A Multicentre Study to Investigate the Prevalence of Abnormal Carbohydrate Metabolism in Chinese Pregnant Women

1996 ◽  
Vol 22 (4) ◽  
pp. 401-407 ◽  
Author(s):  
C. P. Lee ◽  
Z. Q. Wang ◽  
S. J. Duthie ◽  
H. K. Ma ◽  
J. Z. Zhang ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Pregnant Women ◽  
Carbohydrate Metabolism

scholarly journals The Value of Non-Invasive Prenatal Testing in the Diagnosis of Birth Defects: Insights from a Large Multicentre Study in Southern China

2021 ◽  
Author(s):  
Meiying Cai ◽  
Na Lin ◽  
Xuemei Chen ◽  
Ying Li ◽  
Min Lin ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Pregnant Women ◽  
Chromosomal Abnormalities ◽  
Southern China ◽  
Prenatal Testing ◽  
Copy Number Variations ◽  
Trisomy 13 ◽  
Detection Rates ◽  
Non Invasive ◽  
Large Multicentre Study

Abstract Non-invasive prenatal testing (NIPT) is a fast, safe, and non-disruptive diagnostic method. At present, few studies have evaluated the screening efficiency of NIPT positive predictive value (PPV) in study subjects. Here, the results of NIPT in pregnant women were retrospectively analysed, and the detection rate, PPV and follow-up data were evaluated to determine its clinical value. A large multicentre study was conducted involving 52,855 pregnant women who received NIPT. Based on gestational age, amniotic fluid or umbilical cord blood were extracted for simultaneous karyotype and chromosome microarray analysis (CMA) in NIPT-positive patients. Among the 52,855 cases, 754 were NIPT-positive, with a positivity rate of 1.4%. Karyotype analysis and/or CMA confirmed 323 cases of chromosomal abnormalities, with a PPV of 45.1%. PPV of Trisomy 21 (T21), Trisomy 18 (T18), Trisomy 13 (T13), sex chromosomal aneuploidies (SCA) and copy number variations (CNV) were 78.9%, 35.3%, 22.2%, 36.9% and 32.9%, respectively. The PPV of T21, T18, and T13 increased with age whereas, the PPV of SCA and CNVs had little correlation with age. The PPV was significantly high in patients with advanced age along with an abnormal ultrasound.NIPT had a high PPV for T21, and a low PPV for T13 and T18, while screening for SCA and CNVs showed clinical significance. However, in case of NIPT screening for SCA and CNVs, simultaneous karyotype and CMA should be performed to increase the detection rates. Interventional prenatal diagnosis is still required in NIPT-positive cases to avoid false positives or unnecessary termination of pregnancy.

Comparison of HbA1c and glycated albumin as a control marker for newborn complications in diabetic women in a multicentre study in Japan (Japan glycated albumin study group: study 2)

2018 ◽  
Vol 55 (6) ◽  
pp. 639-646 ◽  
Author(s):  
Ikki Shimizu ◽  
Yuji Hiramatsu ◽  
Yasue Omori ◽  
Masao Nakabayashi ◽  
Keyword(s):  
Multicentre Study ◽  
Pregnant Women ◽  
Plasma Glucose ◽  
Glycated Albumin ◽  
Reference Interval ◽  
Glycated Haemoglobin ◽  
Respiratory Disorder ◽  
Neonatal Complications

Background To clarify the relationship between glycated haemoglobin and glycated albumin concentrations during pregnancy with neonatal outcomes, a multicentre study was conducted by the Japanese Society of Diabetes and Pregnancy. Methods A total of 136 patients (type 1: n = 47, type 2: n = 89) who enrolled in the study were diagnosed based on the Japanese Diabetes Society diagnostic criteria for diabetes mellitus. Thresholds for glycated haemoglobin and glycated albumin were set at 5.8% and 15.8%, respectively, as the upper limits of the reference interval in pregnant women. Result Random plasma glucose decreased linearly, and reached the reference interval at 40 weeks. Glycated albumin concentrations also decreased in the same manner. But glycated haemoglobin concentrations were out of the reference interval during the study. The frequency of the neonatal complications did not show significant differences between the glycated haemoglobin ⩾5.8% group and the glycated haemoglobin <5.8% group. On the other hand, the frequency of neonatal complications showed higher tendency of neonatal complications in the incidence of polycythaemia ( P = 0.094) and heavy-for-date ( P = 0.071) in the glycated albumin ⩾15.8% group compared with the glycated albumin <15.8 group. The respiratory disorder in type 1 diabetes was significantly higher than type 2 diabetes. Conclusions For the treatment of pregnant women with diabetes, glycated albumin would be a better marker than glycated haemoglobin. However, glycated albumin is also affected by obesity and albumin, and it is desirable to make a comprehensive judgment with glycated haemoglobin, random plasma glucose and other glycaemic index.

scholarly journals Quality of Life, Social Support, Acceptance of Illness, and Self-Efficacy among Pregnant Women with Hyperglycemia

