Mesenchymal stem cell-derived exosome mir-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4

2022 ◽  
Author(s):  
Shuyao Yu ◽  
Yuhui Zhou ◽  
Ligang Niu ◽  
Yan Qiao ◽  
Yu Yan
Stem Cells ◽  
2011 ◽  
Vol 29 (7) ◽  
pp. 1149-1157 ◽  
Author(s):  
Roisin M. Dwyer ◽  
James Ryan ◽  
Ronan J. Havelin ◽  
John C. Morris ◽  
Brian W. Miller ◽  
...  

2018 ◽  
Vol 9 ◽  
pp. 204173141881009 ◽  
Author(s):  
Jake Casson ◽  
Owen G Davies ◽  
Carol-Anne Smith ◽  
Matthew J Dalby ◽  
Catherine C Berry

Disseminated breast cancer cells have the capacity to metastasise to the bone marrow and reside in a dormant state within the mesenchymal stem cell niche. Research has focussed on paracrine signalling factors, such as soluble proteins, within the microenvironment. However, it is now clear extracellular vesicles secreted by resident mesenchymal stem cells into this microenvironment also play a key role in the initiation of dormancy. Dormancy encourages reduced cell proliferation and migration, while upregulating cell adhesion, thus retaining the cancer cells within the bone marrow microenvironment. Here, MCF7 breast cancer cells were treated with mesenchymal stem cell–derived extracellular vesicles, resulting in reduced migration in two-dimensional and three-dimensional culture, with reduced cell proliferation and enhanced adhesion, collectively supporting cancer cell dormancy.


2016 ◽  
Vol 76 (19) ◽  
pp. 5832-5844 ◽  
Author(s):  
Sarah A. Bliss ◽  
Garima Sinha ◽  
Oleta A. Sandiford ◽  
Lisa M. Williams ◽  
Daniel J. Engelberth ◽  
...  

2013 ◽  
Vol 22 (10) ◽  
pp. 1869-1882 ◽  
Author(s):  
Shun-Pei Hung ◽  
Muh-Hwa Yang ◽  
Kuo-Fung Tseng ◽  
Oscar K. Lee

2009 ◽  
Vol 124 (2) ◽  
pp. 326-332 ◽  
Author(s):  
Alan P. Molloy ◽  
Fiachra T. Martin ◽  
Roisin M. Dwyer ◽  
Tomas P. Griffin ◽  
Mary Murphy ◽  
...  

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