The cultural history of Newfoundland and Labrador is linked with the sea. The European occupation of this subarctic region was dependent on the abundance of Atlantic cod and other marine resources, such as seals, walrus, and whales. Precontact indigenous hunter gatherers of the region also relied heavily on marine ecology for their livelihood; yet, at various times in the region’s significant history, dynamic environmental and social conditions acted to change subsistence economies, cultures, and the course of its occupation. In this chapter, we examine archaeological, historical, and paleoecological evidence to assess the relative roles that environmental and social processes played in these critical transformations.