The role of diet in the pathophysiology and management of irritable bowel syndrome

Enteroendocrine Cells ◽

Considerable Proportion ◽

World Population ◽

Western Countries ◽

Gut Endocrine Cells ◽

Irritable Bowel ◽

AbstractIrritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) disorder that reportedly affects 5% to 20% of the world population. The etiology of IBS is not completely understood, but diet appears to play an important role in its pathophysiology. Asian diets differ considerably from those in Western countries, which might explain differences in the prevalence, sex, and clinical presentation seen between patients with IBS in Asian and Western countries. Dietary regimes such as a low-fermentable oligo-, di-, monosaccharides, and polyols (FODMAP) diet and the modified National Institute for Health and Care Excellence (NICE) diet improve both symptoms and the quality of life in a considerable proportion of IBS patients. It has been speculated that diet is a prebiotic for the intestinal microbiota and favors the growth of certain bacteria. These bacteria ferment the dietary components, and the products of fermentation act upon intestinal stem cells to influence their differentiation into enteroendocrine cells. The resulting low density of enteroendocrine cells accompanied by low levels of certain hormones gives rise to intestinal dysmotility, visceral hypersensitivity, and abnormal secretion. This hypothesis is supported by the finding that changing to a low-FODMAP diet restores the density of GI cells to the levels in healthy subjects. These changes in gut endocrine cells caused by low-FODMAP diet are also accompanied by improvements in symptoms and the quality of life.

A Low-FODMAP Diet for Irritable Bowel Syndrome: Some Answers to the Doubts from a Long-Term Follow-Up

Nutrients ◽

10.3390/nu12082360 ◽

2020 ◽

Vol 12 (8) ◽

pp. 2360 ◽

Cited By ~ 2

Author(s):

Massimo Bellini ◽

Sara Tonarelli ◽

Federico Barracca ◽

Riccardo Morganti ◽

Andrea Pancetti ◽

...

Keyword(s):

Quality Of Life ◽

Nutritional Adequacy ◽

Related Quality ◽

Short And Long Term ◽

Irritable Bowel ◽

A low-FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) diet (LFD) is a possible therapy for irritable bowel syndrome (IBS). This study investigates the short- and long-term efficacy and nutritional adequacy of an LFD and the patients’ long-term acceptability. Patients’ adherence and ability to perceive the “trigger” foods were also evaluated. Seventy-three IBS patients were given an LFD (T0) and after 2 months (T1), 68 started the reintroduction phase. At the end of this period (T2), 59 were advised to go on an Adapted Low-FODMAP Diet (AdLFD) and 41 were evaluated again after a 6–24 month follow-up (T3). At each time, questionnaires and Biolectrical Impedance Vector Analysis (BIVA) were performed. The LFD was effective in controlling digestive symptoms both in the short- and long-term, and in improving quality of life, anxiety and depression, even if some problems regarding acceptability were reported and adherence decreased in the long term. The LFD improved the food-related quality of life without affecting nutritional adequacy. When data collected at T0 were compared with those collected at T2, the perception of trigger foods was quite different. Even if some problems of acceptability and adherence are reported, an LFD is nutritionally adequate and effective in improving IBS symptoms also in the long term.

821 A Low FODMAP Diet Improves Quality of Life, Reduces Activity Impairment, and Improves Sleep Quality in Patients With Irritable Bowel Syndrome and Diarrhea: Results From a U.S. Randomized, Controlled Trial

Gastroenterology ◽

10.1016/s0016-5085(16)30665-5 ◽

2016 ◽

Vol 150 (4) ◽

pp. S172 ◽

Cited By ~ 3

Author(s):

Shanti L. Eswaran ◽

William D. Chey ◽

Kenya Jackson ◽

Sivaram G. Pillai ◽

Samuel W. Chey ◽

...

Keyword(s):

Quality Of Life ◽

Randomized Controlled Trial ◽

Sleep Quality ◽

Controlled Trial ◽

Activity Impairment ◽

Randomized Controlled ◽

Irritable Bowel ◽

Effectiveness of Two Dietary Approaches on the Quality of Life and Gastrointestinal Symptoms of Individuals with Irritable Bowel Syndrome

Journal of Clinical Medicine ◽

10.3390/jcm9010125 ◽

2020 ◽

Vol 9 (1) ◽

pp. 125 ◽

Cited By ~ 1

Author(s):

Maria Margarida Guerreiro ◽

Zélia Santos ◽

Elisabete Carolino ◽

Julieta Correa ◽

Marilia Cravo ◽

...

