Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome

2014 ◽  
Vol 0 (0) ◽  
Author(s):  
Hong Du ◽  
Jing Li ◽  
Hai-Tao Yu ◽  
Wei Jiang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Risk Model ◽  
Hemorrhagic Fever ◽  
Acute Stage ◽  
Predictive Values ◽  
Laboratory Parameters ◽  
Diagnostic Capability ◽  
Independent Risk Factors ◽  
Early Indicators

AbstractThe objective of this study was to explore the role of laboratory parameters as early indicators of severity and as effective predictors of prognosis in patients with hemorrhagic fever with renal syndrome (HFRS).A total of 356 patients were enrolled in this study and were divided into mild, moderate, severe and critical types according to the clinical classification of HFRS. The levels of 12 routinely tested laboratory parameters during the acute stage among the four types were compared. The predictive values of the laboratory parameters for prognosis were analyzed, and a risk model for prognosis based upon the parameters was constructed.The levels of white blood counts (WBC), platelets (PLT), aspartate aminotransferase (AST), albumin (ALB), blood urea nitrogen (BUN), serum creatinine (Scr), prothrombin time (PT) and activated partial thromboplastin time (APTT) demonstrated significant differences among the four types (p<0.001); WBC, AST, PT and fibrinogen (Fib) were major independent risk factors for death; WBC, AST, PT and Fib used in combination were better for predicting prognosis than single parameters used alone (p<0.001).Some routinely tested laboratory parameters can be beneficial as early indicators of severity of HFRS. Using a combination of WBC, AST, PT and Fib to predict the outcome in patients with HFRS exhibited acceptable diagnostic capability.

scholarly journals The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248957
Author(s):  
Jia-Ni Zou ◽  
Liu Sun ◽  
Bin-Ru Wang ◽  
You Zou ◽  
Shan Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Fibrosis ◽  
Pulmonary Inflammation ◽  
Albumin Level ◽  
Acute Stage ◽  
Clinical Classification ◽  
High Resolution Computed Tomography ◽  
Affected Area ◽  
Independent Risk Factors

The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately studied. AI-assisted chest high-resolution computed tomography (HRCT) was used to investigate the proportion of COVID-19 patients with pulmonary fibrosis, the relationship between the degree of fibrosis and the clinical classification of COVID-19, the characteristics of and risk factors for pulmonary fibrosis, and the evolution of pulmonary fibrosis after discharge. The incidence of pulmonary fibrosis in patients with severe or critical COVID-19 was significantly higher than that in patients with moderate COVID-19. There were significant differences in the degree of pulmonary inflammation and the extent of the affected area among patients with mild, moderate and severe pulmonary fibrosis. The IL-6 level in the acute stage and albumin level were independent risk factors for pulmonary fibrosis. Ground-glass opacities, linear opacities, interlobular septal thickening, reticulation, honeycombing, bronchiectasis and the extent of the affected area were significantly improved 30, 60 and 90 days after discharge compared with at discharge. The more severe the clinical classification of COVID-19, the more severe the residual pulmonary fibrosis was; however, in most patients, pulmonary fibrosis was improved or even resolved within 90 days after discharge.

scholarly journals Evaluation of Early Prognostic Factors of Mortality in Patients with Acute Pancreatitis: A Retrospective Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Wenzheng Zhang ◽  
Jiang Hu ◽  
Bihui Yao ◽  
Xvsheng Yang ◽  
Lei Song ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Clinical Investigation ◽  
Laboratory Data ◽  
Area Under The Curve ◽  
Red Cell ◽  
Cell Distribution ◽  
Multivariate Logistic Regression ◽  
Predictive Values ◽  
Independent Risk Factors ◽  
Early Indicators

Early and accurate assessment of severity in acute pancreatitis (AP) is of great importance to provide effective disease management and prevent mortality. In this study, we aim to evaluate early indicators that predict the mortality of AP. We retrospectively analyzed 24-hour clinical characteristics and laboratory data in 166 AP patients recruited between January 2014 and November 2015 in Baotou Central Hospital. In total, 18 patients did not survive the disease. Multivariate logistic regression showed that red cell distribution (RDW) (OR = 2.965, P=0.001) and creatinine (OR = 1.025, P=0.005) were early independent risk factors of AP mortality while albumin (OR = 0.920, P=0.032) levels reduced AP mortality. The corresponding optimal cut-off values were 14.45, 125.5, and 34.95, respectively. The positive predictive values of the AP mortality were 80.1%, 54.5%, and 69.5%. In combined measurement, the area under the curve of RDW, creatinine, and albumin was 0.964 (95% CI: 0.924 to 1.000, P<0.001). RDW ≥ 14.45%, creatinine ≥ 125.5 μmol/l, and albumin ≤ 34.95 g/l indicated a good predictive value for mortality in AP patients with a sensitivity of 100% and specificity of 64.2%. RDW, creatinine, and albumin may serve as early indicators for AP mortality which warrants further clinical investigation.

