Pharmacokinetics of ABT-122, a TNF-α- and IL-17A-Targeted Dual-Variable Domain Immunoglobulin, in Healthy Subjects and Patients with Rheumatoid Arthritis: Results from Three Phase I Trials

2017 ◽  
Vol 57 (5) ◽  
pp. 613-623 ◽  
Author(s):  
Amit Khatri ◽  
Sandra Goss ◽  
Ping Jiang ◽  
Heikki Mansikka ◽  
Ahmed A. Othman
Keyword(s):  
Rheumatoid Arthritis ◽  
Phase I ◽  
Healthy Subjects ◽  
Variable Domain ◽  
Phase I Trials ◽  
Dual Variable ◽  
Three Phase ◽  
Tnf Α

scholarly journals 176 POSTER Outcome of three Phase I trials of the marine compound ES-285 (3 hour infusion) in patients with refractory solid tumors

2008 ◽  
Vol 6 (12) ◽  
pp. 56 ◽  
Author(s):  
P. Schöffski ◽  
V. Grünwald ◽  
G. Giaccone ◽  
R. Salazar ◽  
M. Majem ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Phase I Trials ◽  
Three Phase ◽  
Marine Compound

Pharmacokinetics and Tolerability of a Dual Variable Domain Immunoglobulin ABT-981 Against IL-1α and IL-1β in Healthy Subjects and Patients With Osteoarthritis of the Knee

2016 ◽  
Vol 56 (12) ◽  
pp. 1582-1590 ◽  
Author(s):  
Matthew P. Kosloski ◽  
Sandra Goss ◽  
Susanne X. Wang ◽  
Jia Liu ◽  
Ralf Loebbert ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Variable Domain ◽  
Osteoarthritis Of The Knee ◽  
Dual Variable

FRI0188 Safety, Tolerability, and Pharmacodynamics of ABT-122, A Dual TNF- and IL-17–Targeted Dual Variable Domain (DVD)-IG™ in Patients with Rheumatoid Arthritis

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 498.1-498 ◽  
Author(s):  
R.M. Fleischmann ◽  
F. Wagner ◽  
A.J. Kivitz ◽  
H.T. Mansikka ◽  
N. Khan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Variable Domain ◽  
Dual Variable

scholarly journals Safety, Tolerability, and Pharmacodynamics of ABT-122, a Tumor Necrosis Factor- and Interleukin-17-Targeted Dual Variable Domain Immunoglobulin, in Patients With Rheumatoid Arthritis

2017 ◽  
Vol 69 (12) ◽  
pp. 2283-2291 ◽  
Author(s):  
Roy M. Fleischmann ◽  
Frank Wagner ◽  
Alan J. Kivitz ◽  
Heikki T. Mansikka ◽  
Nasser Khan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Variable Domain ◽  
Interleukin 17 ◽  
Dual Variable ◽  
Necrosis Factor
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