scholarly journals Synthesis and in vitro antimicrobial activity screening of new pipemidic acid derivatives

2018 ◽  
Vol 41 (6) ◽  
pp. 633-645 ◽  
Author(s):  
Łukasz Popiołek ◽  
Anna Biernasiuk ◽  
Kinga Paruch ◽  
Anna Malm ◽  
Monika Wujec
Keyword(s):  
Antimicrobial Activity ◽  
Pipemidic Acid ◽  
In Vitro Antimicrobial Activity ◽  
Activity Screening

scholarly journals In vitro antimicrobial activity screening of new Heterocyclic compounds derived from 5-bromo-2,3-di(furan-2-yl)-1h-indole

2021 ◽  
pp. 889-893
Author(s):  
Hana A. A. Mageed ◽  
Reda F. El- Ezabi ◽  
Fayrouz A. Khaled
Keyword(s):  
Antimicrobial Activity ◽  
Heterocyclic Compounds ◽  
In Vitro Antimicrobial Activity ◽  
High Antibacterial Activity ◽  
Pharmaceutical Application ◽  
Three Component Reaction ◽  
Activity Screening ◽  
Bacteria And Fungi ◽  
New Compounds

This article describes the antimicrobial activity evaluation of new heterocyclic compounds derived from 5-bromo-2,3-di(furan-2-yl)-1h-indole. Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively attached to produce novel drugs. New compounds were obtained on the basis of derivatives including 1H-indole-2,3-dione derivatives. Acid-catalyzed, three-component reaction (Belinelli synthesis) between 5-bromo-2,3-di(furan-2-yl)1H-indole, acetylacetone and semi carbazide, thiosemicarbazone, urea, thiourea, guanidine constitutes a rapid and facile synthesis of corresponding tetrahydro pyrimidines, which are interesting compounds with a potential for pharmaceutical application. Antimicrobial tests revealed high antibacterial activity of obtained derivatives. The synthesized compounds have been screened for their in vitro antimicrobial activity against various strains of bacteria and fungi. Keywords: Vitro; Heterocyclic Compounds; Antimicrobial

Chemical Composition and in-vitro antimicrobial screening of leaf essential oil of Plectranthus gerardianus Benth., and isolation of the major constituent of oil

2020 ◽  
Vol 10 ◽  
Author(s):  
Navadha Bhatt ◽  
Navabha Joshi ◽  
Kapil Ghai ◽  
Om Prakash
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Major Constituent ◽  
In Vitro Antimicrobial Activity ◽  
Gram Positive Bacteria ◽  
Medicinal Value ◽  
Leaf Essential Oil ◽  
Plant Families ◽  
Total Oil

Background: The Lamiaceae (Labiatae) is one of the most diverse and widespread plant families’ in terms of ethno medicine and its medicinal value is based on the volatile oils concentration. This family is important for flavour, fragrance and medicinal properties. Manyplants belonging to this family have indigenous value. Method: The essential oil of Plectranthus gerardianusBenth. (Lamiaceae), was analysed by GC and GC-MS analysis, while the major component was isolated and conformed by NMR spectroscopy. Result: The oil was found to be rich in oxygenated monoterpenes, which contribute around 62% of the total oil. The major components identified were fenchone (22.90%) and carvenone oxide (16.75%), besides other mono and sesquiterpenoids. The in-vitro antimicrobial activity of essential oil was tested against three gram negative bacteria viz. Pasteurellamultocida, Escherichia coli, and Salmonella enterica, two gram positive bacteria viz. Staphylococcus aureus and Bacillus subtilis and two fungi viz. Candida albicans and Aspergillusflavus. The antimicrobial activity of the oil was also compared to the antimicrobial activity of leaf essential oil of another Himalayan plant viz. Nepetacoerulescens. Conclusion: The oil showed in-vitro antimicrobial activity against all the microbial strains and can lessen the ever-growing demand of potentially hazardous antibiotics for treatment.

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