Severity histologic score of acute pancreatitis in murine models: Preliminary results

2016 ◽  
Author(s):  
Rui Caetano Oliveira
Keyword(s):  
Acute Pancreatitis ◽  
Murine Models ◽  
Preliminary Results

Severity histologic score of acute pancreatitis in murine models: Preliminary results

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S19-S20
Author(s):  
Pedro Silva Vaz ◽  
Rui Oliveira ◽  
Ana Margarida Abrantes ◽  
Joăo Carlos Encarnaçăo ◽  
António Gouveia ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Murine Models ◽  
Preliminary Results

scholarly journals Pirfenidone increases IL10 and improves acute pancreatitis in multiple clinically relevant murine models

JCI Insight ◽  
2021 ◽  
Author(s):  
Ejas Palathingal Bava ◽  
John George ◽  
Mohammad Tarique ◽  
Srikanth Iyer ◽  
Preeti Sahay ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Murine Models

M1840 Detection and Identification of Bacterial DNA in Jejunal Liquid and Blood from Patients with Acute Pancreatitis As Evidence of Bacterial Traslocation: Preliminary Results

2008 ◽  
Vol 134 (4) ◽  
pp. A-430
Author(s):  
Enrique de-Madaria ◽  
María Dolores Picó ◽  
Juan Martínez ◽  
Rubén Francés ◽  
María Adelina Gimeno ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Bacterial Dna ◽  
Preliminary Results ◽  
Detection And Identification

Imipenem prophylaxis for predicted severe acute pancreatitis – Preliminary results of a randomized clinical trial

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S89 ◽  
Author(s):  
Goran Poropat ◽  
Vanja Giljaca ◽  
Vanja Licul ◽  
Goran Hauser ◽  
Sandra Milic ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Acute Pancreatitis ◽  
Randomized Clinical Trial ◽  
Severe Acute Pancreatitis ◽  
Preliminary Results

Vitamin A and Oxidative Stress in Murine Models of Acute Pancreatitis

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S27
Author(s):  
Pedro Silva Vaz ◽  
Inęs Baldeiras ◽  
Ana Margarida Abrantes ◽  
António Gouveia ◽  
Miguel Castelo-Branco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Pancreatitis ◽  
Vitamin A ◽  
Murine Models ◽  
And Oxidative Stress

Association of Systemic Inflammatory and Anti-inflammatory Responses with Adverse Outcomes in Acute Pancreatitis: Preliminary Results of an Ongoing Study

2017 ◽  
Vol 62 (12) ◽  
pp. 3468-3478 ◽  
Author(s):  
Deepesh Sharma ◽  
Aparna Jakkampudi ◽  
Ratnakar Reddy ◽  
Panyala Balakumar Reddy ◽  
Aasish Patil ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Inflammatory Responses ◽  
Adverse Outcomes ◽  
Ongoing Study ◽  
Preliminary Results ◽  
Anti Inflammatory

scholarly journals Murine Models of Acute Pancreatitis: A Critical Appraisal of Clinical Relevance

2019 ◽  
Vol 20 (11) ◽  
pp. 2794 ◽  
Author(s):  
Pedro Silva-Vaz ◽  
Ana Margarida Abrantes ◽  
Miguel Castelo-Branco ◽  
António Gouveia ◽  
Maria Filomena Botelho ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Targeted Therapies ◽  
Genetic Factors ◽  
Critical Appraisal ◽  
Severe Disease ◽  
Special Focus ◽  
High Morbidity ◽  
Murine Models ◽  
Distant Organ ◽  
New Biomarkers

Acute pancreatitis (AP) is a severe disease associated with high morbidity and mortality. Clinical studies can provide some data concerning the etiology, pathophysiology, and outcomes of this disease. However, the study of early events and new targeted therapies cannot be performed on humans due to ethical reasons. Experimental murine models can be used in the understanding of the pancreatic inflammation, because they are able to closely mimic the main features of human AP, namely their histologic glandular changes and distant organ failure. These models continue to be important research tools for the reproduction of the etiological, environmental, and genetic factors associated with the pathogenesis of this inflammatory pathology and the exploration of novel therapeutic options. This review provides an overview of several murine models of AP. Furthermore, special focus is made on the most frequently carried out models, the protocols used, and their advantages and limitations. Finally, examples are provided of the use of these models to improve knowledge of the mechanisms involved in the pathogenesis, identify new biomarkers of severity, and develop new targeted therapies.

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