Stem Cell-Based Cardiac Tissue Engineering

2011 ◽  
Vol 4 (5) ◽  
pp. 592-602 ◽  
Author(s):  
Sara S. Nunes ◽  
Hannah Song ◽  
C. Katherine Chiang ◽  
Milica Radisic
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering

Carbon nanotube doped pericardial matrix derived electroconductive biohybrid hydrogel for cardiac tissue engineering

2019 ◽  
Vol 7 (9) ◽  
pp. 3906-3917 ◽  
Author(s):  
Kaveh Roshanbinfar ◽  
Zahra Mohammadi ◽  
Abdorreza Sheikh-Mahdi Mesgar ◽  
Mohammad Mehdi Dehghan ◽  
Oommen P. Oommen ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Stem Cell ◽  
Carbon Nanotube ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Promising Material ◽  
Positively Charged

Biohybrid hydrogels consisting of solubilized nanostructured pericardial matrix and electroconductive positively charged hydrazide-conjugated carbon nanotubes provide a promising material for stem cell-based cardiac tissue engineering.

scholarly journals Tissue Engineering: Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue Engineering(Adv. Healthcare Mater. 13/2016)

2016 ◽  
Vol 5 (13) ◽  
pp. 1532-1532 ◽  
Author(s):  
Mahshid Kharaziha ◽  
Adnan Memic ◽  
Mohsen Akbari ◽  
David A. Brafman ◽  
Mehdi Nikkhah
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering

scholarly journals Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy

2016 ◽  
Vol 16 (7) ◽  
pp. 958-977 ◽  
Author(s):  
Anwarul Hasan ◽  
Renae Waters ◽  
Boustany Roula ◽  
Rahbani Dana ◽  
Seif Yara ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Enhance Stem Cell

scholarly journals Adipose-derived mesenchymal stem cell seeded Atelocollagen scaffolds for cardiac tissue engineering

2020 ◽  
Vol 31 (10) ◽  
Author(s):  
Qiong Li ◽  
Miaomiao Li ◽  
Meng Li ◽  
Zhengyan Zhang ◽  
Han Ma ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Subcutaneous Adipose Tissue ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Good Biocompatibility ◽  
Subcutaneous Adipose

Abstract ADMSCs were isolated from subcutaneous adipose tissue, characterized and cultured in vitro. GFP-labeled ADMSCs can grow and proliferate well on the Atelocollagen scaffolds, and induced by 5-aza the cells can differentiate into cardio-like cells. 3D cultured ADMSCs on Atelocollagen scaffolds were transplanted into mice ischemia myocardium, and have good biocompatibility with host cardio tissue.

scholarly journals Conductive silk–polypyrrole composite scaffolds with bioinspired nanotopographic cues for cardiac tissue engineering

2018 ◽  
Vol 6 (44) ◽  
pp. 7185-7196 ◽  
Author(s):  
Jonathan H. Tsui ◽  
Nicholas A. Ostrovsky-Snider ◽  
David M. P. Yama ◽  
Jordan D. Donohue ◽  
Jong Seob Choi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Silk Fibroin ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Human Stem Cell ◽  
Composite Scaffolds ◽  
Polypyrrole Composite

Imparting electroconductive and nanotopographical cues to biodegradable silk–fibroin films enhanced the maturation of cultured human stem cell-derived cardiomyocytes.

Nano-Enabled Approaches for Stem Cell-Based Cardiac Tissue Engineering

2016 ◽  
Vol 5 (13) ◽  
pp. 1533-1553 ◽  
Author(s):  
Mahshid Kharaziha ◽  
Adnan Memic ◽  
Mohsen Akbari ◽  
David A. Brafman ◽  
Mehdi Nikkhah
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering

Abstract P359: Electroconductive Scaffolds To Mature Induced Pluripotent Stem Cell-derived Cardiomyocytes For Cardiac Tissue Engineering

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Suh Hee T Cook ◽  
Jessica Gluck
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Cardiac Tissue ◽  
Induced Pluripotent Stem Cell ◽  
Cardiac Tissue Engineering ◽  
Patient Specific ◽  
Sem Images ◽  
Induced Pluripotent ◽  
Electrical Pacing

Heart disease is the leading cause of death worldwide. Cardiac tissue engineering (CTE) aims to repair and replace heart tissue, offering a solution. Induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) could revolutionize CTE due to their theoretical ability to supply limitless patient-specific CMs. However, iPSC-CMs are electrophysiologically immature compared to functional adult CMs, and therefore incapable of sustaining a heartbeat. Thus, a scaffold capable of electrophysiologically maturing iPSC-CMs is needed. My research increases the electroconductivity of electrospun (ES) scaffolds by incorporating carbon nanotubes (CNTs), which I hypothesize will mature iPSC-CMs seeded onto them due to their excellent electroconductive properties. Morphological, biocompatibility, and electrical analyses have been performed on ES polycaprolactone (PCL) and gelatin scaffolds with CNTs incorporated via a ‘sandwich’ and dual deposition method in order to increase electroconductivity. Morphological analyses were performed via ImageJ on SEM images. Fiber diameter and pore size quantification confirmed the ability to exert morphological control by modifying solution properties and ES parameters, which is crucial to achieve biomimicry of the cardiac extracellular matrix. Live/dead assays and immunofluorescence revealed the CNT scaffolds offer high biocompatibility for NIH 3T3 fibroblasts, which attach, proliferate, and migrate well. Electrical analysis performed with a multimeter and two-probe resistance measurement confirms that inclusion of CNTs significantly increases scaffold conductivity, moreso for dual deposition scaffolds than ‘sandwich’ ones, and moreso parallel to the CNT arrays than orthogonally. These results prove the feasibility of using such scaffolds as a method for in vitro electrophysiological iPSC-CM maturation. Next steps include optimization of scaffolds, analysis of iPSC-CM biocompatibility and response, and recapitulation and manipulation of the electrophysiology of cardiac tissue, including quantification of markers for cardiac function and maturity, and assessment of iPSC-CM + scaffold response to electrical pacing.

scholarly journals Cardiac tissue engineering using human stem cell-derived cardiomyocytes for disease modeling and drug discovery

2012 ◽  
Vol 9 (4) ◽  
pp. e219-e227 ◽  
Author(s):  
Irene C. Turnbull ◽  
Deborah K. Lieu ◽  
Ronald A. Li ◽  
Kevin D. Costa
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Drug Discovery ◽  
Cardiac Tissue ◽  
Disease Modeling ◽  
Cardiac Tissue Engineering ◽  
Human Stem Cell
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