scholarly journals A long-term survival case with proton beam therapy for advanced sphenoid sinus cancer with hypopituitarism

2021 ◽  
Author(s):  
Yojiro Ishikawa ◽  
Motohisa Suzuki ◽  
Hisashi Yamaguchi ◽  
Ichiro Seto ◽  
Masanori Machida ◽  
...  
Keyword(s):  
Proton Beam ◽  
Sphenoid Sinus ◽  
Proton Beam Therapy ◽  
Term Survival ◽  
Optic Chiasma ◽  
Acute Side Effect ◽  
Radiation Induced ◽  
Biological Effectiveness ◽  
Sinus Cancer

AbstractSphenoid sinus malignancies are rare diseases. Secondary hypopituitarism associated with sphenoid sinus malignancy is not well known. A 41-year-old male complained of right ptosis. Neurological findings revealed right oculomotor, trochlear and glossopharyngeal nerve palsy. Imaging diagnosis suggested a tumor that had spread bilaterally from the sphenoid sinus to the ethmoid sinus, nasopharynx and posterior pharyngeal space. Biopsy revealed squamous cell carcinoma (SCC). Based on these findings, a clinical diagnosis of SCC of the sphenoid sinus was made. Removal of the tumor without damaging nearby organs would have been difficult because the tumor extended to the bilateral optic nerves, optic chiasma and internal carotid artery, and surgeons, therefore, recommended proton beam therapy (PBT). Before PBT, the hypopituitarism occurred in the patient and we administered hydrocortisone and levothyroxine. During treating for hypopituitarism, we performed PBT with nedaplatin and 5-fluorouracil. The daily PBT fractions were 2.2 relative biological effectiveness (RBE) for the tumor received total dose of 81.4 Gy RBE. The acute side effect of grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Occurred after PBT. The patient needs to take hydrocortisone and levothyroxine, but he remains in complete remission 8 years after treatment without surgery or chemotherapy. Visual function is gradually declining, but there is no evidence of severe radiation-induced optic neuropathy.

scholarly journals PS1 - 183 Recommendations for the Referral of Patients from Proton Beam Therapy, an Alberta Health Services Report: A Model for Canada?

2016 ◽  
Vol 43 (S4) ◽  
pp. S11-S11
Author(s):  
S. Patel ◽  
X. Kostaras ◽  
M. Parliament ◽  
I.A. Olivotto ◽  
R. Nordal ◽  
...  
Keyword(s):  
Health Services ◽  
Proton Beam ◽  
Proton Therapy ◽  
Proton Beam Therapy ◽  
Sufficient Evidence ◽  
Draft Report ◽  
Term Survival ◽  
Travel Abroad ◽  
Alberta Health

Proton beam therapy (PBT) offers compelling advantages in physical dose distribution compared to photon therapy. There are increasing numbers of gantry-based proton facilities worldwide but no such facilities exist in Canada. To access PBT, Canadian patients must travel abroad for treatment at high cost. In the face of limited access, this report seeks to provide recommendations for the selection of patients most likely to benefit from PBT and suggests an out-of-country referral process. METHODS: A systematic literature search for studies between January 1990 and May 2014 evaluating clinical outcomes after PBT. A draft report was developed through review of evidence, externally reviewed, and approved by the Alberta Health Services Cancer Care Proton Therapy Guidelines steering committee. RESULTS: Proton therapy is often used to treat tumours close to radiosensitive tissues, and children at risk of developing significant late effects of radiation therapy (RT). Local control rates with PBT appear similar to or, in some cases, higher than photon RT in uncontrolled and retrospective studies. Randomized trials comparing equivalent doses of PBT and photon RT are not available. SUMMARY: Referral for PBT is recommended for patients being treated with curative intent, with an expectation for long-term survival, and who are able and willing to travel abroad to a proton facility. Commonly accepted indications for referral include chordoma and chondrosarcoma, intraocular melanoma, and solid tumours in children and adolescents occurring in patients with greatest risk of long-term sequelae. Current data do not provide sufficient evidence to recommend routine referral of patients with most head and neck, breast, lung, gastrointestinal tract, and pelvic cancers including prostate cancer. It is recommended that all referrals be considered by a multidisciplinary team to select appropriate cases.

