when combined, were useful predictors for IVIG-resistant in KD. In addition, the adjunctive therapy of methylprednisolone and infliximab showed more effective in relief clinical symptoms than IVIG retreatment.

Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome

2014 ◽  
Vol 0 (0) ◽  
Author(s):  
Hong Du ◽  
Jing Li ◽  
Hai-Tao Yu ◽  
Wei Jiang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Risk Model ◽  
Hemorrhagic Fever ◽  
Acute Stage ◽  
Predictive Values ◽  
Laboratory Parameters ◽  
Diagnostic Capability ◽  
Independent Risk Factors ◽  
Early Indicators

AbstractThe objective of this study was to explore the role of laboratory parameters as early indicators of severity and as effective predictors of prognosis in patients with hemorrhagic fever with renal syndrome (HFRS).A total of 356 patients were enrolled in this study and were divided into mild, moderate, severe and critical types according to the clinical classification of HFRS. The levels of 12 routinely tested laboratory parameters during the acute stage among the four types were compared. The predictive values of the laboratory parameters for prognosis were analyzed, and a risk model for prognosis based upon the parameters was constructed.The levels of white blood counts (WBC), platelets (PLT), aspartate aminotransferase (AST), albumin (ALB), blood urea nitrogen (BUN), serum creatinine (Scr), prothrombin time (PT) and activated partial thromboplastin time (APTT) demonstrated significant differences among the four types (p<0.001); WBC, AST, PT and fibrinogen (Fib) were major independent risk factors for death; WBC, AST, PT and Fib used in combination were better for predicting prognosis than single parameters used alone (p<0.001).Some routinely tested laboratory parameters can be beneficial as early indicators of severity of HFRS. Using a combination of WBC, AST, PT and Fib to predict the outcome in patients with HFRS exhibited acceptable diagnostic capability.

Sign in / Sign up

Export Citation Format

Share Document