Multi-label feature selection via feature manifold learning and sparsity regularization

2017 ◽  
Vol 9 (8) ◽  
pp. 1321-1334 ◽  
Author(s):  
Zhiling Cai ◽  
William Zhu
Keyword(s):  
Feature Selection ◽  
Manifold Learning ◽  
Sparsity Regularization

scholarly journals Prediction of hot spots in protein–DNA binding interfaces based on supervised isometric feature mapping and extreme gradient boosting

2020 ◽  
Vol 21 (S13) ◽  
Author(s):  
Ke Li ◽  
Sijia Zhang ◽  
Di Yan ◽  
Yannan Bin ◽  
Junfeng Xia
Keyword(s):  
Feature Selection ◽  
Manifold Learning ◽  
Hot Spots ◽  
Large Scale ◽  
Computational Method ◽  
Gradient Boosting ◽  
Feature Mapping ◽  
Accessible Information ◽  
Extreme Gradient Boosting ◽  
Isometric Feature Mapping

Abstract Background Identification of hot spots in protein-DNA interfaces provides crucial information for the research on protein-DNA interaction and drug design. As experimental methods for determining hot spots are time-consuming, labor-intensive and expensive, there is a need for developing reliable computational method to predict hot spots on a large scale. Results Here, we proposed a new method named sxPDH based on supervised isometric feature mapping (S-ISOMAP) and extreme gradient boosting (XGBoost) to predict hot spots in protein-DNA complexes. We obtained 114 features from a combination of the protein sequence, structure, network and solvent accessible information, and systematically assessed various feature selection methods and feature dimensionality reduction methods based on manifold learning. The results show that the S-ISOMAP method is superior to other feature selection or manifold learning methods. XGBoost was then used to develop hot spots prediction model sxPDH based on the three dimensionality-reduced features obtained from S-ISOMAP. Conclusion Our method sxPDH boosts prediction performance using S-ISOMAP and XGBoost. The AUC of the model is 0.773, and the F1 score is 0.713. Experimental results on benchmark dataset indicate that sxPDH can achieve generally better performance in predicting hot spots compared to the state-of-the-art methods.

scholarly journals Multi-label feature selection based on logistic regression and manifold learning

2021 ◽  
Author(s):  
Yao Zhang ◽  
Yingcang Ma ◽  
Xiaofei Yang
Keyword(s):  
Logistic Regression ◽  
Feature Selection ◽  
Manifold Learning ◽  
High Dimensional ◽  
Data Sets ◽  
Efficiency Improvement ◽  
Effective Technique ◽  
Sparse Regularization ◽  
Label Information ◽  
Feature Weight

Like traditional single label learning, multi-label learning is also faced with the problem of dimensional disaster.Feature selection is an effective technique for dimensionality reduction and learning efficiency improvement of high-dimensional data. In this paper, Logistic regression, manifold learning and sparse regularization were combined to construct a joint framework for multi-label feature selection (LMFS). Firstly, the sparsity of the eigenweight matrix is constrained by the $L_{2,1}$-norm. Secondly, the feature manifold and label manifold can constrain the feature weight matrix to make it fit the data information and label information better. An iterative updating algorithm is designed and the convergence of the algorithm is proved.Finally, the LMFS algorithm is compared with DRMFS, SCLS and other algorithms on eight classical multi-label data sets. The experimental results show the effectiveness of LMFS algorithm.

Manifold learning with structured subspace for multi-label feature selection

2021 ◽  
pp. 108169
Author(s):  
Yuling Fan ◽  
Jinghua Liu ◽  
Peizhong Liu ◽  
Yongzhao Du ◽  
Weiyao Lan ◽  
...  
Keyword(s):  
Feature Selection ◽  
Manifold Learning
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