The Relationship Between High Pulse Pressure and Low Ankle-Brachial Index. Potential Utility in Screening for Peripheral Artery Disease in Population-Based Studies

2015 ◽  
Vol 22 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera ◽  
Mark J. Sedler ◽  
Jadry A. Gruen ◽  
Kelsie J. Phelan ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Pulse Pressure ◽  
Ankle Brachial Index ◽  
Population Based ◽  
Potential Utility ◽  
Peripheral Artery ◽  
High Pulse Pressure ◽  
High Pulse ◽  
Artery Disease ◽  
The Relationship

scholarly journals The Association between Earlobe Crease (Frank’s Sign) and Abnormal Ankle-Brachial Index Determination Is Related to Age: A Population-Based Study

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera ◽  
Aldo F. Costa ◽  
Mauricio Zambrano ◽  
Mark J. Sedler
Keyword(s):  
Logistic Regression ◽  
Peripheral Artery Disease ◽  
Ankle Brachial Index ◽  
Heart Association ◽  
Population Based ◽  
Community Dwelling ◽  
Peripheral Artery ◽  
Probability Models ◽  
High Prevalence ◽  
Artery Disease

Background. Information on the association between earlobe crease (ELC) and peripheral artery disease is limited. We assessed this association in community-dwelling older adults. Study Design. A total of 294 Atahualpa residents aged ≥60 years were enrolled. ELC were visually identified by two raters. The ankle-brachial index (ABI), used as a surrogate of peripheral artery disease, was categorized using American Heart Association criteria. Using logistic regression and probability models, adjusted for demographics and cardiovascular risk factors, we assessed the relationship between ELC and abnormal ABI determinations, as well as the influence of age on this association. Results. ELC was identified in 141 (48%) individuals, and abnormal ABI determination was carried out in 56 (19%). The association between ELC and abnormal ABI was nonsignificant in logistic regression and probability models with individuals stratified according to their median age. Conclusions. The association between ELC and abnormal ABI determinations is probably attenuated by the high prevalence of both conditions in older persons. ELC might not be useful for identifying candidates for ABI determination.

scholarly journals Prevalence, Correlates, and Prognosis of Peripheral Artery Disease in Rural Ecuador—Rationale, Protocol, andPhase IResults of a Population-Based Survey: An Atahualpa Project-Ancillary Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Oscar H. Del Brutto ◽  
Mark J. Sedler ◽  
Robertino M. Mera ◽  
Pablo R. Castillo ◽  
Elizabeth H. Cusick ◽  
...  
Keyword(s):  
Phase I ◽  
Peripheral Artery Disease ◽  
Cardiovascular Health ◽  
Ankle Brachial Index ◽  
Vascular Diseases ◽  
Population Based ◽  
Test Reliability ◽  
Phase Iii ◽  
Peripheral Artery ◽  
Artery Disease

Background. Little is known on the prevalence of peripheral artery disease (PAD) in developing countries.Study design. Population-based study in Atahualpa. InPhase I, the Edinburgh claudication questionnaire (ECQ) was used for detection of suspected symptomatic PAD; persons with a negative ECQ but a pulse pressure ≥65 mmHg were suspected of asymptomatic PAD. InPhase II, the ankle-brachial index will be used to test reliability of screening instruments and to determine PAD prevalence. InPhase III, participants will be followed up to estimate the relevance of PAD as a predictor of vascular outcomes.Results. DuringPhase I, 665 Atahualpa residents aged ≥40 years were enrolled (mean age: 59.5 ± 12.6 years, 58% women). A poor cardiovascular health status was noticed in 464 (70%) persons of which 27 (4%) had a stroke and 14 (2%) had ischemic heart disease. Forty-four subjects (7%) had suspected symptomatic PAD and 170 (26%) had suspected asymptomatic PAD. Individuals with suspected PAD were older, more often women, and had a worse cardiovascular profile than those with nonsuspected PAD.Conclusions. Prevalence of suspected PAD in this underserved population is high. Subsequent phases of this study will determine whether prompt detection of PAD is useful to reduce the incidence of catastrophic vascular diseases in the region.

