Assessment of chitosan nanoparticles in improving the efficacy of nitazoxanide on cryptosporidiosis in immunosuppressed and immunocompetent murine models

2021 ◽  
Author(s):  
Howayda Said Fouad Moawad ◽  
Mohamed Hegab Abd El-Hady Hegab ◽  
Maha Saber Reda Badawey ◽  
Shaimaa Elsayed Ashoush ◽  
Shereen Mahmoud Ibrahim ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Murine Models

scholarly journals Molecular targeting of FATP4 transporter for oral delivery of therapeutic peptide

2020 ◽  
Vol 6 (14) ◽  
pp. eaba0145 ◽  
Author(s):  
Zhenhua Hu ◽  
Sara Nizzero ◽  
Shreya Goel ◽  
Louis E. Hinkle ◽  
Xiaoyan Wu ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Oral Absorption ◽  
Chitosan Nanoparticles ◽  
Gastric Fluid ◽  
Molecular Targeting ◽  
Murine Models ◽  
Long Chain Fatty Acid ◽  
Poor Patient Compliance ◽  
Therapeutic Peptides ◽  
High Bioavailability

Low oral bioavailability of peptide drugs has limited their application to parenteral administration, which suffers from poor patient compliance. Here, we show that molecular targeting of the FATP4 transporter is an effective approach to specifically transport long-chain fatty acid (LCFA)–conjugated peptides across the enterocytic membrane and, thus, enables oral delivery of drug peptides. We packaged LCFA-conjugated exendin-4 (LCFA-Ex4) into liposomes and coated with chitosan nanoparticles to form an orally deliverable Ex4 (OraEx4). OraEx4 protected LCFA-Ex4 from damage by the gastric fluid and released LCFA-Ex4 in the intestinal cavity, where LCFA-Ex4 was transported across the enterocyte membrane by the FAPT4 transporter. OraEx4 had a high bioavailability of 24.8% with respect to subcutaneous injection and exhibited a substantial hypoglycemic effect in murine models of diabetes mellitus. Thus, molecular targeting of the FATP4 transporter enhances oral absorption of therapeutic peptides and provides a platform for oral peptide drug development.

Extracellular ATP triggers and maintains airway inflammation in human and murine models of asthma by activating dendritic cells

Pneumologie ◽  
2008 ◽  
Vol 62 (S 2) ◽  
Author(s):  
M Idzko ◽  
D Ferrari ◽  
F Di Virgilio ◽  
S Sorichter ◽  
B Lambrecht ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Extracellular Atp ◽  
Murine Models

Optimization and Physicochemical Characterization of Chitosan and Chitosan Nanoparticles Extracted from the Crayfish Procambarus clarkii Wastes

2019 ◽  
Vol 38 (2) ◽  
pp. 385 ◽  
Author(s):  
Marwa M. El-Naggar ◽  
Wael S. I. Abou-Elmagd ◽  
Ashraf Suloma ◽  
Hamza A. El-Shabaka ◽  
Magdy T. Khalil ◽  
...  
Keyword(s):  
Procambarus Clarkii ◽  
Chitosan Nanoparticles ◽  
Physicochemical Characterization
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