scholarly journals Three-Year Glycaemic Control and Management in Patients with Type 2 Diabetes Initiating Second-Line Treatment in Japan: A Prospective Observational Study, J-DISCOVER

2021 ◽  
Author(s):  
Mitsuyoshi Takahara ◽  
Tomoya Mita ◽  
Naoto Katakami ◽  
Fumitaka Wada ◽  
Naru Morita ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Line Treatment ◽  
Second Line ◽  
Control And Management

scholarly journals Different patterns of second-line treatment in type 2 diabetes after metformin monotherapy in Denmark, Finland, Norway and Sweden (D360 Nordic): A multinational observational study

2018 ◽  
Vol 1 (4) ◽  
pp. e00036 ◽  
Author(s):  
Frederik Persson ◽  
Johan Bodegard ◽  
Jorma T. Lahtela ◽  
Thomas Nyström ◽  
Marit E. Jørgensen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Observational Study ◽  
Line Treatment ◽  
Second Line ◽  
Metformin Monotherapy

scholarly journals The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Takahisa Handa ◽  
Akinobu Nakamura ◽  
Aika Miya ◽  
Hiroshi Nomoto ◽  
Hiraku Kameda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Observational Study ◽  
Elderly Patients ◽  
Prospective Observational Study ◽  
Multivariate Logistic Regression Analysis ◽  
Glycemic Variability ◽  
Multivariate Logistic Regression

Abstract Background This study aimed to explore predictive factors of time below target glucose range (TBR) ≥ 1% among patients’ characteristics and glycemic variability (GV) indices using continuous glucose monitoring data in elderly patients with type 2 diabetes. Methods We conducted a prospective observational study on 179 (71 female) Japanese outpatients with type 2 diabetes aged ≥ 65 years. The characteristics of the participants with TBR ≥ 1% were evaluated by multivariate logistic regression analysis. Receiver-operating characteristic (ROC) curve analyses of GV indices, comprising coefficient of variation (CV), standard deviation, and mean amplitude of glycemic excursions, were performed to identify the optimal index for the identification of patients with TBR ≥ 1%. Results In the multivariate logistic regression analysis, none of the clinical characteristics, including HbA1c and C-peptide index, were independent markers for TBR ≥ 1%, while all three GV indices showed significant associations with TBR ≥ 1%. Among the three GV indices, CV showed the best performance based on the area under the curve in the ROC curve analyses. Conclusions Among elderly patients with type 2 diabetes, CV reflected TBR ≥ 1% most appropriately among the GV indices examined. Trial registration UMIN-CTR: UMIN000029993. Registered 16 November 2017

Sulfonylureas as second line treatment for type 2 diabetes

BMJ ◽  
2018 ◽  
pp. k3041 ◽  
Author(s):  
Lucy D’Agostino McGowan ◽  
Christianne L Roumie
Keyword(s):  
Type 2 Diabetes ◽  
Line Treatment ◽  
Second Line
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