Keyword(s):

Quality Of Life ◽

Clinical Trial ◽

Gastrointestinal Symptoms ◽

Standard Diet ◽

Before And After ◽

Irritable Bowel ◽

Fodmap Diet ◽

Third Moment

To evaluate the effectiveness of a low FODMAP (fermentable oligosaccharides, monosaccharaides, disaccharides and polyols) diet in the relief of symptoms and an improvement of the quality of life in individuals with irritable bowel syndrome in comparison to a standard diet according to the British Dietetic Association’s guidelines. A non-randomized clinical trial of adult patients with IBS was compared two diet interventions. An assessment of symptoms, quality of life, and nutritional status was performed before and after the four-week mark of intervention. Individuals from the Low FODMAP Diet (LFD) group were evaluated on a third moment, after the controlled reintroduction of FODMAPs. A total of 70 individuals were divided in two groups: Low FODMAP Diet (LFD; n = 47) and Standard Diet (SD; n = 23). 57 individuals completed the four-week intervention (LFD; n = 39; SD; n = 18). At the completion of four weeks, the symptoms improved in both groups (LFD: p < 0.01; DC: p < 0.05) but LFD led to a higher relief (p < 0.05), primarily with respect to abdominal pain and diarrhoea. Quality of life improved significantly in both groups, with no significant differences between SD vs LFD (p > 0.05). In the LFD group, the relief of symptoms observed at the four-week mark remained constant after reintroduction of FODMAPs. Both interventions seem to be effective for the relief of symptoms and quality of life, however LFD had higher effectiveness in the former. The results with LFD suggest it can be a preferred approach in individuals with diarrhoeal profile.

Effectiveness of two dietary approaches in improving symptoms and quality of life of individuals with irritable bowel syndrome: Low fodmap diet versus standard diet

Clinical Nutrition ◽

10.1016/j.clnu.2018.06.1680 ◽

2018 ◽

Vol 37 ◽

pp. S187-S188 ◽

Cited By ~ 1

Author(s):

M.M. Guerreiro ◽

C.S. Guerreiro ◽

M. Cravo ◽

Z. Santos ◽

C. Chagas ◽

...

Keyword(s):

Quality Of Life ◽

Standard Diet ◽

Diet Versus ◽

Irritable Bowel ◽

Bacillus spp. Spores—A Promising Treatment Option for Patients with Irritable Bowel Syndrome

Nutrients ◽

10.3390/nu11091968 ◽

2019 ◽

Vol 11 (9) ◽

pp. 1968 ◽

Cited By ~ 5

Author(s):

Catinean ◽

Neag ◽

Nita ◽

Buzea ◽

Buzoianu

Keyword(s):

Quality Of Life ◽

Treatment Regimens ◽

Rectal Volume ◽

Severity Scores ◽

Gastrointestinal Problems ◽

Bacillus Spp ◽

Irritable Bowel ◽

Dysbiosis is a condition that can cause various clinical disorders, from gastrointestinal problems to allergies or even cancer. Resetting the microbiota using antibiotics and/or probiotics could be a possible therapy for many diseases. The aim of this study was to evaluate the effects of three treatment regimens in patients with irritable bowel syndrome (IBS). The regimens were short-term rifaximin treatment (10 days) followed by either a nutraceutical agent (G1) or a low- Fermentable, Oligo-, Di-, Monosaccharide and Polyol (FODMAP) diet (24 days) (G3) or treatment with MegaSporeBiotic a mixture of spores of five Bacillus spp. for medium-term (34 days) (G2). Ninety patients with IBS without constipation were enrolled and divided into three groups (G1, G2, G3). Patients in G1 and G3 were evaluated over four visits (baseline/first day (V1), 10 days (V2), 34 days (V3), 60 days (V4)), and, those in G2 over three visits (V1, V3, V4). Severity score, quality of life, and parameters from the rectal volume sensation test were determined. The results demonstrated that patients treated with MegaSporeBiotic, compared with those treated with rifaximin followed by nutraceutical or low-FODMAP diet, had similar severity scores and rectal volume sensation test results for all parameters tested and statistically significant improvement in measurements of quality of life.

The Effects of Low FODMAP Diet on the Quality of Life and Gastrointestinal Symptoms in Children with Irritable Bowel Syndrome. A Pilot Study

Journal of Dr Behcet Uz Children s Hospital ◽

10.5222/buchd.2021.64325 ◽

2021 ◽

Author(s):

Ecem İpek Altınok ◽

Çiğdem Ömür Ecevit ◽

Zeynep Akişin ◽

Aslı Ata Teneler ◽

Özlem Bağ

Keyword(s):

Quality Of Life ◽

Gastrointestinal Symptoms ◽

Well Being ◽

Common Symptom ◽

Time Of Application ◽

Before And After ◽

Irritable Bowel ◽

Objective: Irritable bowel syndrome is a disease that negatively affects life. Recently, diet therapies have been emphasized. Our study, the aim was to investigate the effect of low FODMAP (fermented oligo-, di-, monosaccharide and polyols) diet on the frequency of gastrointestinal symptoms and the effects on quality of life in patients with IBS. Method: 18 children aged between 7-18 years, who were diagnosed with IBS, followed by University of Health Sciences Izmir Dr. Behçet Uz Children’s Diseases and Surgery Training and Research Hospital the Child Gastroenterology, Hepatology and Nutrition Clinic were included in the study. The appropriate KINDL scale was applied at the time of application and 2 weeks after the end of the low FODMAP diet. GIS symptoms of the week 0 and 6 KINDL results were compared. KINDL scale was applied to the families before and after dieting and the results were compared. Results: The study was completed with 10 patients. The most common symptom was abdominal pain and it was present in all patients. All symptoms were found to decrease after diet but it was not significant. There was a significant increases in emotional well-being, family divisions and total KINDL results at the 6th week of diet in the children In parent KINDL scales, the results were not considered significant. Conclusion: Despite there was a decrease in GIS related complaints and increase in quality of life in IBS patients who underwent low FODMAP diet, it has been found appropriate to continue the study with larger patient groups for longer follow-up periods.