scholarly journals Estruturação de modelo de risco de degradação ambiental aplicado ao Município de Pacatuba-SE / Environmental Degradation Risk Model applied to Pacatuba Municipality, Sergipe State

2018 ◽  
Vol 28 (54) ◽  
pp. 674-685
Author(s):  
Felippe Pessoa De Melo ◽  
Douglas Vieira Gois ◽  
Cristiano Aprigio Dos Santos ◽  
Rosemeri Melo E Souza ◽  
Antonio José Teixeira Guerra
Keyword(s):  
Natural Resources ◽  
Environmental Degradation ◽  
Risk Model ◽  
Space Use ◽  
Coastal Areas ◽  
Environment Quality ◽  
Space Organization ◽  
Unstable Environment

A degradação dos recursos naturais é uma problemática cada vez mais preocupante na sociedade. Em áreas costeiras essa problemática se agrava, pois a intensa ocupação imobiliária aliada à fragilidade dos sistemas ambientais litorâneos gera cenários de extensas áreas degradadas, comprometendo a qualidade do ambiente. Nesse sentido, o presente trabalho tem como objetivo analisar o balanço morfodinâmico do município de Pacatuba-SE, tendo em vista a fragilidade de seus ambientes frente à crescente ocupação do território. Os procedimentos adotados foram baseados na metodologia proposta por Tricart (1977), que avalia a organização do espaço delimitando áreas para as diferentes alternativas de uso e ocupação, categorizando o ambiente em: meios estáveis, meios intergrades e meios instáveis. Na área em estudo, os principais impactos que catalisam a degradação do ambiente são: a remoção da cobertura vegetal e contaminação dos corpos hídricos. Ademais, destaca-se a importância da avaliação morfodinâmica dos ambientes costeiros, vista a importância de um adequado ordenamento do uso do espaço de acordo com seus graus de fragilidade.Palavras–chave: degradação ambiental, sociedade, pressões antrópicas.Abstract Natural resources degradation is a very worrying issue in our society. In coastal areas this problem is worse, due to the intense settlement, together with environmental systems fragility of these systems, creating landscapes of extense degraded areas, decreasing environment quality. Therefore, this article aims at analyzing Paracatuba Municipality morphodynamic balance, considering environmental fragility, taking into account the intense settlement of its territory. The methodology for reaching this target is based on Tricart (1977), who assesses a space organization, limiting areas for different alternatives of use and occupation, categorizing the environment in a stable environment, intergrade environment and unstable environment. In the study area, the main impacts which cause environmental degradation are vegetation clearing and hydric bodies contamination. In addition, it is outlined the role of environment coastal morphodynamic assessment, due to the importance of an adequate classification of the space use, according to the different fragility degrees.Keywords: environmental degradation, society, anthropic pressures.

Raiders Activity on the Market for Corporate Control as a Product of Coercive Entrepreneurship Evolution

2007 ◽  
pp. 80-92
Author(s):  
A. Kireev
Keyword(s):  
Corporate Control ◽  
Role Of Government ◽  
Market For Corporate Control ◽  
Basic Characteristics

The paper studies the problem of raiders activity on the market for corporate control. This activity is considered as a product of coercive entrepreneurship evolution. Their similarities and sharp distinctions are shown. The article presents the classification of raiders activity, discribes its basic characteristics and tendencies, defines the role of government in the process of its transformation.

ASPECTS IN BUILDING A COMPANY WEB-SITE AND ITS ROLE FOR THE DEVELOPMENT OF BUSINESS

2018 ◽  
pp. 117-124
Author(s):  
Petar Halachev ◽  
Victoria Radeva ◽  
Albena Nikiforova ◽  
Miglena Veneva
Keyword(s):  
Life Cycle ◽  
Web Site ◽  
The Internet ◽  
A Company ◽  
The Web ◽  
Design Construction ◽  
Made In ◽  
Site Types

This report is dedicated to the role of the web site as an important tool for presenting business on the Internet. Classification of site types has been made in terms of their application in the business and the types of structures in their construction. The Models of the Life Cycle for designing business websites are analyzed and are outlined their strengths and weaknesses. The stages in the design, construction, commissioning, and maintenance of a business website are distinguished and the activities and requirements of each stage are specified.

