scholarly journals Low-grade Apocrine Intraductal Carcinoma: Expanding the Morphologic and Molecular Spectrum of an Enigmatic Salivary Gland Tumor

2020 ◽  
Vol 14 (4) ◽  
pp. 869-875 ◽  
Author(s):  
Justin A. Bishop ◽  
Jeffrey Gagan ◽  
Jeffrey F. Krane ◽  
Vickie Y. Jo
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Molecular Spectrum ◽  
Intraductal Carcinoma ◽  
Low Grade ◽  
Gland Tumor

Frankly Invasive Carcinoma Ex-intraductal Carcinoma: Expanding on an Emerging and Perplexing Concept in Salivary Gland Tumor Pathology

2022 ◽  
Author(s):  
Anne C. McLean-Holden ◽  
Lisa M. Rooper ◽  
Daniel J. Lubin ◽  
Kelly R. Magliocca ◽  
Varsha Manucha ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Invasive Carcinoma ◽  
Salivary Gland Tumor ◽  
Intraductal Carcinoma ◽  
Gland Tumor ◽  
Tumor Pathology

scholarly journals Low Grade Central Mucoepidermoid Carcinoma

2015 ◽  
Vol 5 (1) ◽  
pp. 31-34
Author(s):  
Kartik Poonja ◽  
Janaki Subramanian Iyer ◽  
Leela Poonja
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Male Patient ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumor ◽  
Malignant Neoplasm ◽  
Low Grade ◽  
Gland Tumor ◽  
Malignant Salivary Gland Tumor ◽  
Central Mucoepidermoid Carcinoma

ABSTRACT Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, comprising about 15% of all salivary gland tumors and 30% of all salivary malignancies. Most of the MEC arise in the parotid gland. Rarely, it originates in the mandible and maxilla as an intraosseous variant, referred to as ‘central mucoepidermoid carcinoma’ or ‘intraosseous mucoepidermoid carcinoma’. Central mucoepidermoid carcinomas (CMECs) are extremely rare, but well-known entity, comprising 2 to 3% of all MECs reported. Histopathologically, this malignant neoplasm is characterized by mucous, intermediate and epidermoid cells. In this report, we present a case of a male patient diagnosed as low grade CMEC. How to cite this article Iyer JS, Poonja K, Pathak J, Patel S, Poonja L. Low Grade Central Mucoepidermoid Carcinoma. J Contemp Dent 2015;5(1):31-34.

scholarly journals An extremely rare salivary gland tumor: intraductal carcinoma of the buccal mucosa

2015 ◽  
Vol 5 (1) ◽  
pp. 53-56
Author(s):  
Junya Nojima ◽  
Mitsuhiko Nakahira ◽  
Hiroshi Yamaguchi ◽  
Shoichiro Kokabu ◽  
Tetsuya Yoda ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Buccal Mucosa ◽  
Salivary Gland Tumor ◽  
Intraductal Carcinoma ◽  
Gland Tumor

Addendum to “Clinical analysis of salivary gland tumor cases in West China in past 50 years” [Oral Oncol. 44 (2) (2008) 187–192]

Oral Oncology ◽  
2011 ◽  
Vol 47 (9) ◽  
pp. 929-930 ◽  
Author(s):  
Long-jiang Li ◽  
Yi Li ◽  
Yu-ming Wen ◽  
Hua Liu ◽  
Hong-wei Zhao
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Clinical Analysis ◽  
Gland Tumor ◽  
West China

First Insights into the Molecular Basis of Pleomorphic Adenomas of the Salivary Glands

2000 ◽  
Vol 14 (1) ◽  
pp. 81-83 ◽  
Author(s):  
M.L. Voz ◽  
W.J.M. Van de Ven ◽  
K. Kas
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Benign Tumor ◽  
Salivary Gland Tumor ◽  
Transitional Zone ◽  
Chromosome 8 ◽  
Gland Tumor ◽  
Histopathological Classification ◽  
Pleomorphic Adenomas ◽  
Chromosomal Changes

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is composed of tumors with various translocations involving 12ql5. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8ql2. The most frequently encountered aberration in this group is a t(3;8)(p21;q12).

scholarly journals N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 45
Author(s):  
Candace A. Frerich ◽  
Hailey N. Sedam ◽  
Huining Kang ◽  
Yoshitsugu Mitani ◽  
Adel K. El-Naggar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Transcriptional Activity ◽  
Perineural Invasion ◽  
Salivary Gland Tumor ◽  
Rna Seq ◽  
Gland Tumor ◽  
Adenoid Cystic ◽  
Myb Proteins ◽  
Tumor Types

Adenoid cystic carcinoma (ACC) is an aggressive salivary gland tumor that frequently displays perineural invasion and is often associated with translocations or overexpression of the MYB oncogene. Detailed analyses of MYB transcripts from ACC patient samples revealed that ACC tumors utilize an alternative MYB promoter, which is rarely used in normal cells or other tumor types. The alternative promoter transcripts produce N-terminally truncated Myb proteins lacking a highly conserved and phosphorylated domain, which includes the pS11 epitope that is frequently used to detect Myb proteins. In RNA-seq assays, Myb isoforms lacking the N-terminal domain displayed unique transcriptional activities, regulating many genes differently than full-length Myb. Thus, a regulatory pathway unique to ACC activates the alternative MYB promoter, leading to the production of a truncated Myb protein with altered transcriptional activities. This could provide new therapeutic opportunities for ACC patients.

scholarly journals An Interesting Case of Hodgkin\'s Lymphoma Presenting as Salivary Gland Tumor

2021 ◽  
Vol 12 (2) ◽  
pp. 89-91
Author(s):  
Tharun Ganapathy Chitrambalam ◽  
Sidhu Sekhar ◽  
Preetham Anguraj ◽  
Koshy M Panicker
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Interesting Case ◽  
Gland Tumor

scholarly journals Presence of Human Beta-Defensin 2 Peptide in Keratinization in Salivary Gland Tumor.

2000 ◽  
Vol 5 (2) ◽  
pp. 95-97 ◽  
Author(s):  
Yoshihiro Abiko ◽  
Michiko Nishimura ◽  
Kaoru Kusano ◽  
Tohru Kaku
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Gland Tumor

scholarly journals Mammary analogue secretory carcinoma: a rare salivary gland tumor

2020 ◽  
Vol 6 (5) ◽  
pp. 998
Author(s):  
Shashikant Anil Pol ◽  
Surinder K. Singhal ◽  
Nitin Gupta ◽  
Himanshu Bayad
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Good Prognosis ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Grade Malignancy ◽  
Enhanced Computed Tomography ◽  
Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

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