scholarly journals Painful Diabetic Peripheral Neuropathy Study of Chinese Outpatients (PDNSCOPE): A Multicentre Cross-Sectional Registry Study of Clinical Characteristics and Treatment in Mainland China

2021 ◽  
Author(s):  
Yuanjin Zhang ◽  
Shaowei Zhang ◽  
Liya Pan ◽  
Baojun Wang ◽  
Yuanlin Sun ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Clinical Characteristics ◽  
Mainland China ◽  
Registry Study ◽  
Cross Sectional ◽  
Painful Diabetic Peripheral Neuropathy

scholarly journals Painful Diabetic Peripheral Neuropathy Study of Chinese OutPatiEnts (PDN-SCOPE): protocol for a multicentre cross-sectional registry study of clinical characteristics and treatment in China

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e025722
Author(s):  
Yuanjin Zhang ◽  
Nan Li ◽  
Yiming Zhao ◽  
Dongsheng Fan
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Clinical Characteristics ◽  
Medical Science ◽  
Visual Analogue Scale Pain ◽  
Anxiety And Depression ◽  
Registry Study ◽  
Cross Sectional ◽  
Treatment Practices ◽  
Painful Diabetic Peripheral Neuropathy

IntroductionPainful diabetic peripheral neuropathy (PDN) is a growing public health problem in China. Despite recent progress in treatment, there has been no nationwide study evaluating current medical practices and compliance with treatment guidelines. The primary aims of this study are to investigate the clinical characteristics and treatment practices for PDN and associated anxiety and depression in China.Methods and analysisPainful Diabetic Peripheral Neuropathy Study of Chinese OutPatiEnts is a cross-sectional, multicentre registry study with a target sample size of approximately 1500 people experiencing PDN. People with PDN will be treated according to current guidelines and local practices. The demographics, medical histories, Visual Analogue Scale pain scores, Patient Health Questionnaire-9 results, Generalised Anxiety Disorder-7 scores and therapies will be recorded to evaluate clinical characteristics of PDN and current treatment practices for pain, anxiety and depression.Ethics and disseminationEthical approval has been obtained from the Peking University Third Hospital Medical Science Research Ethics Committee (2018–182).The results of this study will be disseminated through peer-reviewed publications and scientific presentations.Trial registration numberNCT03520608

Mechanical Allodynia Predicts Better Outcome of Surgical Decompression for Painful Diabetic Peripheral Neuropathy

2018 ◽  
Vol 34 (06) ◽  
pp. 446-454 ◽  
Author(s):  
Chenlong Liao ◽  
D. Nickerson ◽  
Massimiliano Visocchi ◽  
Min Yang ◽  
Pengfei Liu ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Surgical Outcome ◽  
Diabetic Peripheral Neuropathy ◽  
Mechanical Allodynia ◽  
Depression Scale ◽  
Pain Reduction ◽  
Control Group ◽  
Cross Sectional ◽  
Painful Diabetic Peripheral Neuropathy ◽  
High Resolution Ultrasonography

Background To determine the role of mechanical allodynia (MA) in predicting good surgical outcome for painful diabetic peripheral neuropathy (DPN). Materials and Methods Data of 192 patients with painful DPN were collected in this study, with 148 surgical patients and 44 patients in the control group. Both groups were further divided into subgroups based on the presence of MA on admission. Clinical evaluations including the visual analog scale (VAS), the Hospital Anxiety and Depression Scale (HADS), nerve conduction velocity (NCV), and high-resolution ultrasonography (cross-sectional area, CSA) were performed preoperatively and postoperatively. Results The levels of VAS and HADS and the results of NCV and CSA were improved in the surgical group (p < 0.05). In the surgical subgroups, pain reduction, psychiatric amelioration, improvement in NCVs, and the restoration of the CSA were observed in patients with signs of MA (p < 0.05), whereas only pain reduction, psychiatric amelioration, and restoration of the CSA were noted in patients without signs of MA (p > 0.05). Furthermore, better pain reduction was achieved in patients with MA when compared with those without MA (p < 0.05). Conclusions MA is proved to be a reliable predictor of good surgical outcome for painful DPN.

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