Knee skin pricking to monitor capillary blood glucose is less painful than finger pricking in children with type 1 diabetes

Background: Fructose has been widely used for producing lower post-infusion glucose increase than other carbohydrates, but seems that it promotes an increase in post-infusion triglycerides. Objective: The present study investigated the effects of fructose and glucose in metabolic variables and appetite sensations in patients with type 1 diabetes mellitus (T1DM). Methods: This is a single-blind, randomized and crossover study (washout of 1-5 weeks), which has evaluated 16 adult T1DM patients, accompanied at University Hospital. After eight hours overnight fasting, were assessment of capillary blood glucose, anthropometric variables, appetite sensations and laboratory tests (glycemia, lipemia, leptin and glucagon). Subsequently, they received 200mL of solutions with water and 75g of crystal fructose or glucose. Appetite sensations and capillary blood glucose were evaluated in different post-infusion times. Blood was drawn after 180 minutes for the laboratory tests. Results: Blood glucose increased after the intake of both solutions, but the glucose induced a higher elevation. None of them increased triglycerides or glucagon. Glucagon maintenance was similar among the solutions. Furthermore, both solutions reduced leptin and increased fullness, but only fructose increased lack of interest in eating sweets. Conclusions: Fructose induced smaller increase in postprandial blood glucose than glucose, without changes in triglycerides and glucagon. In addition, leptin levels and appetite sensations were similar to glucose. Other studies are needed in order to confirm these findings, especially in the long term, so that their use becomes really reliable.

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Minimizing postprandial hypoglycemia in Type 1 diabetes patients using multiple insulin injections and capillary blood glucose self-monitoring with machine learning techniques

Computer Methods and Programs in Biomedicine ◽

10.1016/j.cmpb.2019.06.025 ◽

2019 ◽

Vol 178 ◽

pp. 175-180 ◽

Cited By ~ 4

Author(s):

Silvia Oviedo ◽

Ivan Contreras ◽

Arthur Bertachi ◽

Carmen Quirós ◽

Marga Giménez ◽

...

Keyword(s):

Machine Learning ◽

Type 1 Diabetes ◽

Blood Glucose ◽

Capillary Blood ◽

Machine Learning Techniques ◽

Capillary Blood Glucose ◽

Self Monitoring ◽

Learning Techniques ◽

Blood Glucose Self Monitoring

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Differences for Percentage Times in Glycemic Range Between Continuous Glucose Monitoring and Capillary Blood Glucose Monitoring in Adults with Type 1 Diabetes: Analysis of the REPLACE-BG Dataset

Diabetes Technology & Therapeutics ◽

10.1089/dia.2019.0276 ◽

2020 ◽

Vol 22 (3) ◽

pp. 222-227 ◽

Cited By ~ 5

Author(s):

Parizad Avari ◽

Chukwuma Uduku ◽

Daniel George ◽

Pau Herrero ◽

Monika Reddy ◽

...

Keyword(s):

Type 1 Diabetes ◽

Blood Glucose ◽

Continuous Glucose Monitoring ◽

Glucose Monitoring ◽

Capillary Blood ◽

Blood Glucose Monitoring ◽

Capillary Blood Glucose

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Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?

Journal of Clinical Medicine ◽

10.3390/jcm10214913 ◽

2021 ◽

Vol 10 (21) ◽

pp. 4913

Author(s):

Rocio Porcel-Chacón ◽

Cristina Antúnez-Fernández ◽

Maria Mora Loro ◽

Ana-Belen Ariza-Jimenez ◽

Leopoldo Tapia Ceballos ◽

...

Keyword(s):

Type 1 Diabetes ◽

Blood Glucose ◽

Metabolic Control ◽

Glycated Hemoglobin ◽

Glucose Monitoring ◽

Capillary Blood ◽

Capillary Blood Glucose ◽

Good Metabolic Control ◽

One Year

Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, p < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets.

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Evaluation of the clinical safety and analytical reliability of blood glucose self-control tools "Glucocard Sigma" and "Glucocard Sigma-mini" in type 1 diabetes children.

Problems of Endocrinology ◽

10.14341/probl201763117-22 ◽

2017 ◽

Vol 63 (1) ◽

pp. 17-22

Author(s):

Ekaterina A. Andrianova ◽

Aleksandr V. Ilyin ◽

Tamara L. Kuraeva ◽

Valentina A. Peterkova

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Blood Glucose ◽

Glucose Level ◽

Capillary Blood ◽

Clinical Safety ◽

Analytical Accuracy ◽

Biochemical Analyzer ◽

Glucose Meter

Rationale. Arkray blood glucose meters have become widely used in Russia since 2013. Studies focused on their accuracy, where Arkray Glucocard II glucose meter is used as the reference monitoring system, have been published. Since insulin dose to be injected relies upon readings of a personal blood glucose meter, the system being used must comply with the clinical safety and analytical accuracy criteria for glucose meters. Objective — to assess clinical safety and analytical accuracy of the results of studying blood glucose level measured using Glucocard Sigma and Glucocard Sigma Mini blood glucose meters. Material and methods. Glucose level in a drop of capillary blood was studied in 48 pediatric and adolescent patients with type 1 diabetes mellitus (DMT1). The mean age of the patients was 9.4±5.6 years; average duration of the disease, 4.2±2.7 years. Parallel studies on glycaemia using the Glucocard Sigma and Glucocard Sigma Mini glucose meters being tested, as well as a BIOSEN C-line stationary biochemical analyzer system, were carried out at the Department of Diabetes Mellitus of the Institute of Pediatric Endocrinology and the Biochemical Laboratory of the Endocrinology Research Center of the Ministry of Healthcare of the Russian Federation. A total of 320 samples were examined. The hexokinase method performed on a BIOSEN C-line biochemical analyzer system was used as the reference method for measuring blood glucose level. Results. Assessment of clinical safety demonstrated that 100% of test results belonged to zone A (will not result in patient error) and B (will not result in patient error or there will be a minor error not affecting patient’s condition). These findings fully comply with the ISO 15197-2016 standard. Investigation of the analytical accuracy of Glucocard Sigma and Glucocard Sigma Mini glucose meters (capillary blood, glucose blood level >4.2 mmol/L) compared to the results obtained using the BIOSEN C-line biochemical analyzer system showed a <5% deviation in 118 (51.3%) measurements; <10%, in 202 (87.8%) measurements; less than 15%, 222 (96.5%) measurements; and less than 20%, in 230 (100%) measurements. These results comply both with the ISO 15197-2015 criteria and stricter criteria ISO 15197-2016. Conclusion. The high accuracy of Glucocard Sigma and Glucocard Sigma Mini glucose meters has been confirmed. The accuracy of these glucose meters complies with the State Standard GOST ISO 15197-2015 and the ISO 15197-2016 standard.

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