2019 ◽  
Vol 16 (20) ◽  
pp. 3941 ◽  
Author(s):  
Iwanowicz-Palus ◽  
Zarajczyk ◽  
Pięta ◽  
Bień
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Pregnant Women ◽  
Carbohydrate Metabolism ◽  
Self Efficacy ◽  
World Health ◽  
World Health Organization Quality ◽  
The Mean ◽  
Acceptance Of Illness

Carbohydrate metabolism disorders resulting in hyperglycemia are among the most common metabolic complications of pregnancy. According to 2017 data from the International Diabetes Federation (IDF), 16.2% of pregnancies are complicated with hyperglycemia, of which gestational diabetes mellitus (GDM) accounts for 86.4% of cases. Carbohydrate metabolism disorders developing during pregnancy require the patient to change her lifestyle or, in some cases, to undergo pharmaceutical treatment, which may affect various aspects of the patient’s life, including her perceived quality of life (QoL). The purpose of the present study was to evaluate levels of QoL, social support, acceptance of illness, and self-efficacy among pregnant patients with hyperglycemia. The study was performed between July 2016 and September 2017 in a group of hyperglycemic pregnant women. The following instruments were used: the World Health Organization Quality of Life—BREF (WHOQOL-BREF), the Berlin Social Support Scales (BSSS), the Acceptance of Illness Scale (AIS), the Generalized Self-Efficacy Scale (GSES) and a standardized interview questionnaire. Participants rated their overall QoL (3.64 points) higher than their overall perceived health (3.43). In terms of social support, the highest scores were obtained in terms of actually received support (3.53) and perceived available instrumental support (3.52), while the lowest in terms of support seeking (2.99) and the need for support (2.95). The mean acceptance of illness score among the hyperglycemic pregnant women that were studied was 31.37, and the mean generalized self-efficacy score was 31.58. Participants’ reported QoL in the various WHOQOL-BREF domains was associated with specific social support scales, acceptance of illness, and generalized self-efficacy.

HCV–HIV coinfected pregnant women: data from a multicentre study in Italy

Infection ◽  
2015 ◽  
Vol 44 (2) ◽  
pp. 235-242 ◽  
Author(s):  
S. Baroncelli ◽  
M. F. Pirillo ◽  
R. Amici ◽  
E. Tamburrini ◽  
O. Genovese ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Pregnant Women

scholarly journals Potentialities of modern glucose monitoring devices during pregnancy

2020 ◽  
Vol 4 (6) ◽  
pp. 352-357
Author(s):  
F.O. Ushanova ◽  
◽  
T.Yu. Demidova ◽  
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Carbohydrate Metabolism ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Nocturnal Hypoglycemia ◽  
Glucose Levels ◽  
Monitoring Technologies ◽  
Diabetes Gestational ◽  
Monitoring Devices

Currently, the management of pregnant women with carbohydrate metabolism disorders is challenging due to the high risk of unfavorable events both for the mother and the child even in insignificant deviations from the target value. In addition to the conventional methods of self-monitoring, continuous glucose monitoring (CGM) is an important tool to control diabetes. CGM in pregnant women provides the detailed information on the type and trends of the changes in blood glucose levels and the fluctuations of glucose levels and also identifies the episodes of latent nocturnal hypoglycemia and postprandial hyperglycemia. The analysis of CGM data allows for correcting insulin therapy, taking a decision on its initiation, and modifying diet and exercise plan. Multiple studies demonstrate the efficacy of CGM in terms of compensating manifest diabetes. As to gestational diabetes, the eligibility of modern glucose monitoring technologies for the prevention of various complications is still controversial. Further studies on the potential use of these devices in gestational diabetes could provide a basis for increasing their application in routine clinical practice. This will improve the management of pregnant women with carbohydrate metabolism disorders.KEYWORDS: diabetes, gestational diabetes, continuous glucose monitoring, flash monitoring, pregnancy, macrosomia, self-monitoring.FOR CITATION: Ushanova F.O., Demidova T.Yu. Potentialities of modern glucose monitoring devices during pregnancy. Russian Medical Inquiry. 2020;4(6):352–357. DOI: 10.32364/2587-6821-2020-4-6-352-357.

The endocrine system and vomiting in pregnant women

1926 ◽  
Vol 22 (11) ◽  
pp. 1296-1296
Keyword(s):  
Mammary Gland ◽  
Pituitary Gland ◽  
Pregnant Women ◽  
Corpus Luteum ◽  
Carbohydrate Metabolism ◽  
Endocrine System ◽  
Posterior Pituitary ◽  
Posterior Pituitary Lobe

The author notes in hyperemesis a disorder of carbohydrate metabolism and depletion of the liver in glycogen, which, in his opinion, is due to increased secretion of the posterior pituitary lobe. Normally, this secretion is regulated by hormones of the mammary gland, placenta, and corpus luteum. If these hormones are insufficient, hyperfunction of the pituitary gland with its consequences occurs.

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