Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members

The idea of heritability may have consequences for individuals’ sense of self by connecting identity to the actions of others who happen to share genetic ties. Across seven experimental studies (total N=2,628), recalling morally bad or good actions by family members influenced individuals’ moral self among those who endorse a lay belief that moral character is genetically heritable, but not among those who did not endorse this belief (Study 1-5). In contrast, recalling actions by unrelated individuals had no effect, regardless of lay beliefs (Study 2, 5), the endorsement of other relevant lay beliefs did not moderate the effect of parent’s actions on self-judgments (Study 3). Individuals who endorsed heritability beliefs also chose less helpful responses to hypothetical helping scenarios if they had recalled unhelpful (vs. helpful) acts by a genetically-related family member (Study 5). Taken together, these studies suggest that lay beliefs in the role of genetics are important for self-perceptions.

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Crianças com incontinência urinária: impacto na convivência dos familiares

Revista de Enfermagem UFPE on line ◽

10.5205/1981-8963-v12i7a234837p2061-2073-2018 ◽

2018 ◽

Vol 12 (7) ◽

pp. 2061

Author(s):

Ivanda Araújo Matias Issa de Oliveira ◽

Cristiane Feitosa Salviano ◽

Gisele Martins

Keyword(s):

Urinary Incontinence ◽

Family Members ◽

Health Science ◽

Related Family ◽

Calidad De Vida ◽

Family Routine ◽

As Stress ◽

The Impact

RESUMOObjetivo: Identificar fatores que impactam na convivência dos familiares de crianças com incontinência urinária. Método: Estudo bibliográfico, descritivo, tipo revisão integrativa, com busca de artigos no mês de setembro de 2017, nas bases de dados LILACS, BDENF, MEDLINE e CINAHL. Considerou-se o recorte temporal de janeiro de 2012 a dezembro de 2017, utilizando os Descritores em Ciência da Saúde (DeCS) controlados e não controlados no idioma inglês e português. Resultados: Foram incluídos 11 artigos, publicados entre 2012 e 2016, destacando-se três categorias: 1) O nível educacional dos pais como um fator de impacto; 2) O impacto na qualidade de vida dos familiares; e 3) As mudanças que impactam no cotidiano familiar. Conclusões: A incontinência urinária afeta a rotina familiar e pode provocar transtornos psicológicos como estresse, ansiedade e depressão nas crianças e em seus familiares. Houve escassez de produções que relacionassem a percepção do familiar ante a incontinência urinária diurna e fecal com o nível escolar dos pais. Evidencia-se o papel do enfermeiro que atua em uropediatria sobre a importância da compreensão da convivência familiar, a fim de contribuir com o delinear de orientações voltadas para a educação e compreensão das experiências vividas pelos cuidadores. Descritores: Incontinência Urinária; Família; Cuidadores; Crianças; Enurese; Incontinência Urinária por Estresse.ABSTRACTObjective: To identify factors that have an impact on the coexistence of family members of children with urinary incontinence. Method: Bibliographic, descriptive, integrative review type study with search of articles in September 2017, in LILACS, BDENF, MEDLIN, and CINAHL databases. We considered the temporal cut from January 2012 to December 2017, using controlled and uncontrolled Health Science Descriptors (DeCS) in English and Portuguese. Results: We included 11 articles, published between 2012 and 2016, highlighting three categories: 1) The educational level of parents as an impact factor; 2) The impact on the quality of life of family members; and 3) The changes that impact on daily family life. Conclusions: Urinary incontinence affects the family routine and can cause psychological disorders, such as stress, anxiety, and depression in children and their family members. There was a shortage of productions that related family members' perceptions of diurnal urinary incontinence and fecal incontinence to the parents' education level. The role of nurses working in pediatric urology was evident with respect to the importance of understanding family coexistence in order to contribute to the delineation of guidelines aimed at the education and understanding of caregivers' experiences. Descriptors: Urinary Incontinence; Family; Caregivers; Children; Enuresis; Urinary Incontinence Due to Stress.RESUMENObjetivo: Identificar factores que impactan en la convivencia de los familiares de niños con incontinencia urinaria. Método: Estudio bibliográfico, descriptivo, tipo revisión integradora, con búsqueda de artículos en el mes de septiembre de 2017, en las bases de datos LILACS, BDENF, MEDLINE y CINAHL. Fue considerado el recorte temporal de enero de 2012 a diciembre de 2017, utilizando los Descriptores en Ciencias de la Salud (DeCS) controlados y no controlados en idioma Inglés y portugués. Resultados: Se incluyeron 11 artículos publicados entre 2012 y 2016, destacándose tres categorías: 1) El nivel educativo de los padres como un factor de impacto; 2) El impacto en la calidad de vida de los familiares; y 3) Los cambios que impactan en el cotidiano familiar. Conclusiones: La incontinencia urinaria afecta la rutina familiar y puede provocar trastornos psicológicos como estrés, ansiedad y depresión en los niños y en sus familiares. Hubo escasez de producciones que relacionaran la percepción de los familiares ante la incontinencia urinaria diurna e incontinencia fecal con el nivel escolar de los padres. Se evidencia el papel del enfermero que actúa en urología pediátrica con respecto a la importancia de la comprensión de la convivencia familiar, a fin de contribuir con el delinear de orientaciones sobre la educación y comprensión de las experiencias vividas por los cuidadores. Descriptores: Incontinencia Urinaria; Familia; Cuidadores; Niños; Enuresis; Incontinencia Urinaria por Estrés.

