HCV–HIV coinfected pregnant women: data from a multicentre study in Italy

Abstract Non-invasive prenatal testing (NIPT) is a fast, safe, and non-disruptive diagnostic method. At present, few studies have evaluated the screening efficiency of NIPT positive predictive value (PPV) in study subjects. Here, the results of NIPT in pregnant women were retrospectively analysed, and the detection rate, PPV and follow-up data were evaluated to determine its clinical value. A large multicentre study was conducted involving 52,855 pregnant women who received NIPT. Based on gestational age, amniotic fluid or umbilical cord blood were extracted for simultaneous karyotype and chromosome microarray analysis (CMA) in NIPT-positive patients. Among the 52,855 cases, 754 were NIPT-positive, with a positivity rate of 1.4%. Karyotype analysis and/or CMA confirmed 323 cases of chromosomal abnormalities, with a PPV of 45.1%. PPV of Trisomy 21 (T21), Trisomy 18 (T18), Trisomy 13 (T13), sex chromosomal aneuploidies (SCA) and copy number variations (CNV) were 78.9%, 35.3%, 22.2%, 36.9% and 32.9%, respectively. The PPV of T21, T18, and T13 increased with age whereas, the PPV of SCA and CNVs had little correlation with age. The PPV was significantly high in patients with advanced age along with an abnormal ultrasound.NIPT had a high PPV for T21, and a low PPV for T13 and T18, while screening for SCA and CNVs showed clinical significance. However, in case of NIPT screening for SCA and CNVs, simultaneous karyotype and CMA should be performed to increase the detection rates. Interventional prenatal diagnosis is still required in NIPT-positive cases to avoid false positives or unnecessary termination of pregnancy.

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Comparison of HbA1c and glycated albumin as a control marker for newborn complications in diabetic women in a multicentre study in Japan (Japan glycated albumin study group: study 2)

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563218763695 ◽

2018 ◽

Vol 55 (6) ◽

pp. 639-646 ◽

Cited By ~ 7

Author(s):

Ikki Shimizu ◽

Yuji Hiramatsu ◽

Yasue Omori ◽

Masao Nakabayashi ◽

Keyword(s):

Multicentre Study ◽

Pregnant Women ◽

Plasma Glucose ◽

Glycated Albumin ◽

Reference Interval ◽

Glycated Haemoglobin ◽

Respiratory Disorder ◽

Neonatal Complications

Background To clarify the relationship between glycated haemoglobin and glycated albumin concentrations during pregnancy with neonatal outcomes, a multicentre study was conducted by the Japanese Society of Diabetes and Pregnancy. Methods A total of 136 patients (type 1: n = 47, type 2: n = 89) who enrolled in the study were diagnosed based on the Japanese Diabetes Society diagnostic criteria for diabetes mellitus. Thresholds for glycated haemoglobin and glycated albumin were set at 5.8% and 15.8%, respectively, as the upper limits of the reference interval in pregnant women. Result Random plasma glucose decreased linearly, and reached the reference interval at 40 weeks. Glycated albumin concentrations also decreased in the same manner. But glycated haemoglobin concentrations were out of the reference interval during the study. The frequency of the neonatal complications did not show significant differences between the glycated haemoglobin ⩾5.8% group and the glycated haemoglobin <5.8% group. On the other hand, the frequency of neonatal complications showed higher tendency of neonatal complications in the incidence of polycythaemia ( P = 0.094) and heavy-for-date ( P = 0.071) in the glycated albumin ⩾15.8% group compared with the glycated albumin <15.8 group. The respiratory disorder in type 1 diabetes was significantly higher than type 2 diabetes. Conclusions For the treatment of pregnant women with diabetes, glycated albumin would be a better marker than glycated haemoglobin. However, glycated albumin is also affected by obesity and albumin, and it is desirable to make a comprehensive judgment with glycated haemoglobin, random plasma glucose and other glycaemic index.

