Primary structures and conformations of stonefish toxin-like toxins from three species of rabbitfish, Siganus puellus, Siganus unimaculatus, and Siganus virgatus

2020 ◽  
Vol 86 (5) ◽  
pp. 889-901
Author(s):  
Aya Yoshinaga-Kiriake ◽  
Yuji Nagashima ◽  
Shoichiro Ishizaki ◽  
Kazuo Shiomi
Keyword(s):  
Primary Structures

scholarly journals Tackling Pristinamycin IIB Problems: Synthetic Studies toward Some Fluorinated Analogs

2020 ◽  
Vol 3 (1) ◽  
pp. 107
Author(s):  
Assia Chebieb ◽  
Chewki Ziani-Cherif
Keyword(s):  
Chemical Structure ◽  
Wittig Reaction ◽  
Antimicrobial Agents ◽  
Synthetic Approach ◽  
Solubility In Water ◽  
Fluorinated Analogs ◽  
Human Therapy ◽  
Primary Structures ◽  
Synthetic Studies

Streptogramins are potent antibiotics against numerous highly resistant pathogens and therefore are used in last-resort human therapy. These antibiotics are formed of both A- and B-group compounds named pristinamycins that differ in their basic primary structures. Although pristinamycin IIB is among the most interesting antibiotics in this family, it presents numerous problems related to its chemical structure, such as instability at most pH levels, weak solubility in water, and resistance by bacteria. As a response to the need for developing new antimicrobial agents, we have designed a new analog of pristinamycin IIB, based most importantly on the introduction of fluorine atoms. We conjectured indeed that the introduced modifications may solve the above-mentioned problems exhibited by pristinamycin IIB. Our multistep synthetic approach relies on few key reactions, namely a Wittig reaction, a Grubbs reaction, and dihydroxy, -difluoro API (Advanced Pharmaceutical Intermediate) synthesis

Primary structures of α-crystallin a chains of elephant, whale, hyrax and rhinoceros

1977 ◽  
Vol 491 (2) ◽  
pp. 573-580 ◽  
Author(s):  
Wilfried W. De Jong ◽  
Eugénie C. Nuy-Terwindt ◽  
Marlies Versteeg
Keyword(s):  
Primary Structures

Comparative study of the primary structures of sero-, lacto- and ovotransferrin glycans from different species

Biochimie ◽  
1988 ◽  
Vol 70 (11) ◽  
pp. 1459-1469 ◽  
Author(s):  
Geneviève Spik ◽  
Bernadette Coddeville ◽  
Jean Montreuil
Keyword(s):  
Comparative Study ◽  
Primary Structures
Sign in / Sign up

Export Citation Format

Share Document