Ingenol-mebutate

doi:10.1007/s40278-021-07034-y

Ingenol Mebutate Gel

10.32388/5t88py ◽

2020 ◽

Author(s):

Keyword(s):

Ingenol Mebutate

An Open-Label Exploratory Study Evaluating the Efficacy and Safety of Ingenol Mebutate Gel 0.05% for the Treatment of Verruca Vulgaris

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.1.supp.137 ◽

2017 ◽

Vol 1 ◽

pp. s138

Author(s):

Neal D Bhatia

Keyword(s):

Exploratory Study ◽

Efficacy And Safety ◽

Ingenol Mebutate ◽

Open Label ◽

Verruca Vulgaris

Abstract Not Available

Human medicines European public assessment report (EPAR): Picato, ingenol mebutate, Keratosis, Actinic, Date of authorisation: 15/11/2012, Revision: 8, Status: Authorised

Case Medical Research ◽

10.31525/cmr-128cc28 ◽

2019 ◽

Author(s):

Keyword(s):

Ingenol Mebutate ◽

Assessment Report ◽

European Public ◽

European Public Assessment Report

Fluorouracil/imiquimod/ingenol mebutate

Reactions Weekly ◽

10.1007/s40278-021-99096-2 ◽

2021 ◽

Vol 1864 (1) ◽

pp. 166-166

Keyword(s):

Ingenol Mebutate

Ingol and Ingenol-Type Diterpenes from Euphorbia trigona Miller with Keratinocyte Inhibitory Activity

Plants ◽

10.3390/plants10061206 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1206

Author(s):

Reham Hammadi ◽

Norbert Kúsz ◽

Csilla Zsuzsanna Dávid ◽

Zoltán Behány ◽

László Papp ◽

...

Keyword(s):

Liquid Chromatography ◽

Cytotoxic Activity ◽

Inhibitory Activity ◽

High Performance ◽

Skin Condition ◽

Positive Control ◽

Active Species ◽

The European Union ◽

Ingenol Mebutate

Ingenol mebutate, isolated from Euphorbia peplus, is an ingenane-type diterpenoid, primarily used for the topical treatment of actinic keratosis, a premalignant skin condition. The aim of our work was to investigate other Euphorbia species to find structurally similar diterpenes that can be used as alternatives to ingenol mebutate. Pharmacological investigation of Euphorbia candelabrum, Euphorbia cotinifolia, Euphorbia ramipressa, and Euphorbia trigona revealed the potent keratinocyte (HPV-Ker cell line) inhibitory activity of these spurge species. From the methanolic extract of the aerial parts of Euphorbia trigona Miller, the most active species, five ingol (1–5) and four ingenane-type diterpenoids (6–9) were isolated by various chromatographic separation techniques, including open column chromatography, vacuum liquid chromatography, thin-layer chromatography, and high-performance liquid chromatography. The structures of the compounds were determined by NMR spectroscopic analysis and by comparison of the assignations with the literature data. The cytotoxic activity of the compounds against keratinocytes was tested in vitro by using ingenol mebutate as a positive control. Among the isolated compounds, two ingenane derivatives (6 and 7) exhibited remarkably stronger cytotoxic activity (IC50 values 0.39 μM and 0.32 μM, respectively) on keratinocytes than ingenol mebutate (IC50 value 0.84 μM). These compounds could serve as starting materials for further investigations to find alternatives to Picato® (with active substance ingenol mebutate), which was withdrawn from marketing authorization in the European Union.

Ivacaftor, vismodegib, and ingenol mebutate

Journal of the American Pharmacists Association ◽

10.1331/japha.2012.12517 ◽

2012 ◽

Vol 52 (3) ◽

pp. 418-422 ◽

Cited By ~ 1

Author(s):

Daniel A. Hussar ◽

Samuel P. Eckel

Keyword(s):

Ingenol Mebutate

Multicenter, randomized, parallel-group, double-blind, vehicle-controlled study to evaluate the efficacy and safety of PEP005 (ingenol mebutate) gel, 0.05% in patients with actinic keratoses on nonhead locations

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2009.11.043 ◽

2010 ◽

Vol 62 (3) ◽

pp. AB2 ◽

Cited By ~ 1

Keyword(s):

Controlled Study ◽

Efficacy And Safety ◽

Ingenol Mebutate ◽

Double Blind ◽

Actinic Keratoses ◽

Parallel Group