scholarly journals The Link Between Androgen Receptor Splice Variants and Castration-Resistant Prostate Cancer

2014 ◽  
Vol 5 (4) ◽  
pp. 207-217 ◽  
Author(s):  
Cynthia C. T. Sprenger ◽  
Stephen R. Plymate
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Splice Variants ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Androgen Receptor Splice Variants

scholarly journals Data of relative mRNA and protein abundances of androgen receptor splice variants in castration-resistant prostate cancer

Data in Brief ◽  
2021 ◽  
Vol 34 ◽  
pp. 106774
Author(s):  
Tianfang Ma ◽  
Nathan Ungerleider ◽  
Derek Y. Zhang ◽  
Eva Corey ◽  
Erik K. Flemington ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Splice Variants ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Androgen Receptor Splice Variants

scholarly journals Emerging data on androgen receptor splice variants in prostate cancer

2016 ◽  
Vol 23 (12) ◽  
pp. T199-T210 ◽  
Author(s):  
Subing Cao ◽  
Yang Zhan ◽  
Yan Dong
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Splice Variants ◽  
Deep Understanding ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Splicing Variants ◽  
Current Therapies ◽  
Alternatively Spliced ◽  
Androgen Receptor Splice Variants

Androgen receptor splice variants are alternatively spliced variants of androgen receptor, which are C-terminally truncated and lack the canonical ligand-binding domain. Accumulating evidence has indicated a significant role of androgen receptor splice variants in mediating resistance of castration-resistant prostate cancer to current therapies and in predicting therapeutic responses. As such, there is an urgent need to target androgen receptor splicing variants for more effective treatment of castration-resistant prostate cancer. Identification of precise and critical targeting points to deactivate androgen receptor splicing variants relies on a deep understanding of how they are generated and the mechanisms of their action. In this review, we will focus on the emerging data on their generation, clinical significance and mechanisms of action as well as the therapeutic influence of these findings.

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