scholarly journals Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study

2017 ◽  
Vol 10 (5-6) ◽  
pp. 489-498 ◽  
Author(s):  
Noel Conlisk ◽  
Rachael O. Forsythe ◽  
Lyam Hollis ◽  
Barry J. Doyle ◽  
Olivia M.B. McBride ◽  
...  
Author(s):  
John H. Ashton ◽  
James A. M. Mertz ◽  
Megan J. Alexander ◽  
Marvin J. Slepian ◽  
Joseph L. Mills ◽  
...  

The preferred method to treat abdominal aortic aneurysms (AAAs) is endovascular repair with a stent-graft (EVAR). Although EVAR is fairly successful, there are several challenges to address, which include patient ineligibility due to complex anatomy and long-term failure due to migration and endoleak. Drug treatments that reduce or halt AAA growth are also currently under investigation [1].


2014 ◽  
Vol 21 (4) ◽  
pp. 556-564 ◽  
Author(s):  
Philipp Erhart ◽  
Caspar Grond-Ginsbach ◽  
Maani Hakimi ◽  
Felix Lasitschka ◽  
Susanne Dihlmann ◽  
...  

Author(s):  
John H. Ashton ◽  
Darren G. Haskett ◽  
Jonathan P. Vande Geest

An intraluminal thrombus (ILT) forms along the inner layer of the aorta in 75% of abdominal aortic aneurysms (AAAs) [1] and can often times cover a large surface area of the AAA wall. Mechanical modeling of the ILT is essential in many AAA studies. For example, inclusion of the ILT in rupture risk models significantly affects the estimated stress acting on the aneurysmal wall [2]. In addition, using ILT mechanical properties to model fluid flow through the ILT is critical to developing an intraluminal drug delivery treatment of AAAs to ensure the drug reaches the aneurysmal wall.


Author(s):  
Evelyne van Dam ◽  
Marcel Rutten ◽  
Frans van de Vosse

Rupture risk of abdominal aortic aneurysms (AAA) based on wall stress analysis may be superior to the currently used diameter-based rupture risk prediction [4; 5; 6; 7]. In patient specific computational models for wall stress analysis, the geometry of the aneurysm is obtained from CT or MR images. The wall thickness and mechanical properties are mostly assumed to be homogeneous. The pathological AAA vessel wall may contain collageneous areas, but also calcifications, cholesterol crystals and large amounts of fat cells. No research has yet focused yet on the differences in mechanical properties of the components present within the degrading AAA vessel wall.


Author(s):  
S. De Bock ◽  
F. Iannaccone ◽  
M. De Beule ◽  
G. De Santis ◽  
F. Vermassen ◽  
...  

Stent grafts are endovascular devices, used for minimally invasive treatment of abdominal aortic aneurysms. Although the outcome of the procedure is often successful, it is still associated with some longer term problems — especially for complex cases with geometrically challenging aneurysm geometries. An increasing number of devices, with widely varying design features, have entered the market, creating a need to investigate and compare the available treatment options.


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