Utility of urinary progranulin in patients with type 2 diabetic nephropathy and its correlation with renal function

2021 ◽  
Author(s):  
Abhishek Rai ◽  
Gandhipuram Periyasamy Senthilkumar ◽  
Vadivelan Mehalingam
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Type 2 Diabetic

Spironolactone in type 2 diabetic nephropathy: effects on proteinuria, blood pressure and renal function

2006 ◽  
Vol 24 (11) ◽  
pp. 2285-2292 ◽  
Author(s):  
Anton H van den Meiracker ◽  
Rini GA Baggen ◽  
Sacha Pauli ◽  
Anouk Lindemans ◽  
Arnold G Vulto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Type 2 Diabetic

scholarly journals Evaluation of urinary L-FABP as an early marker for diabetic nephropathy in type 2 diabetic patients

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Duong Thi Thuy Ngan ◽  
Nguyen Gia Binh ◽  
Le Thi Huong Lan ◽  
Cuc Thi Thu Nguyen ◽  
Phung Thanh Huong
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Early Detection ◽  
Urinary Albumin ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Fatty Acid Binding ◽  
Type 2 Diabetic

Summary Background Albuminuria is the standard biomarker for the diagnosis of diabetic nephropathy (DN). However, some patients with persistent microalbuminuria still progress to chronic kidney disease, raising the question of finding a better biomarker. This study aimed to evaluate the correlation of urinary liver-type fatty acid-binding protein (L-FABP) levels with renal function and to compare the role of urinary albumin-to-creatinine ratio (ACR) with urinary L-FABP in early detection of DN in type 2 diabetic patients. Methods The cross-sectional study was done on 106 type 2 diabetic patients and 30 non-diabetic people. L-FABP was measured with the Latex enhanced immunoturbidimetric technique. Results There was a strong and negative correlation between the urine L-FABP levels and eGFR (r = -0.606, p<0.001). The urinary L-FABP levels were significantly higher (p<0.001) in the normoalbuminuria diabetic group than the non-diabetic control group. The ROC-curve analyses in the diabetic patients and the normoalbuminuria diabetic patients showed that the AUCL-FABP was remarkably higher (p<0.001) than the AUCACR. An optimal cutoff value of 5 mg L-FABP/g Cr (with the sensitivity of 98.1% and specificity of 90%) and of 4.3 mg L-FABP/g Cr (with the sensitivity of 100% and specificity of 86.67%) was set to detect DN in the diabetic patients and the normoalbuminuria diabetic patients, respectively. Conclusions The change in urinary L-FABP levels happened earlier than in urinary albumin during renal function impairment. Urinary L-FABP can be used as a better indicator than ACR for early detection of DN in type 2 diabetes.

Omentin-1 protects renal function of mice with type 2 diabetic nephropathy via regulating miR-27a-Nrf2/Keap1 axis

2018 ◽  
Vol 107 ◽  
pp. 440-446 ◽  
Author(s):  
Juan Song ◽  
Hongxia Zhang ◽  
Yanni Sun ◽  
Ruimin Guo ◽  
Dongxiang Zhong ◽  
...  
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Type 2 Diabetic

scholarly journals Improvement of Renal Function in Type 2 Diabetic Nephropathy

Renal Failure ◽  
2007 ◽  
Vol 29 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Narisa Futrakul ◽  
Punnee Butthep ◽  
Prasit Futrakul ◽  
Visith Sitprija
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Type 2 Diabetic

scholarly journals Enhanced Peritubular Capillary Flow and Renal Function Can Be Accomplished in Normoalbuminuric Type 2 Diabetic Nephropathy

Renal Failure ◽  
2011 ◽  
Vol 33 (3) ◽  
pp. 312-315 ◽  
Author(s):  
N. Futrakul ◽  
O. Kulaputana ◽  
P. Futrakul ◽  
A. Chavanakul ◽  
T. Deekajorndech
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Capillary Flow ◽  
Peritubular Capillary ◽  
Type 2 Diabetic

scholarly journals Association between Protein Kinase C –B Isoform Level and Insulin Resistance in Pathogenesis of Iraqi Patients with Type 2 Diabetic Nephropathy Complications

2021 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Insulin Resistance ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Blood Glucose ◽  
Function Tests ◽  
Significant Difference ◽  
Healthy Control ◽  
Renal Function Tests ◽  
Type 2 Diabetic

Objective: The aim of the present study is to evaluate the association between serum PKC-B isoform activity levels and various biomarkers such as insulin resistance in sera of Iraqi patients with diabetic nephropathy complications. Methods: A cross-sectional study was performed on 100 samples obtained from Al-Hussein Teaching Hospital, Al-Hussein Medical City, Kerbala Health Directorates / Kerbala – Iraq during Nov., 2019 to Sep. 2020. Thirty patients have type 2 diabetic nephropathy, 40 patients with type 2 diabetic without nephropathy and 30 samples as apparently healthy control. Biochemical data, comprising serum PKC-B level, lipid profile, blood glucose, insulin, HOMA-IR and renal function tests such as urea, creatinine and GFR were investigated. Results: The study included 63% male and 37% female. The results indicated that there was a significant difference in blood glucose, HbA1c%, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), urea, creatinine, GFR and PKC-B between diabetic nephropathy and non-diabetic nephropathy groups (P-value <0.05). Serum PKC-B activity was significantly correlated with blood glucose, HOMA-IR, creatinine and GFR among diabetic nephropathy group, while, HbA1c% and blood glucose was positively correlated with PKC-B level in non-diabetic nephropathy group. Conclusion: The observed data conclude that PKC-B level is higher in patients with diabetic nephropathy complication as compared with T2DM and healthy control. Also there is a significant correlation between PKC-B level and renal function tests in DN group which indicate an important role of PKC-B level in pathogenesis of diabetic nephropathy complications.

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