The Role of Different Aspects of Impulsivity as Independent Risk Factors for Substance Use Disorders in Patients with ADHD: A Review

2015 ◽  
Vol 8 (2) ◽  
pp. 119-133 ◽  
Author(s):  
Slobodin Ortal ◽  
van de Glind Geurt ◽  
Franck Johan ◽  
Berger Itai ◽  
Yachin Nir ◽  
...  
Keyword(s):  
Risk Factors ◽  
Substance Use ◽  
Substance Use Disorders ◽  
Independent Risk Factors

Creating with Constraints

2020 ◽  
Author(s):  
Robert Hasegawa
Keyword(s):  
Visual Art ◽  
Creative Activity ◽  
Georges Perec ◽  
Gyorgy Ligeti ◽  
Raymond Queneau ◽  
Art Forms ◽  
Musical Creativity ◽  
Process Constraints

Musicians have long framed their creative activity within constraints, whether imposed externally or consciously chosen. As noted by Leonard Meyer, any style can be viewed as an ensemble of constraints, requiring the features of the artwork to conform with accepted norms. Such received stylistic constraints may be complemented by additional, voluntary limitations: for example, using only a limited palette of pitches or sounds, setting rules to govern repetition or transformation, controlling the formal layout and proportions of the work, or limiting the variety of operations involved in its creation. This chapter proposes a fourfold classification of the limits most often encountered in music creation into material (absolute and relative), formal, style/genre, and process constraints. The role of constraints as a spur and guide to musical creativity is explored in the domains of composition, improvisation, performance, and even listening, with examples drawn from contemporary composers including György Ligeti, George Aperghis, and James Tenney. Such musical constraints are comparable to self-imposed limitations in other art forms, from film (the Dogme 95 Manifesto) and visual art (Robert Morris’s Blind Time Drawings) to the writings of authors associated with the Oulipo (Ouvroir de littérature potentielle) such as Georges Perec and Raymond Queneau.

scholarly journals Formation of an Export-Oriented Agricultural Economy and Regional Open Innovations

2021 ◽  
Vol 7 (1) ◽  
pp. 32
Author(s):  
Victor L. Shabanov ◽  
Marianna Ya Vasilchenko ◽  
Elena A. Derunova ◽  
Andrey P. Potapov
Keyword(s):  
Agricultural Economy ◽  
Institutional Management ◽  
Agricultural Exports ◽  
Modeling Methodology ◽  
Fixed Assets ◽  
Analysis Application ◽  
The Impact ◽  
The Relationship

The aim of the work is to find relevant indicators for assessing the relationship between investments in fixed assets in agriculture, gross output of the industry, and agricultural exports using tools for modeling the impact of innovation and investment development on increasing production and export potential in the context of the formation of an export-oriented agricultural economy. The modeling methodology and the proposed estimating and forecasting tools for diagnosing and monitoring the state of sectoral and regional innovative agricultural systems are used to analyze the relationship between investments in fixed assets in agriculture, gross output of the industry, and agricultural exports based on the construction of the classification of Russian regions by factors that aggregate these features to diagnose incongruence problems and to improve institutional management in regional innovative export-oriented agrosystems. Based on the results of the factor analysis application, an underestimated role of indicators of investment in agriculture, the intensity and efficiency of agricultural production, were established. Based on the results of the cluster analysis, the established five groups of regions were identified, with significant differences in the level of investment in agriculture, the volume of production of the main types of agricultural products, and the export and exported food. The research results are of practical value for use in improving institutional management when planning reforms and transformations of regional innovative agrosystems.

scholarly journals Genetic and epigenetic mechanisms in the development of congenital heart diseases

2021 ◽  
Vol 4 (2) ◽  
pp. e000196
Author(s):  
Yue Wu ◽  
Xiaosi Jin ◽  
Yuhao Zhang ◽  
Jing Zheng ◽  
Rulai Yang
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Gene Mutations ◽  
Morbidity And Mortality ◽  
Molecular Medicine ◽  
Epigenetic Mechanisms ◽  
Epigenetic Factors ◽  
Near Future

Congenital heart disease (CHD) is the most common of congenital cardiovascular malformations associated with birth defects, and it results in significant morbidity and mortality worldwide. The classification of CHD is still elusive owing to the complex pathogenesis of CHD. Advances in molecular medicine have revealed the genetic basis of some heart anomalies. Genes associated with CHD might be modulated by various epigenetic factors. Thus, the genetic and epigenetic factors are gradually accepted as important triggers in the pathogenesis of CHD. However, few literatures have comprehensively elaborated the genetic and epigenetic mechanisms of CHD. This review focuses on the etiology of CHD from genetics and epigenetics to discuss the role of these factors in the development of CHD. The interactions between genetic and epigenetic in the pathogenesis of CHD are also elaborated. Chromosome abnormalities and gene mutations in genetics, and DNA methylations, histone modifications and on-coding RNAs in epigenetics are summarized in detail. We hope the summative knowledge of these etiologies may be useful for improved diagnosis and further elucidation of CHD so that morbidity and mortality of children with CHD can be reduced in the near future.

Role of Laboratory Parameters in Preoperatively Predicting Perforated Appendicitis

2021 ◽  
Author(s):  
Ayushi Vig ◽  
Kirtikumar J Rathod ◽  
Avinash Sukdev Jadhav ◽  
Manish Pathak ◽  
Rahul Saxena ◽  
...  
Keyword(s):  
Perforated Appendicitis ◽  
Laboratory Parameters
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