5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen isolated from Angelica dahurica inhibits cyclooxygenase-2 and 5-Lipoxygenase in mouse bone marrow-derived mast cells

2008 ◽  
Vol 31 (5) ◽  
pp. 617-621 ◽  
Author(s):  
Jin Mei Hua ◽  
Tae Chul Moon ◽  
Tae Gyun Hong ◽  
Kyong Min Park ◽  
Jong Keun Son ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
Cyclooxygenase 2 ◽  
Mouse Bone Marrow ◽  
Angelica Dahurica

Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells

2006 ◽  
Vol 29 (10) ◽  
pp. 874-878 ◽  
Author(s):  
Se Jong Kim ◽  
Meihua Jin ◽  
Eunkyung Lee ◽  
Tae Chul Moon ◽  
Zhejiu Quan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Arachidonic Acid ◽  
Mast Cells ◽  
Cyclooxygenase 2 ◽  
Mouse Bone Marrow ◽  
Methyl Gallate ◽  
Metabolizing Enzymes

Meso-dihydroguaiaretic acid isolated from Saururus chinensis inhibits cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells

2008 ◽  
Vol 31 (5) ◽  
pp. 606-610 ◽  
Author(s):  
Tae Chul Moon ◽  
Chang Seob Seo ◽  
Kyungmi Haa ◽  
Jin Cheul Kim ◽  
Nam Kyung Hwang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
Cyclooxygenase 2 ◽  
Mouse Bone Marrow ◽  
Saururus Chinensis

Regulation of proliferation of mouse bone marrow-derived mast cells by activated fibroblasts

1996 ◽  
Vol 19 (5) ◽  
pp. 368-373
Author(s):  
Sung-Joo Park ◽  
Hyung-Ryong Kim ◽  
Hye-Won Cho ◽  
Hyung-Min Kim
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
Mouse Bone Marrow ◽  
Regulation Of Proliferation ◽  
Activated Fibroblasts

scholarly journals The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase.

1995 ◽  
Vol 182 (1) ◽  
pp. 197-206 ◽  
Author(s):  
M Murakami ◽  
K F Austen ◽  
J P Arm
Keyword(s):  
Bone Marrow ◽  
Arachidonic Acid ◽  
Mast Cells ◽  
Cell Membrane ◽  
Phospholipase A2 ◽  
Mouse Bone Marrow ◽  
Kit Ligand ◽  
Cytosolic Phospholipase ◽  
Delayed Phase ◽  
Stimulation Of

c-kit ligand (KL) activated mouse bone marrow-derived mast cells (BMMC) for the dose- and time-dependent release of arachidonic acid from cell membrane phospholipids, with generation of leukotriene (LT) C4 in preference to prostaglandin (PG)D2. KL at concentrations of 10 ng/ml elicited half-maximal eicosanoid generation and at concentrations of > 50 ng/ml elicited a maximal generation of approximately 15 ng LTC4 and 1 ng PGD2 per 10(6) cells, with 20% net beta-hexosaminidase release 10 min after stimulation. Of the other cytokines tested, none, either alone or in combination with KL, elicited or modulated the immediate phase of mediator release by BMMC, indicating strict specificity for KL. Activation of BMMC in response to KL was accompanied by transient phosphorylation of cytosolic phospholipase A2 and reversible translocation of 5-lipoxygenase to a cell membrane fraction 2-5 min after stimulation, when the rate of arachidonic acid release and LTC4 production were maximal. BMMC continuously exposed to KL in the presence of IL-10 and IL-1 beta generated LTC4 in marked preference to PGD2 over the first 10 min followed by delayed generation of PGD2 with no LTC4 over several hours. Pharmacologic studies revealed that PGD2 generation in the immediate phase depended on prostaglandin endoperoxide synthase (PGHS)-1 and in the delayed phase on PGHS-2. Thus, KL provided a nonallergic stimulus for biphasic eicosanoid generation by mast cells. The immediate phase is dominated by LTC4 generation with kinetics and postreceptor biosynthetic events similar to those observed after cell activation through the high affinity IgE receptor, whereas the delayed phase of slow and selective PGD2 production is mediated by induction of PGHS-2.

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