Long non-coding RNA NEAT1 decreases the chemosensitivity of gastric cancer cells via regulating P-glycoprotein expression

2017 ◽  
Vol 13 (3) ◽  
pp. 317-325 ◽  
Author(s):  
Jian Wang ◽  
Qiong Niu ◽  
Ning Shi ◽  
Chengxia Liu ◽  
Haifeng Lian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
P Glycoprotein ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells

FEBS Journal ◽  
2012 ◽  
Vol 279 (17) ◽  
pp. 3159-3165 ◽  
Author(s):  
Feng Yang ◽  
Jianwei Bi ◽  
Xuchao Xue ◽  
Luming Zheng ◽  
Kangkang Zhi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long Non-Coding RNA HAND2-AS1 Inhibits Growth and Migration of Gastric Cancer Cells Through Regulating the miR-590-3p/KCNT2 Axis [Retraction]

2021 ◽  
Vol Volume 14 ◽  
pp. 4997-4998
Author(s):  
Lan Yu ◽  
Hui Li ◽  
Zhiying Li ◽  
Jianchao Jia ◽  
Zhouying Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Non Coding Rna ◽  
And Migration ◽  
Long Non Coding Rna

LncRNA-SNHG7 interferes with miR-34a to de-sensitize gastric cancer cells to cisplatin

2020 ◽  
pp. 1-11
Author(s):  
Li-Juan Pei ◽  
Peng-Jun Sun ◽  
Kui Ma ◽  
Yan-Yan Guo ◽  
Ling-Yan Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Luciferase Assay ◽  
Gastric Cancer Cells ◽  
Non Coding Rna ◽  
Important Regulator ◽  
Cancer Tissues ◽  
Long Non Coding Rna ◽  
Resistant Cells

Gastric cancer (GC) remains poor prognosis and survival issues due to the resistance of chemotherapies, such as cisplatin. The long non-coding RNA small nucleolar RNA host gene 7 (lncRNA-SNHG7) is known as an oncogenic molecule in diverse cancers. Here, we demonstrate that SNHG7 was significantly upregulated in gastric cancer and positively correlated with cisplatin resistance of gastric cancer cells that SNHG7 was significantly upregulated in cisplatin resistant cells. Silencing SNHG7 dramatically sensitized cisplatin resistant cells. In contrast, a negative correlation between lncRNA-SNHG7 and miR-34a was found that miR-34a was downregulated in gastric cancer patient tissues and significantly sensitized cisplatin resistant gastric cancer cells. Intriguingly, bioinformatical analysis indicated miR-34a has putative biding site for SNHG7 and such negative association between SNHG7 and miR-34a was verified in gastric cancer tissues. The cisplatin resistant cells displayed increased glycolysis rate and SNHG7 promoted cellular glycolysis rate of gastric cancer cells. Luciferase assay illustrated LDHA, a glycolysis enzyme, was the direct target of miR-34a. Importantly, inhibiting SNHG7 successfully suppressed LDHA expressions and sensitized cisplatin resistant cells and such inhibitory effects could be recovered by further anti-miR-34a. These findings suggest an important regulator mechanism for the SNHG7-mediated cisplatin resistance via miR-34a/LDHA-glycolysis axis.

scholarly journals Long Non-Coding RNA HAND2-AS1 Inhibits Growth and Migration of Gastric Cancer Cells Through Regulating the miR-590-3p/KCNT2 Axis

2020 ◽  
Vol Volume 13 ◽  
pp. 3187-3196 ◽  
Author(s):  
Lan Yu ◽  
Hui Li ◽  
Zhiying Li ◽  
Jianchao Jia ◽  
Zhouying Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Non Coding Rna ◽  
And Migration ◽  
Long Non Coding Rna
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