Long-term survival after treatment of glioblastoma multiforme with hyperfractionated concomitant boost proton beam therapy

2015 ◽  
Vol 5 (1) ◽  
pp. e9-e16 ◽  
Author(s):  
Masashi Mizumoto ◽  
Tetsuya Yamamoto ◽  
Shingo Takano ◽  
Eiichi Ishikawa ◽  
Akira Matsumura ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Proton Beam ◽  
Proton Beam Therapy ◽  
Term Survival ◽  
Long Term Survival ◽  
Concomitant Boost

Tumor and Dosimetric Predictors of Long-Term Visual Outcomes After Proton Beam Therapy of Uveal Melanoma

2014 ◽  
Vol 90 (1) ◽  
pp. S305 ◽  
Author(s):  
A.L. Polishchuk ◽  
D.H. Char ◽  
V. Weinberg ◽  
I.K. Daftari ◽  
T.B. Cole ◽  
...  
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Proton Beam Therapy ◽  
Visual Outcomes

Long-Term Effects of Proton Beam Therapy for Acromegaly

Acromegaly ◽  
1987 ◽  
pp. 221-228 ◽  
Author(s):  
Bernard Kliman ◽  
Raymond N. Kjellberg ◽  
Billie Swisher ◽  
William Butler
Keyword(s):  
Proton Beam ◽  
Proton Beam Therapy ◽  
Long Term Effects

scholarly journals Proton beam therapy for malignant transformation of intracranial epidermoid cyst

2019 ◽  
Vol 12 (7) ◽  
pp. e229388
Author(s):  
Zhe Chen ◽  
Masayuki Araya ◽  
Hiroshi Onishi
Keyword(s):  
Proton Beam ◽  
Malignant Transformation ◽  
Epidermoid Cyst ◽  
Clinical Case ◽  
Proton Beam Therapy ◽  
Facial Paresis ◽  
Surgical Interventions ◽  
Radiation Induced ◽  
Intracranial Epidermoid

We report the first clinical case on the successful use of proton beam therapy in the management of malignant transformation of intracranial epidermoid cyst. A 43-year-old man was initially diagnosed as this disease with left facial paresis, hypesthesia and hypoalgesia in the territories of the trigeminal nerve. After failure of surgical interventions, he was referred to our radiation centre. We performed a postoperative proton beam therapy for treatment. We delivered a total dose of 57 GyE in 31 fractions. He tolerated the treatment well with mild acute toxicities and remained healthy and functional by 2-year follow-up postradiotherapy. No evidence of delayed radiation-induced neurotoxicity was observed.

scholarly journals Dosimetric advantages of proton beam therapy compared to intensity-modulated radiation therapy for retroperitoneal chordoma

Rare Tumors ◽  
2019 ◽  
Vol 11 ◽  
pp. 203636131987851 ◽  
Author(s):  
Nathan Y Yu ◽  
Sujay A Vora
Keyword(s):  
Radiation Therapy ◽  
Proton Beam ◽  
Intensity Modulated Radiation Therapy ◽  
Proton Beam Therapy ◽  
Intensity Modulated ◽  
Spot Scanning ◽  
Prescription Dose ◽  
Biological Effectiveness ◽  
Primary Bone ◽  
Rare Diagnosis

Retroperitoneal chordomas are exceedingly rare and account for less than 5% of all primary bone malignancies. Their etiology remains unknown. We report a rare case of an extravertebral chordoma of the retroperitoneum in a 71-year-old man treated with surgical resection and post-operative spot-scanning proton beam therapy. We describe how to safely treat a retroperitoneal target to a prescription dose over 70 Gy (relative biological effectiveness) with spot-scanning proton beam therapy and also report a dosimetric comparison of spot-scanning proton beam therapy versus intensity-modulated radiation therapy. This case not only highlights a rare diagnosis of an extravertebral retroperitoneal chordoma but it also draws attention to the dosimetric advantages of proton beam therapy and illustrates a promising radiotherapeutic option for retroperitoneal targets.

Long-term Outcomes After Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma

2013 ◽  
Vol 87 (2) ◽  
pp. S457-S458 ◽  
Author(s):  
A.L. Russo ◽  
M. Truong ◽  
P.M. Busse ◽  
J. Adams ◽  
D.G. Deschler ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proton Beam ◽  
Squamous Cell ◽  
Proton Beam Therapy ◽  
Long Term Outcomes

Long-term results of proton beam therapy for carcinoma of the uterine cervix

2003 ◽  
Vol 55 (5) ◽  
pp. 1265-1271 ◽  
Author(s):  
Kenji Kagei ◽  
Koichi Tokuuye ◽  
Toshiyuki Okumura ◽  
Kiyoshi Ohara ◽  
Yoshiyuki Shioyama ◽  
...  
Keyword(s):  
Proton Beam ◽  
Uterine Cervix ◽  
Proton Beam Therapy ◽  
Long Term Results
Sign in / Sign up

Export Citation Format

Share Document