Magnetic Nanoparticles as Contrast Agents for Magnetic Resonance Imaging

2012 ◽  
Vol 82 (3) ◽  
pp. 257-268 ◽  
Author(s):  
R. S. Chaughule ◽  
S. Purushotham ◽  
R. V. Ramanujan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging

Magnetic iron oxide nanoparticles asT1contrast agents for magnetic resonance imaging

2018 ◽  
Vol 6 (6) ◽  
pp. 1280-1290 ◽  
Author(s):  
Y. Bao ◽  
J. A. Sherwood ◽  
Z. Sun
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Synthesis Parameters

This review discusses several aspects regarding ultrasmall magnetic nanoparticles asT1contrast agents, including synthesis, parameters affectingT1, and applications.

scholarly journals Magnetic Nanoparticles for Early Detection of Cancer by Magnetic Resonance Imaging

MRS Bulletin ◽  
2009 ◽  
Vol 34 (6) ◽  
pp. 441-448 ◽  
Author(s):  
Wenbin Lin ◽  
Taeghwan Hyeon ◽  
Gregory M. Lanza ◽  
Miqin Zhang ◽  
Thomas J. Meade
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Early Detection ◽  
Contrast Agents ◽  
Contrast Enhancement ◽  
Negative Contrast ◽  
Mri Contrast Agents ◽  
Ferrite Nanoparticles ◽  
Resonance Imaging

AbstractThis article provides a brief overview of recent progress in the synthesis and functionalization of magnetic nanoparticles and their applications in the early detection of malignant tumors by magnetic resonance imaging (MRI). The intrinsic low sensitivity of MRI necessitates the use of large quantities of exogenous contrast agents in many imaging studies. Magnetic nanoparticles have recently emerged as highly efficient MRI contrast agents because these nanometer-scale materials can carry high payloads while maintaining the ability to move through physiological systems. Superparamagnetic ferrite nanoparticles (such as iron oxide) provide excellent negative contrast enhancement. Recent refinement of synthetic methodologies has led to ferrite nanoparticles with narrow size distributions and high crystallinity. Target-specific tumor imaging becomes possible through functionalization of ferrite nanoparticles with targeting agents to allow for site-specific accumulation. Nanoparticulate contrast agents capable of positive contrast enhancement have recently been developed in order to overcome the drawbacks of negative contrast enhancement afforded by ferrite nanoparticles. These newly developed magnetic nanoparticles have the potential to enable physicians to diagnose cancer at the earliest stage possible and thus can have an enormous impact on more effective cancer treatment.

Biofunctional magnetic nanoparticles as contrast agents for magnetic resonance imaging of pancreas cancer

2009 ◽  
Vol 167 (1-2) ◽  
pp. 27-34 ◽  
Author(s):  
Mingming Huang ◽  
Zhongwei Qiao ◽  
Fei Miao ◽  
Nengqin Jia ◽  
Hebai Shen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Pancreas Cancer ◽  
Resonance Imaging

Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using T1-enhanced contrast

2018 ◽  
Vol 6 (10) ◽  
pp. 1470-1478 ◽  
Author(s):  
Y. B. Lv ◽  
P. Chandrasekharan ◽  
Y. Li ◽  
X. L. Liu ◽  
J. P. Avila ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Relaxation Times ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

Monodispersed 4 nm Gd-doped iron oxide nanoparticles (GdIONPs) were fabricated, and were as T1-weighted contrast agents to confirm the feasibility of non-invasively quantify and monitor IONPs in vivo based on MRI longitudinal relaxation times.

Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Tobacco Mosaic Virus ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Physiological Conditions

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

scholarly journals Magnetic resonance thermometry using a GdIII-based contrast agent

2021 ◽  
Vol 57 (14) ◽  
pp. 1770-1773
Author(s):  
S. A. Amali S. Subasinghe ◽  
Jonathan Romero ◽  
Cassandra L. Ward ◽  
Matthew D. Bailey ◽  
Donna R. Zehner ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Magnetic Resonance Thermometry

The complexes described here serve as contrast agents for magnetic resonance imaging thermometry.

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