Self-assembly nanomicelle-microneedle patches with enhanced tumor penetration for superior chemo-photothermal therapy

Nano Research ◽  
2021 ◽  
Author(s):  
Ying Sun ◽  
Minglong Chen ◽  
Dan Yang ◽  
Wanbing Qin ◽  
Guilan Quan ◽  
...  
2020 ◽  
Vol 30 (11) ◽  
pp. 1906309 ◽  
Author(s):  
Cunfeng Song ◽  
Yugang Li ◽  
Tianliang Li ◽  
Yuming Yang ◽  
Zhicheng Huang ◽  
...  

2020 ◽  
Vol 92 (24) ◽  
pp. 16113-16121
Author(s):  
Anna Wang ◽  
Qiulian Mao ◽  
Meng Zhao ◽  
Shuyue Ye ◽  
Jing Fang ◽  
...  

Drug Delivery ◽  
2020 ◽  
Vol 27 (1) ◽  
pp. 378-386 ◽  
Author(s):  
Haipeng Xu ◽  
Lin Dong ◽  
Zhang Bin ◽  
Huo Yansong ◽  
Lin Shaofeng ◽  
...  

Theranostics ◽  
2014 ◽  
Vol 4 (9) ◽  
pp. 904-918 ◽  
Author(s):  
Heng Deng ◽  
Yanqi Zhong ◽  
Meihong Du ◽  
Qinjun Liu ◽  
Zhanming Fan ◽  
...  

Theranostics ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. 2177-2185 ◽  
Author(s):  
Zhen Yang ◽  
Jibin Song ◽  
Yunlu Dai ◽  
Jingyi Chen ◽  
Feng Wang ◽  
...  

2020 ◽  
Author(s):  
Yuyang Miao ◽  
Shibo Lv ◽  
Daoyuan Zheng ◽  
Yuhan Liu ◽  
Dapeng Liu ◽  
...  

Abstract Porphyrin-based metal coordination polymers (MCPs) have attracted numerous attention due to their great promise application in phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT). However, the detailed self-assembly process of porphyrin-based MCPs still remains poorly understood. This work provides a detailed study of the self-assembly process of MCPs constructed by Mn2+ and TCPP (TCPP: 4,4′,4′′,4′′′-(Porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid)) in aqueous solution. Unlike traditional nucleation and growth mechanism, we discover that there is a metastable metal-organic intermediate which is kinetically favored in the self-assembly process. And the metastable metal-organic intermediate nanotape structures could convert into thermodynamically favored nanosheets through disassembling into monomers followed by reassembling process. Moreover, the two structurally different assemblies exhibit distinct photophysical performances. The intermediate Mn-TCPP aggregates show good light-induced singlet oxygen 1O2 generation for PDT while the thermodynamic favored stable Mn-TCPP aggregates exhibit good photothermal conversion ability as photothermal agents (PTAs). This study could facilitate controlling self-assembly pathway to fabricate complex MCPs with desirable applications.


2018 ◽  
Vol 54 (70) ◽  
pp. 9841-9844 ◽  
Author(s):  
Shuyan Yang ◽  
Defan Yao ◽  
Yanshu Wang ◽  
Weitao Yang ◽  
Bingbo Zhang ◽  
...  

A peptide-modified gold nanoparticle was developed for tumour-targeted therapy.


2021 ◽  
Author(s):  
Junyan Li ◽  
Qian Cheng ◽  
Ludan Yue ◽  
Cheng Gao ◽  
Jianwen Wei ◽  
...  

A macrophage-hitchhiking delivery system based on intracellular self-assembly of CuS nanoparticles was developed for reducing premature loss and specifically releasing nanomedicine in the tumor in response to the inflammatory microenvironment.


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