Abstract 505: Hypoxia inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.

2013 ◽  
Author(s):  
Pallavi Chaturvedi ◽  
Daniele Gilkes ◽  
Gregg Semenza
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Hypoxia Inducible Factor ◽  
Bidirectional Signaling

scholarly journals Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis

2013 ◽  
Vol 123 (3) ◽  
pp. 1402-1402 ◽  
Author(s):  
Pallavi Chaturvedi ◽  
Daniele M. Gilkes ◽  
Carmen Chak Lui Wong ◽  
Kshitiz Kshitiz ◽  
Weibo Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Hypoxia Inducible Factor ◽  
Bidirectional Signaling

scholarly journals Mesenchymal Stem Cell-Mediated Delivery of the Sodium Iodide Symporter Supports Radionuclide Imaging and Treatment of Breast Cancer

Stem Cells ◽  
2011 ◽  
Vol 29 (7) ◽  
pp. 1149-1157 ◽  
Author(s):  
Roisin M. Dwyer ◽  
James Ryan ◽  
Ronan J. Havelin ◽  
John C. Morris ◽  
Brian W. Miller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Radionuclide Imaging ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter

scholarly journals Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy

2018 ◽  
Vol 9 ◽  
pp. 204173141881009 ◽  
Author(s):  
Jake Casson ◽  
Owen G Davies ◽  
Carol-Anne Smith ◽  
Matthew J Dalby ◽  
Catherine C Berry
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Breast Cancer Cells ◽  
Cell Dormancy

Disseminated breast cancer cells have the capacity to metastasise to the bone marrow and reside in a dormant state within the mesenchymal stem cell niche. Research has focussed on paracrine signalling factors, such as soluble proteins, within the microenvironment. However, it is now clear extracellular vesicles secreted by resident mesenchymal stem cells into this microenvironment also play a key role in the initiation of dormancy. Dormancy encourages reduced cell proliferation and migration, while upregulating cell adhesion, thus retaining the cancer cells within the bone marrow microenvironment. Here, MCF7 breast cancer cells were treated with mesenchymal stem cell–derived extracellular vesicles, resulting in reduced migration in two-dimensional and three-dimensional culture, with reduced cell proliferation and enhanced adhesion, collectively supporting cancer cell dormancy.

scholarly journals Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow

2016 ◽  
Vol 76 (19) ◽  
pp. 5832-5844 ◽  
Author(s):  
Sarah A. Bliss ◽  
Garima Sinha ◽  
Oleta A. Sandiford ◽  
Lisa M. Williams ◽  
Daniel J. Engelberth ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Early Breast Cancer ◽  
Cancer Dormancy
Sign in / Sign up

Export Citation Format

Share Document