scholarly journals An extremely rare salivary gland tumor: intraductal carcinoma of the buccal mucosa

2015 ◽  
Vol 5 (1) ◽  
pp. 53-56
Author(s):  
Junya Nojima ◽  
Mitsuhiko Nakahira ◽  
Hiroshi Yamaguchi ◽  
Shoichiro Kokabu ◽  
Tetsuya Yoda ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Buccal Mucosa ◽  
Salivary Gland Tumor ◽  
Intraductal Carcinoma ◽  
Gland Tumor

scholarly journals Low-grade Apocrine Intraductal Carcinoma: Expanding the Morphologic and Molecular Spectrum of an Enigmatic Salivary Gland Tumor

2020 ◽  
Vol 14 (4) ◽  
pp. 869-875 ◽  
Author(s):  
Justin A. Bishop ◽  
Jeffrey Gagan ◽  
Jeffrey F. Krane ◽  
Vickie Y. Jo
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Molecular Spectrum ◽  
Intraductal Carcinoma ◽  
Low Grade ◽  
Gland Tumor

Frankly Invasive Carcinoma Ex-intraductal Carcinoma: Expanding on an Emerging and Perplexing Concept in Salivary Gland Tumor Pathology

2022 ◽  
Author(s):  
Anne C. McLean-Holden ◽  
Lisa M. Rooper ◽  
Daniel J. Lubin ◽  
Kelly R. Magliocca ◽  
Varsha Manucha ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Invasive Carcinoma ◽  
Salivary Gland Tumor ◽  
Intraductal Carcinoma ◽  
Gland Tumor ◽  
Tumor Pathology

Addendum to “Clinical analysis of salivary gland tumor cases in West China in past 50 years” [Oral Oncol. 44 (2) (2008) 187–192]

Oral Oncology ◽  
2011 ◽  
Vol 47 (9) ◽  
pp. 929-930 ◽  
Author(s):  
Long-jiang Li ◽  
Yi Li ◽  
Yu-ming Wen ◽  
Hua Liu ◽  
Hong-wei Zhao
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Clinical Analysis ◽  
Gland Tumor ◽  
West China

First Insights into the Molecular Basis of Pleomorphic Adenomas of the Salivary Glands

2000 ◽  
Vol 14 (1) ◽  
pp. 81-83 ◽  
Author(s):  
M.L. Voz ◽  
W.J.M. Van de Ven ◽  
K. Kas
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Benign Tumor ◽  
Salivary Gland Tumor ◽  
Transitional Zone ◽  
Chromosome 8 ◽  
Gland Tumor ◽  
Histopathological Classification ◽  
Pleomorphic Adenomas ◽  
Chromosomal Changes

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is composed of tumors with various translocations involving 12ql5. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8ql2. The most frequently encountered aberration in this group is a t(3;8)(p21;q12).

scholarly journals N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 45
Author(s):  
Candace A. Frerich ◽  
Hailey N. Sedam ◽  
Huining Kang ◽  
Yoshitsugu Mitani ◽  
Adel K. El-Naggar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Transcriptional Activity ◽  
Perineural Invasion ◽  
Salivary Gland Tumor ◽  
Rna Seq ◽  
Gland Tumor ◽  
Adenoid Cystic ◽  
Myb Proteins ◽  
Tumor Types

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland tumor that frequently displays perineural invasion and is often associated with translocations or overexpression of the MYB oncogene. Detailed analyses of MYB transcripts from ACC patient samples revealed that ACC tumors utilize an alternative MYB promoter, which is rarely used in normal cells or other tumor types. The alternative promoter transcripts produce N-terminally truncated Myb proteins lacking a highly conserved and phosphorylated domain, which includes the pS11 epitope that is frequently used to detect Myb proteins. In RNA-seq assays, Myb isoforms lacking the N-terminal domain displayed unique transcriptional activities, regulating many genes differently than full-length Myb. Thus, a regulatory pathway unique to ACC activates the alternative MYB promoter, leading to the production of a truncated Myb protein with altered transcriptional activities. This could provide new therapeutic opportunities for ACC patients.

scholarly journals An Interesting Case of Hodgkin\'s Lymphoma Presenting as Salivary Gland Tumor

2021 ◽  
Vol 12 (2) ◽  
pp. 89-91
Author(s):  
Tharun Ganapathy Chitrambalam ◽  
Sidhu Sekhar ◽  
Preetham Anguraj ◽  
Koshy M Panicker
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Interesting Case ◽  
Gland Tumor

scholarly journals Presence of Human Beta-Defensin 2 Peptide in Keratinization in Salivary Gland Tumor.

2000 ◽  
Vol 5 (2) ◽  
pp. 95-97 ◽  
Author(s):  
Yoshihiro Abiko ◽  
Michiko Nishimura ◽  
Kaoru Kusano ◽  
Tohru Kaku
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Gland Tumor

Postirradiation Malignant Salivary Gland Tumor

1976 ◽  
Vol 102 (11) ◽  
pp. 699 ◽  
Author(s):  
Dale H. Rice ◽  
John G. Batsakis ◽  
Kenneth D. McClatchey
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Gland Tumor ◽  
Malignant Salivary Gland Tumor

Intraductal Papillary Tumors of the Major Salivary Glands

2000 ◽  
Vol 124 (2) ◽  
pp. 291-295 ◽  
Author(s):  
Toshitaka Nagao ◽  
Isamu Sugano ◽  
Osamu Matsuzaki ◽  
Hitoshi Hara ◽  
Yoichiro Kondo ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Salivary Gland Tumor ◽  
Papillary Adenocarcinoma ◽  
Intraductal Papilloma ◽  
Gland Tumor ◽  
Ki 67 ◽  
Parotid Gland Tumor ◽  
Invasive Component ◽  
Papillary Structure

Abstract Intraductal papilloma is an extremely rare benign salivary gland tumor that occurs most commonly in the minor salivary glands. To our knowledge, a malignant counterpart of intraductal papilloma has not been described previously. We report one case each of benign and malignant intraductal papillary tumors. The benign tumor occurred in the sublingual gland and was a typical example of intraductal papilloma, with the exception that we found no previously published reports of this type of tumor in this location. The other patient had a left parotid gland tumor that was architecturally similar to the intraductal papilloma, with the addition of cytologic atypia, intraductal extension, microinvasion, and lymph node metastases. This tumor was diagnosed as intraductal papillary adenocarcinoma with an invasive component. Both patients were alive and well without evidence of recurrence 2 years and 6 months (case 1) and 6 years (case 2) after surgery. Immunohistochemical examination revealed that the tumor cells resembled duct luminal cells in both cases. The 2 tumors had different immunoreactivities for carcinoembryonic antigen, p53, and Ki-67. The malignant counterpart of intraductal papilloma should be considered in the differential diagnosis of salivary gland tumors with a predominantly papillary structure, even though this tumor is extremely rare.

Sign in / Sign up

Export Citation Format

Share Document