Quantitative Assessment of CYP2C9 Genetic Polymorphisms Effect on the Oral Clearance of S-Warfarin in Healthy Subjects

2016 ◽  
Vol 21 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Chanan Shaul ◽  
Simcha Blotnick ◽  
Mordechai Muszkat ◽  
Meir Bialer ◽  
Yoseph Caraco
Keyword(s):  
Genetic Polymorphisms ◽  
Healthy Subjects ◽  
Quantitative Assessment ◽  
Oral Clearance

Validation and clinical application of dried blood spot assay for quantitative assessment of edoxaban in healthy adults

Bioanalysis ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 393-407
Author(s):  
Ling He ◽  
Roohi Gajee ◽  
Raj Mangaraj ◽  
Michael P Waldron ◽  
Karen S Brown
Keyword(s):  
Healthy Subjects ◽  
Quantitative Assessment ◽  
Dried Blood Spot ◽  
Plasma Samples ◽  
Open Label ◽  
Finger Prick ◽  
Incurred Sample Reanalysis ◽  
Alternative Methodology ◽  
Blood Spot ◽  
Sampling Approach

Aim: Dried blood spot (DBS) is a sampling approach that offers several advantages over plasma and whole blood (WB) sampling, but several factors, such as hematocrit and temperature, can adversely affect quantitation. Methodology & results: In an open-label, three-way crossover study in healthy subjects, we explored the correlation between DBS, WB and plasma samples, and between DBS samples from finger-prick and venipuncture blood for measuring edoxaban and its metabolite M-4 using LC–MS/MS. The methods were validated comprehensively. The incurred sample reanalysis experiments demonstrated quantitation reproducibility in all three matrices. Overall, there was a good correlation (near perfect concordance for edoxaban) among plasma, WB and DBS measurements. M-4 concentrations in DBS and WB were lower than in plasma. Conclusion: These results indicate using DBS may be used as an alternative methodology to measure edoxaban pharmacokinetics.

scholarly journals The association between the serotonin and dopamine neurotransmitters and personality traits

2016 ◽  
Vol 25 (2) ◽  
pp. 109-112 ◽  
Author(s):  
G. Delvecchio ◽  
M. Bellani ◽  
A. C. Altamura ◽  
P. Brambilla
Keyword(s):  
Personality Traits ◽  
Psychiatric Disorders ◽  
Candidate Genes ◽  
Genetic Polymorphisms ◽  
Complex Traits ◽  
Healthy Subjects ◽  
Mental Illnesses ◽  
Biological Mechanisms ◽  
Normal Personality ◽  
The Impact

Evidence from previous studies has reported that complex traits, including psychiatric disorders, are moderately to highly heritable. Moreover, it has also been shown that specific personality traits may increase the risk to develop mental illnesses. Therefore the focus of the research shifted towards the identification of the biological mechanisms underpinning these traits by exploring the effects of a constellation of genetic polymorphisms in healthy subjects. Indeed, studying the effect of genetic variants in normal personality provides a unique means for identifying candidate genes which may increase the risk for psychiatric disorders. In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors. The main aims are: (a) to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship; and (b) to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits.

Influences of ABC transporter and CYP3A4/5 genetic polymorphisms on the pharmacokinetics of lenvatinib in Chinese healthy subjects

2020 ◽  
Vol 76 (8) ◽  
pp. 1125-1133
Author(s):  
Jiaming Li ◽  
Xiaoqian Wang ◽  
Chen Ning ◽  
Zhaoyu Wang ◽  
Yao Wang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Abc Transporter ◽  
Healthy Subjects

scholarly journals Effects of ABCB1 , UGT1A1 , and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects

2020 ◽  
Author(s):  
Lu‐Ning Sun ◽  
Guo‐Xian Sun ◽  
Yu‐Qing Yang ◽  
Ye Shen ◽  
Feng‐Ru Huang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Healthy Subjects

Determination of NLRP3 (rs4612666) and IL-1B (rs1143634) genetic polymorphisms in periodontally diseased and healthy subjects

2016 ◽  
Vol 65 ◽  
pp. 44-51 ◽  
Author(s):  
Diana M. Isaza-Guzmán ◽  
Melissa Hernández-Viana ◽  
Diego M. Bonilla-León ◽  
María C. Hurtado-Cadavid ◽  
Sergio I. Tobón-Arroyave
Keyword(s):  
Genetic Polymorphisms ◽  
Healthy Subjects

scholarly journals Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of risperidone in healthy subjects with CYP2D6 * 10 /* 10

2011 ◽  
Vol 164 (2b) ◽  
pp. 433-443 ◽  
Author(s):  
Hee‐Doo Yoo ◽  
Sang‐No Lee ◽  
Hyun‐Ah Kang ◽  
Hea‐Young Cho ◽  
Il‐Kwon Lee ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Healthy Subjects

Objective Quantitative Assessment of Movement Disorders Through Analysis of Static Handwritten Characters

2015 ◽  
Author(s):  
Naiqian Zhi ◽  
Beverly K. Jaeger ◽  
Andrew Gouldstone ◽  
Samuel Frank ◽  
Rifat Sipahi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Upper Limb ◽  
Movement Disorders ◽  
Healthy Subjects ◽  
Quantitative Assessment ◽  
Clinical Tests ◽  
Assessment Approach

Movement disorders associated with Essential Tremor (ET) and Parkinson’s disease (PD) can negatively impact use of the upper limb for many precision tasks, including handwriting. Both ET and PD can be assessed through clinical tests which are, however, relatively subjective. This assessment approach possesses inherent logistical and resolution limitations. To address this, here we present objective computerized metrics intended to assess and quantify the extent to which static writing samples display the effects of ET and PD. Specifically, these metrics are tested in their ability to measure tremor by comparing unaffected writing samples with those affected by artificially induced tremor on healthy subjects, and also by comparing healthy writing samples with symptomatic writing samples collected from PD patients reporting micrographia. Our findings indicate that the presented metrics can be utilized for assessment, leading to a toolset capable of objectively monitoring static handwriting changes associated with symptom variations in ET and/or PD patients.

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