Single nucleotide polymorphisms (SNPs) of hOGG1 and XRCC1 DNA repair genes and the risk of ovarian cancer in Polish women

Tumor Biology ◽  
2015 ◽  
Vol 36 (12) ◽  
pp. 9457-9463 ◽  
Author(s):  
Magdalena M. Michalska ◽  
Dariusz Samulak ◽  
Hanna Romanowicz ◽  
Jan Bieńkiewicz ◽  
Maciej Sobkowski ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Dna Repair ◽  
Single Nucleotide Polymorphisms ◽  
Dna Repair Genes ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Repair Genes

scholarly journals Single Nucleotide Polymorphisms of RecQ1, RAD54L, and ATM Genes Are Associated With Reduced Survival of Pancreatic Cancer

2006 ◽  
Vol 24 (11) ◽  
pp. 1720-1728 ◽  
Author(s):  
Donghui Li ◽  
Marsha Frazier ◽  
Douglas B. Evans ◽  
Kenneth R. Hess ◽  
Christopher H. Crane ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Dna Repair ◽  
Single Nucleotide Polymorphisms ◽  
Cox Regression ◽  
Dna Repair Genes ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Clinical Prognosis ◽  
Repair Genes

Purpose Our goal was to determine whether single nucleotide polymorphisms (SNPs) in DNA repair genes influence the clinical outcome of pancreatic cancer. Patients and Methods We evaluated 13 SNPs of eight DNA damage response and repair genes in 92 patients with potentially resectable pancreatic adenocarcinoma. All patients were treated with neoadjuvant concurrent gemcitabine and radiotherapy with or without a component of induction gemcitabine/cisplatin at The University of Texas M.D. Anderson Cancer Center (Houston, TX) from February 1999 to August 2004 and observed through August 2005. Response to the pretreatment was assessed by evaluating time to tumor progression and overall survival. Kaplan-Meier plot, log-rank test, and Cox regression were used to compare survival of patients according to genotype. Results The RecQ1 A159C, RAD54L C157T, XRCC1 R194W, and ATM T77C genotypes had a significant effect on the overall survival with log-rank P values of .001, .004, .001, and .02, respectively. A strong combined effect of the four genotypes was observed. Patients with none of the adverse genotypes had a mean survival time of 62.1 months, and those with one, two, or three or more at-risk alleles had median survival times of 27.5, 14.4, and 9.9 months, respectively (log-rank P < .001). There is a significant interaction between the RecQ1 gene and other genotypes. All four genes except XRCC1 remained as independent predictors of survival in multivariate Cox regression models adjusted for other clinical predictors. Conclusion These observations support the hypothesis that polymorphic variants of DNA repair genes affect clinical prognosis of patients with pancreatic cancer.

scholarly journals Yeast-based assays for characterization of the functional effects of single nucleotide polymorphisms in human DNA repair genes

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193823
Author(s):  
Changshin Kim ◽  
Jinmo Yang ◽  
Su-Hyun Jeong ◽  
Hayoung Kim ◽  
Geun-hee Park ◽  
...  
Keyword(s):  
Dna Repair ◽  
Single Nucleotide Polymorphisms ◽  
Dna Repair Genes ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Human Dna ◽  
Repair Genes

scholarly journals Single nucleotide polymorphisms (SNPs) of ERCC2, hOGG1, and XRCC1 DNA repair genes and the risk of triple-negative breast cancer in Polish women

Tumor Biology ◽  
2014 ◽  
Vol 35 (4) ◽  
pp. 3495-3502 ◽  
Author(s):  
Beata Smolarz ◽  
Marianna Makowska ◽  
Dariusz Samulak ◽  
Magdalena M. Michalska ◽  
Ewa Mojs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Single Nucleotide Polymorphisms ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Dna Repair Genes ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Repair Genes

scholarly journals Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study

2011 ◽  
Vol 32 (8) ◽  
pp. 1223-1230 ◽  
Author(s):  
M. R. Roberts ◽  
P. G. Shields ◽  
C. B. Ambrosone ◽  
J. Nie ◽  
C. Marian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Single Nucleotide Polymorphisms ◽  
Dna Repair Genes ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Repair Genes ◽  
The Web
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