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Herbal medicine use among pregnant women attending antenatal clinics in Lusaka Province, Zambia: A cross-sectional, multicentre study

Complementary Therapies in Clinical Practice ◽

10.1016/j.ctcp.2020.101218 ◽

2020 ◽

Vol 40 ◽

pp. 101218

Author(s):

Magalie El Hajj ◽

Doreen Chilolo Sitali ◽

Bellington Vwalika ◽

Lone Holst

Keyword(s):

Herbal Medicine ◽

Multicentre Study ◽

Pregnant Women ◽

Medicine Use ◽

Cross Sectional ◽

Antenatal Clinics ◽

Lusaka Province

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OP03.07: Ultrasonographic evaluation of ovarian mass for prediction of malignancy in pregnant women: comparison of scoring systems in a multicentre study

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.20674 ◽

2019 ◽

Vol 54 (S1) ◽

pp. 93-94

Author(s):

S. Lee ◽

Y. Kim ◽

M. Lee ◽

H. Ko ◽

S. Oh ◽

...

Keyword(s):

Multicentre Study ◽

Pregnant Women ◽

Scoring Systems ◽

Ovarian Mass

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A Multicentre Study to Investigate the Prevalence of Abnormal Carbohydrate Metabolism in Chinese Pregnant Women

Journal of Obstetrics and Gynaecology Research ◽

10.1111/j.1447-0756.1996.tb00997.x ◽

1996 ◽

Vol 22 (4) ◽

pp. 401-407 ◽

Cited By ~ 5

Author(s):

C. P. Lee ◽

Z. Q. Wang ◽

S. J. Duthie ◽

H. K. Ma ◽

J. Z. Zhang ◽

...

Keyword(s):

Multicentre Study ◽

Pregnant Women ◽

Carbohydrate Metabolism

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Ultrasound Measurements of Fetal Thyroid: Reference Ranges from a Cohort of Low-Risk Pregnant Women

BioMed Research International ◽

10.1155/2019/9524378 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8

Author(s):

R. M. Barbosa ◽

K. C. Andrade ◽

C. Silveira ◽

C. M. Almeida ◽

R. T. Souza ◽

...

Keyword(s):

Multicentre Study ◽

Pregnant Women ◽

Reference Values ◽

Low Risk ◽

Fetal Life ◽

Reference Ranges ◽

Reference Curve ◽

Ultrasound Measurements ◽

Fetal Thyroid ◽

Prospective Longitudinal

Background. Adequate thyroid function is essential for normal growth and development of the fetus. Sonographic recognition of alterations in fetal thyroid dimensions may be the first sign of thyroid dysfunction, permitting early diagnosis and intervention. The main goal of this study was to build curves with reference values for ultrasound measurements of the fetal thyroid from 14 to 40 weeks of gestation. Methods. This is a prospective longitudinal study of 90 Brazilian pregnant women, complementary to a cohort multicentre study named “WHO multicentre study for the development of growth standards from fetal life to childhood: the fetal component.” Pregnant women without any pre-existing conditions that might affect fetal growth received antenatal care from the first trimester until childbirth, undergoing serial ultrasound evaluations of the fetus, including the thyroid. Longitudinal, anteroposterior, and transverse diameters of both thyroid lobes were measured in the fetus. Fetal thyroid lobe volume was also estimated. By quantile regression analysis, reference curves of measurements were fitted according to the gestational age. Results. A reference standard of thyroid growth was defined during pregnancy by fitting curves of its measurements. Reference values for the 10th, 50th, and 90th centiles of fetal thyroid measurements (longitudinal, anteroposterior, transverse diameters, and lobe volume) were defined, from 14 to 40 weeks of gestation. Conclusion. We provided a reference curve of optimal thyroid development in a low-risk population that can be used as a standard of comparison to diagnose deviations from the norm. In addition, we demonstrated an alternative and simplified method for early recognition of thyroid morphological alterations by an individualized technique to evaluate the thyroid lobes.

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