Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology

2022 ◽  
Author(s):  
Sam W. Henderson ◽  
Saeed Nourmohammadi ◽  
Sunita A. Ramesh ◽  
Andrea J. Yool
Keyword(s):  
Protein Structure ◽  
Cell Physiology ◽  
Ion Conductance

scholarly journals Investigations of Protein Structure and Function Using the Scientific Literature: An Assignment for an Undergraduate Cell Physiology Course

2003 ◽  
Vol 2 (4) ◽  
pp. 248-255 ◽  
Author(s):  
Amy B. Mulnix
Keyword(s):  
Protein Structure ◽  
Student Perceptions ◽  
Small Groups ◽  
Scientific Literature ◽  
Structure And Function ◽  
Cell Physiology ◽  
Protein Structure And Function ◽  
Undergraduate Biology ◽  
Research Article ◽  
And Function

Undergraduate biology curricula are being modified to model and teach the activities of scientists better. The assignment described here, one that investigates protein structure and function, was designed for use in a sophomore-level cell physiology course at Earlham College. Students work in small groups to read and present in poster format on the content of a single research article reporting on the structure and/or function of a protein. Goals of the assignment include highlighting the interdependence of protein structure and function; asking students to review, integrate, and apply previously acquired knowledge; and helping students see protein structure/function in a context larger than cell physiology. The assignment also is designed to build skills in reading scientific literature, oral and written communication, and collaboration among peers. Assessment of student perceptions of the assignment in two separate offerings indicates that the project successfully achieves these goals. Data specifically show that students relied heavily on their peers to understand their article. The assignment was also shown to require students to read articles more carefully than previously. In addition, the data suggest that the assignment could be modified and used successfully in other courses and at other institutions.

scholarly journals Molecular control of interfacial protein structure on graphene-based substrates steers cell fate

2020 ◽  
Author(s):  
Sachin Kumar ◽  
Sapun H. Parekh
Keyword(s):  
Stem Cell ◽  
Protein Structure ◽  
Physicochemical Properties ◽  
Cell Fate ◽  
Molecular Conformation ◽  
Cell Attachment ◽  
Cell Physiology ◽  
Molecular Control ◽  
Subtle Change ◽  
Multi Scale

AbstractThe use of graphene-based materials (GBMs) for tissue-engineering applications is growing exponentially due to the seemingly endless multi-functional and tunable physicochemical properties of graphene, which can be exploited to influence cellular behaviours. Despite many demonstrations wherein cell physiology can be modulated on GBMs, a clear mechanism connecting the different physicochemical properties of different GBMs to cell fate has remained elusive. In this work, we demonstrate how different GBMs can be used to cell fate in a multi-scale study – starting from serum protein (Fibronectin) adsorption to molecular scale morphology, structure and bioactivity, and finally ending with stem cell response. By changing the surface chemistry of graphene substrates with only heating, we show that molecular conformation and morphology of surface adsorbed fibronectin controls epitope presentation, integrin binding, and stem cell attachment. Moreover, this subtle change in protein structure is found to drive increased bone differentiation of cells, suggesting that physicochemical properties of graphene substrates exert cell control by influencing adsorbed protein structure.

Sequence Specific Dihedral Angle Distribution: Application in Protein Structure Prediction and Evaluation

1970 ◽  
Vol 19 (2) ◽  
pp. 217-226
Author(s):  
S. M. Minhaz Ud-Dean ◽  
Mahdi Muhammad Moosa
Keyword(s):  
Protein Structure ◽  
Dihedral Angle ◽  
Protein Structure Prediction ◽  
Structure Prediction ◽  
Protein Structures ◽  
Angle Distribution ◽  
Ramachandran Plot ◽  
Specific Data ◽  
Specific Distribution ◽  
Structure Evaluation

Protein structure prediction and evaluation is one of the major fields of computational biology. Estimation of dihedral angle can provide information about the acceptability of both theoretically predicted and experimentally determined structures. Here we report on the sequence specific dihedral angle distribution of high resolution protein structures available in PDB and have developed Sasichandran, a tool for sequence specific dihedral angle prediction and structure evaluation. This tool will allow evaluation of a protein structure in pdb format from the sequence specific distribution of Ramachandran angles. Additionally, it will allow retrieval of the most probable Ramachandran angles for a given sequence along with the sequence specific data. Key words: Torsion angle, φ-ψ distribution, sequence specific ramachandran plot, Ramasekharan, protein structure appraisal D.O.I. 10.3329/ptcb.v19i2.5439 Plant Tissue Cult. & Biotech. 19(2): 217-226, 2009 (December)

Protein structure prediction of human connexin 30 and its mutations in hearing system

2014 ◽  
Vol 3 (5) ◽  
Author(s):  
S. Reiisi ◽  
M. Hashemzade-chaleshtori ◽  
S. Reisi ◽  
H. Shahi ◽  
S. Parchami ◽  
...  
Keyword(s):  
Protein Structure ◽  
Protein Structure Prediction ◽  
Structure Prediction ◽  
Connexin 30 ◽  
Hearing System

LIPIDS AND CELL FUNCTION: a journey into the world of lipids to understand its function in cell physiology

2014 ◽  
Author(s):  
Anna Karenina Azevedo-Martins ◽  
Maria Fernanda Cury-Boaventura
Keyword(s):  
Cell Function ◽  
Cell Physiology ◽  
The World
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