scholarly journals Summary Safety Review: sinus bradycardia with remdesivir

2021 ◽  
Vol 1877 (1) ◽  
pp. 2-2
Keyword(s):  
Sinus Bradycardia ◽  
Safety Review

FDA Launches Safety Review of TNF Blockers

2008 ◽  
Vol 38 (14) ◽  
pp. 5
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Safety Review ◽  
Tnf Blockers

scholarly journals Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage

2021 ◽  
Author(s):  
Athanasios Chalkias ◽  
Ioannis Pantazopoulos ◽  
Nikolaos Papagiannakis ◽  
Anargyros Skoulakis ◽  
Eleni Laou ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Sinus Bradycardia ◽  
Poor Outcome

Comparative safety review of recommended, first-line single-tablet regimens in patients with HIV

2021 ◽  
Author(s):  
Arturo Ciccullo ◽  
Gianmaria Baldin ◽  
Cristina Putaggio ◽  
Simona Di Giambenedetto ◽  
Alberto Borghetti
Keyword(s):  
First Line ◽  
Safety Review ◽  
Comparative Safety

OP139 Attaining Universal Electrocardiographic Diagnosis Coverage Through Telemedicine

2020 ◽  
Vol 36 (S1) ◽  
pp. 1-1
Author(s):  
Pedro Galvan ◽  
José Ortellado ◽  
Ronald Rivas ◽  
Juan Portillo ◽  
Julio Mazzoleni ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Disease Prevention ◽  
Prevention Program ◽  
Sinus Bradycardia ◽  
Universal Coverage ◽  
Left Ventricular ◽  
Cardiovascular Disease Prevention ◽  
Public Hospitals ◽  
Cross Sectional Survey ◽  
Health Technologies

IntroductionInnovative health technologies, like telemedicine, offer advantageous telediagnostic apps that can improve the health care of populations in remote regions. However, evidence on how these developments can enhance universal coverage for electrocardiographic (ECG) diagnosis to support a cardiovascular disease prevention program is limited. The utility of telemedicine for attaining universal coverage for ECG diagnosis according to the national cardiovascular disease prevention program in Paraguay was investigated.MethodsThis cross-sectional survey included adults (aged 19 to 80 years) and children (aged 1 to 18 years) with a medical prescription. The study was carried out by the Telemedicine Unit to evaluate the utility of a telemedicine net for a countrywide detection and prevention program for cardiovascular disease. The results obtained by the tele-ECG net, which was implemented in sixty public hospitals countrywide, were analyzed and used to verify adherence to the cardiovascular prevention program.ResultsBetween 2014 and 2019, 331,418 remote ECG diagnoses were performed. Of these, eighty-two percent (n = 270,539) were in adults and eighteen percent (n = 60,879) were in children. Among the adult diagnoses, the majority (52%) were pathological and included sinus bradycardia (13%), right bundle branch block (6%), left ventricular hypertrophy (5%), and ventricle repolarization disorder (5%). Among the children, only twenty percent of diagnoses pathological and included sinus bradycardia (11%) and sinus tachycardia (4%). The mean rate of adherence to the prevention program was 38.2 per 1,000 diagnoses performed.ConclusionsThe results showed that telemedicine can significantly enhance coverage for universal ECG diagnosis to support cardiovascular disease prevention and health programs. However, before carrying out the systematic implementation of such a program contextualization using the regional epidemiological profile must be performed.

Electrical stimulation mapping of the pulmonary artery in swine: impact on pulmonary artery denervation procedure for pulmonary hypertension

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
H.I Condori Leandro ◽  
N Goncharova ◽  
A Vakhrushev ◽  
L Korobchenko ◽  
E Andreeva ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
High Frequency ◽  
Sinus Bradycardia ◽  
Final Analysis ◽  
High Frequency Stimulation ◽  
Funding Source ◽  
Recurrent Nerve ◽  
Autopsy Study ◽  
Frequency Stimulation ◽  
Laryngeal Recurrent Nerve

Abstract Introduction Pulmonary artery denervation (PAD) has been recently shown to decrease pulmonary artery (PA) pressure. However, there is a lack of data related to target sites for ablation. Purpose To determine the optimal PA ablation sites based on response to high-frequency stimulation mapping and anatomical areas where radiofrequency ablation (RFA) should be avoided due to the risk of severe collateral damage. Methods A total of 17 Landrace swines were included into the study. PA angiography, hemodynamic measurements by right heart-sided catheterization and electrophysiological mapping (EM) using low (cycle length 330 ms) and high-frequency (33Hz) stimulation (HFS). Stimulation was performed at PA bifurcation and proximal parts of the main PA branches with a 5-mm distance between points; catheter manipulation was performed under fluoroscopic guidance in multiple projections. Points with evoked reactions were tagged on a 3-dimentional PA model in each case. In order to confirm reproducibility of reactions, HFS was performed at least twice at each point with a response. PA models obtained from all animals were combined in one for the final analysis. RFA using an open-irrigated catheter (40 Watts; 40 s; irrigation 30 ml/min) were performed at sites with evoked reactions. Repeated HFS was performed at ablation sites. After the procedure all animals were euthanized and underwent an autopsy study. Results Low-frequency stimulation (LFS) allowed to define areas of ventricular capture (VC) where HFS was avoided due to ventricular fibrillation induction risk. During HFS the following evoked responses were documented: sinus bradycardia, sinus rhythm (SR) acceleration, phrenic nerve capture (PNC), and laryngeal recurrent nerve capture. HFS captured left and right phrenic nerves in all animals at PA trunk, and its course was tagged (Figure 1). Laryngeal recurrent nerve capture was found in 4 (23%) of animals. Atrial capture was found in all cases while LFS at the anterior aspects of both PAs even at low output, and this precluded evaluation of neural autonomic reactions in these areas. Evoked bradycardia and SR acceleration were both found during HFS in 10 (59%) of cases each. Following RFA application evoked reactions were non-reproducible in all cases. RFA was applied in areas where no PNC or VC points were observed. An autopsy study confirmed the presence of RF-induced lesions of the PA wall. Conclusions There are two important findings of our study. First, stimulation-guided PA mapping is feasible and reveals several specific responses to HFS. Ablation at points with responses leads to non-reproducibility of the evoked reactions, confirming that transcatheter RFA may be an adequate approach for PA denervation. Second, previously proposed circular PA ablation might be associated with phrenic and laryngeal recurrent nerve damage. Stimulation-guided PA denervation can be proposed as a safer procedure, and should be evaluated in clinical settings. Figure 1. PA schematic representation Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Russian Foundation for Basic Research

scholarly journals Alcohol-Induced Sinus Bradycardia and Hypotension in Patients with Syncope.

1992 ◽  
Vol 33 (6) ◽  
pp. 875-879 ◽  
Author(s):  
Masato TSUTSUI ◽  
Takeyuki MATSUGUCHI ◽  
Hiroyuki TSUTSUI ◽  
Tetsuhiko YOSHIDA ◽  
Shingo YOSHIHARA ◽  
...  
Keyword(s):  
Sinus Bradycardia
Sign in / Sign up

Export Citation Format

Share Document