scholarly journals The relationship of renal function to segmental vascular stiffness, ankle-brachial index, and peripheral artery disease

2018 ◽  
Vol 20 (6) ◽  
pp. 1027-1035 ◽  
Author(s):  
Yueh-Hung Lin ◽  
Kuo-Tzu Sung ◽  
Cheng-Ting Tsai ◽  
Pei-Chen Wu ◽  
Yau-Huei Lai ◽  
...  
Keyword(s):  
Renal Function ◽  
Peripheral Artery Disease ◽  
Ankle Brachial Index ◽  
Vascular Stiffness ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Relationship Of ◽  
The Relationship

scholarly journals Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1911
Author(s):  
Agnieszka Zembron-Lacny ◽  
Wioletta Dziubek ◽  
Anna Tylutka ◽  
Eryk Wacka ◽  
Barbara Morawin ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Peripheral Artery Disease ◽  
Crucial Role ◽  
Reference Group ◽  
Ankle Brachial Index ◽  
Activated Macrophages ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females n = 17, males n = 42) aged 67.0 ± 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI ≤ 0.9 n = 43, ABI ≤ 0.5 n = 16). A total of 60 subjects aged 70.4 ± 5.5 years (females n = 42, males n = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 ± 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI ≤ 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects.

scholarly journals Hubungan Merokok dan Obesitas Sentral dengan Nilai Ankle-Brachial Index pada Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Maghfirah Savitri ◽  
Frans Wantania ◽  
Bisuk P. Sedli
Keyword(s):  
Peripheral Artery Disease ◽  
Health Care Providers ◽  
Significant Relationship ◽  
Central Obesity ◽  
Ankle Brachial Index ◽  
P Value ◽  
Care Providers ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

Abstract: Peripheral artery disease (PAD) is commonly found in the community but it is hard to detect in primary health care providers. Smoking and central obersity are the major risk factors in the development of PAD. One non-invasive and cheap method in screening for PAD is determining the ankle-brachial index (ABI). This study was aimed to provide an overview of the relationship between ABI and smoking and central obesity among students of Faculty of Medicine, Sam Ratulangi University. This was an analytical study with a cross sectional design using the ABI results of the students. There were 73 students as subjects; 26 non-smokers with no central obesity (36%), 15 smokers (20%), 21 with central obesity (29%), and 11 smokers with central obesity (15%). The age range of subjects was 18-23 year olds (young adult age). The Fisher’s exact test analysis of the relationship between smoking and PAD obtained a p-value of 0.267 (p>=0.05) and of the relationship between central obesity and PAD obtained a p-value of 0.016 (p<=0.05). In conclusion, there was a significant relationship between central obesity and ABI, albeit there was no significant relationship between smoking and ABI.Keywords: peripheral artery disease, ankle-brachial index, smoking, central obesity. Abstrak: Penyakit arteri perifer (PAP) banyak ditemukan pada masyarakat tetapi sulit terdeteksi di layanan kesehatan primer. Merokok dan obesitas sentral ialah faktor risiko yang berperan penting dalam perkembangan PAP. Salah satu metode pemeriksaan non invasif, murah, dan mudah untuk mendeteksi PAP ialah dengan menentukan nilai Ankle-Brachial Index (ABI). Penelitian ini bertujuan untuk mengetahui gambaran ABI serta hubungan merokok dan obesitas sentral dengan PAP pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Jenis penelitian ialah analitik dengan desain potong lintang menggunakan hasil pemeriksaan ABI. Hasil penelitian mendapatkan 73 mahasiswa sebagai subyek; 26 yang tidak merokok dan tidak obes sentral (36%), 15 yang merokok (20%), 21 yang obes sentral (29%), dan 11 yang obes sentral dan merokok (15%). Kisaran usia sampel yaitu 18-23 tahun (usia dewasa muda). Hasil uji Fisher’s exact terhadap hubungan merokok dengan PAP didapatkan nilai p=0,269 (p>=0,05) dan untuk obesitas sentral dengan PAP didapatkan nilai p=0,016 (p<=0,05). Simpulan penelitian ini ialah terdapat hubungan bermakna antara obesitas dengan nilai ABI, tetapi tidak terdapat hubungan bermakna antara merokok dengan nilai ABI.Kata kunci: penyakit arteri perifer, ankle-brachial index, merokok, obesitas sentral

