Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells

2012 ◽  
Vol 35 (11) ◽  
pp. 1989-1998 ◽  
Author(s):  
Bo Ra Ahn ◽  
Hye Eun Moon ◽  
Hyeung Rak Kim ◽  
Hyun Ah Jung ◽  
Jae Sue Choi
Keyword(s):  
Pc12 Cells ◽  
Amyloid Beta ◽  
Brown Alga ◽  
Neuroprotective Effect ◽  
Amyloid Beta Peptide ◽  
Eisenia Bicyclis ◽  
Beta Peptide

scholarly journals Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 Cells

2004 ◽  
Vol 90 (3) ◽  
pp. 567-575 ◽  
Author(s):  
Rita M. Ramalho ◽  
Paulo S. Ribeiro ◽  
Susana Sola ◽  
Rui E. Castro ◽  
Clifford J. Steer ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Tauroursodeoxycholic Acid ◽  
Beta Peptide ◽  
Induced Apoptosis

scholarly journals Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 142 ◽  
Author(s):  
Caiyun Zhang ◽  
Xingming Zhao ◽  
Shiqi Lin ◽  
Fangyuan Liu ◽  
Jiahui Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Neuroprotective Effect ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
Amyloid Beta Peptide ◽  
Nuclear Factor ◽  
Beta Peptide

ent-Kaur-15-en-17-al-18-oic acid, extracted from the Chinese well known folk herb Leontopodium longifolium, performed a significantly neuroprotective effect on amyloid beta peptide 25-35 (Aβ25-35)-induced SH-SY5Y cells neurotoxicity in Alzheimer’s disease. The results demonstrated that this compound maintained oxidative stress balance, reduced levels of reactive oxygen species (ROS), malondialdehyde (MDA), and improved contents of glutathione (GSH) and superoxide dismutase (SOD) without obvious cytotoxicity. This compound also obviously relieved oxidative stress-induced apoptosis associated with p53 and nuclear factor κB (NF-κB) pathways accompanied by upregulating B-cell lymphoma-2 (bcl-2) and downregulating p53, nuclear factor κB (NF-κB), Bax, Cleaved-caspase 3, and Cytochrome C protein expressions further. Briefly, ent-kaur-15-en-17-al-18-oic acid protected cells from oxidative apoptosis associated with p53 and NF-κB pathways.

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