scholarly journals Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review

2012 ◽  
Vol 3 (1) ◽  
pp. 42-62 ◽  
Author(s):  
Per Gisle Djupesland
Keyword(s):  
Drug Delivery ◽  
Clinical Perspective ◽  
Nasal Drug Delivery ◽  
And Performance ◽  
Drug Delivery Devices

Development of a nasal cast model to test medicinal nasal devices

2008 ◽  
Vol 222 (7) ◽  
pp. 1013-1022 ◽  
Author(s):  
R Hughes ◽  
J Watterson ◽  
C Dickens ◽  
D Ward ◽  
A Banaszek
Keyword(s):  
Drug Delivery ◽  
Nasal Cavity ◽  
Method Development ◽  
Test Apparatus ◽  
Nasal Drug Delivery ◽  
Nasal Airways ◽  
Cast Model ◽  
Manufacturing Technologies ◽  
Drug Delivery Devices

Bespak, a division of Consort Medical plc, and Queen's University Belfast have developed a viable and unique in-vitro testing capability for nasal drug delivery devices. The aim was to evaluate and optimize current and conceptual drug delivery devices by quantifying the deposition of drug in the various distinct regions of the nasal cavity. The development of this test apparatus employed computed tomography (CT) scan data of the human nasal cavity to construct an accurate representation of the human nasal airways. An investigation of suitable materials and manufacturing technologies was required, together with extensive analytical method development. It is possible for this technique to be further developed in an attempt to create a standardized apparatus based on nasal geometry that can be used to compare accurately deposition from drug delivery devices. This paper presents the issues encountered in the development of this test apparatus, including manufacturing and material limitations, investigation and choice of suitable materials, laboratory testing considerations, and the steps required to validate the analytical process.

scholarly journals 2S6-2　Study of inter nasal drug delivery devices for infants

2016 ◽  
Vol 52 (Supplement) ◽  
pp. S102-S103
Author(s):  
Mikio MURATA ◽  
Kiyoshi KUBOTA ◽  
Kiyomi SADAMOTO
Keyword(s):  
Drug Delivery ◽  
Nasal Drug Delivery ◽  
Drug Delivery Devices

scholarly journals Design and Application in Delivery System of Intranasal Antidepressants

2020 ◽  
Vol 8 ◽  
Author(s):  
Jingying Xu ◽  
Jiangang Tao ◽  
Jidong Wang
Keyword(s):  
Drug Delivery ◽  
Antidepressant Treatment ◽  
Intranasal Delivery ◽  
Nasal Drug Delivery ◽  
Absorption Mechanism ◽  
Antidepressant Treatments ◽  
Systemic Bioavailability ◽  
The Central Nervous System ◽  
Delivery Route ◽  
Drug Delivery Devices

One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central nervous system (CNS). In recent years, nasal drug delivery has achieved better systemic bioavailability and activity in low doses in antidepressant treatment. In this review, we focused on the latest strategies for delivery carriers (or formation) of intranasal antidepressants. We began this review with an overview of the nasal drug delivery systems, including nasal drug delivery route, absorption mechanism, advantages, and limitations in the nasal drug delivery route. Next, we introduced the development of nasal drug delivery devices, such as powder devices, liquid-based devices, and so on. Finally, intranasal delivery carriers of antidepressants in clinical studies, including nanogels, nanostructured lipid, liposomes nanoparticles, nanoemulsions/microemulsion, were summarized. Moreover, challenges and future perspectives on recent progress of intranasal delivery carriers in antidepressant treatments were discussed.

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

Sign in / Sign up

Export Citation Format

Share Document