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Validation of Melampsora larici-populina reference genes for in planta RT-quantitative PCR expression profiling during time-course infection of poplar leaves

Physiological and Molecular Plant Pathology ◽

10.1016/j.pmpp.2010.10.003 ◽

2011 ◽

Vol 75 (3) ◽

pp. 106-112 ◽

Cited By ~ 29

Author(s):

Stéphane Hacquard ◽

Claire Veneault-Fourrey ◽

Christine Delaruelle ◽

Pascal Frey ◽

Francis Martin ◽

...

Keyword(s):

Quantitative Pcr ◽

Expression Profiling ◽

Reference Genes ◽

Time Course ◽

In Planta ◽

Poplar Leaves

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Combined metabolite and tissue expression profiling of TOP2A and EZH2 predicts biochemical recurrence in prostate cancer radiotherapy patients

European Urology Supplements ◽

10.1016/s1569-9056(19)33319-6 ◽

2019 ◽

Vol 18 (8) ◽

pp. e3070-e3071

Author(s):

A.F. Hansen ◽

T.S. Høiem ◽

K.M. Selnæs ◽

A.M. Bofin ◽

H. Bertilsson ◽

...

Keyword(s):

Prostate Cancer ◽

Expression Profiling ◽

Biochemical Recurrence ◽

Tissue Expression ◽

Cancer Radiotherapy ◽

Prostate Cancer Radiotherapy

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Crystal structure of the M5muscarinic acetylcholine receptor

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1914446116 ◽

2019 ◽

Vol 116 (51) ◽

pp. 26001-26007 ◽

Cited By ~ 5

Author(s):

Ziva Vuckovic ◽

Patrick R. Gentry ◽

Alice E. Berizzi ◽

Kunio Hirata ◽

Swapna Varghese ◽

...

Keyword(s):

Crystal Structure ◽

Acetylcholine Receptor ◽

Rational Design ◽

Structural Information ◽

Family Members ◽

Muscarinic Acetylcholine Receptor ◽

Receptor Subtype ◽

Ligand Interaction ◽

Related Family ◽

Allosteric Sites

The human M5muscarinic acetylcholine receptor (mAChR) has recently emerged as an exciting therapeutic target for treating a range of disorders, including drug addiction. However, a lack of structural information for this receptor subtype has limited further drug development and validation. Here we report a high-resolution crystal structure of the human M5mAChR bound to the clinically used inverse agonist, tiotropium. This structure allowed for a comparison across all 5 mAChR family members that revealed important differences in both orthosteric and allosteric sites that could inform the rational design of selective ligands. These structural studies, together with chimeric swaps between the extracellular regions of the M2and M5mAChRs, provided structural insight into kinetic selectivity, where ligands show differential residency times between related family members. Collectively, our study provides important insights into the nature of orthosteric and allosteric ligand interaction across the mAChR family that could be exploited for the design of selective drugs.

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Therapeutic inhibition of BCL-2 and related family members

Expert Opinion on Investigational Drugs ◽

10.1080/13543784.2017.1290078 ◽

2017 ◽

Vol 26 (3) ◽

pp. 293-301 ◽

Cited By ~ 14

Author(s):

Michelle A. Levy ◽

David F. Claxton

Keyword(s):

Family Members ◽

Related Family

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Molecular genetics of chromosome translocations involving EWS and related family members

Physiological Genomics ◽

10.1152/physiolgenomics.1999.1.3.127 ◽

1999 ◽

Vol 1 (3) ◽

pp. 127-138 ◽

Cited By ~ 45

Author(s):

JUNGHO KIM ◽

JERRY PELLETIER

Keyword(s):

Transcription Factors ◽

Dna Binding ◽

Molecular Genetics ◽

Family Members ◽

Binding Domain ◽

Dna Binding Domain ◽

Chromosome Translocations ◽

Amino Terminal ◽

Terminal Domain ◽

Related Family

Kim, Jungho, and Jerry Pelletier. Molecular genetics of chromosome translocations involving EWS and related family members. Physiol. Genomics 1: 127–138, 1999.—Many types of sarcomas are characterized by specific chromosomal translocations that appear to result in the production of novel, tumor-specific chimeric transcription factors. Many of these show striking similarities: the emerging picture is that the amino-terminal domain of the fusion product is donated by the Ewing's sarcoma gene ( EWS) or a related member from the same gene family, whereas the carboxy-terminal domain often consists of a DNA-binding domain derived from one of a number of transcription factors. Given the observation that the different translocation partners of the EWS protooncogene are associated with distinct types of sarcomas, the functional consequence of fusing EWS (or a related family member) to a different DNA-binding domain can only be understood in the context of functional studies that define the specificity of action of the different fusion products. An understanding of the molecular structure and function of these translocations provides new methods for diagnosis and novel targets for therapeutics.

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