scholarly journals Hubungan Merokok dan Obesitas Sentral dengan Nilai Ankle-Brachial Index pada Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Maghfirah Savitri ◽  
Frans Wantania ◽  
Bisuk P. Sedli
Keyword(s):  
Peripheral Artery Disease ◽  
Health Care Providers ◽  
Significant Relationship ◽  
Central Obesity ◽  
Ankle Brachial Index ◽  
P Value ◽  
Care Providers ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

Abstract: Peripheral artery disease (PAD) is commonly found in the community but it is hard to detect in primary health care providers. Smoking and central obersity are the major risk factors in the development of PAD. One non-invasive and cheap method in screening for PAD is determining the ankle-brachial index (ABI). This study was aimed to provide an overview of the relationship between ABI and smoking and central obesity among students of Faculty of Medicine, Sam Ratulangi University. This was an analytical study with a cross sectional design using the ABI results of the students. There were 73 students as subjects; 26 non-smokers with no central obesity (36%), 15 smokers (20%), 21 with central obesity (29%), and 11 smokers with central obesity (15%). The age range of subjects was 18-23 year olds (young adult age). The Fisher’s exact test analysis of the relationship between smoking and PAD obtained a p-value of 0.267 (p>=0.05) and of the relationship between central obesity and PAD obtained a p-value of 0.016 (p<=0.05). In conclusion, there was a significant relationship between central obesity and ABI, albeit there was no significant relationship between smoking and ABI.Keywords: peripheral artery disease, ankle-brachial index, smoking, central obesity. Abstrak: Penyakit arteri perifer (PAP) banyak ditemukan pada masyarakat tetapi sulit terdeteksi di layanan kesehatan primer. Merokok dan obesitas sentral ialah faktor risiko yang berperan penting dalam perkembangan PAP. Salah satu metode pemeriksaan non invasif, murah, dan mudah untuk mendeteksi PAP ialah dengan menentukan nilai Ankle-Brachial Index (ABI). Penelitian ini bertujuan untuk mengetahui gambaran ABI serta hubungan merokok dan obesitas sentral dengan PAP pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Jenis penelitian ialah analitik dengan desain potong lintang menggunakan hasil pemeriksaan ABI. Hasil penelitian mendapatkan 73 mahasiswa sebagai subyek; 26 yang tidak merokok dan tidak obes sentral (36%), 15 yang merokok (20%), 21 yang obes sentral (29%), dan 11 yang obes sentral dan merokok (15%). Kisaran usia sampel yaitu 18-23 tahun (usia dewasa muda). Hasil uji Fisher’s exact terhadap hubungan merokok dengan PAP didapatkan nilai p=0,269 (p>=0,05) dan untuk obesitas sentral dengan PAP didapatkan nilai p=0,016 (p<=0,05). Simpulan penelitian ini ialah terdapat hubungan bermakna antara obesitas dengan nilai ABI, tetapi tidak terdapat hubungan bermakna antara merokok dengan nilai ABI.Kata kunci: penyakit arteri perifer, ankle-brachial index, merokok, obesitas sentral

scholarly journals Pulse Pressure and Upstroke Time Are Useful Parameters for the Diagnosis of Peripheral Artery Disease in Patients With Normal Ankle Brachial Index

2016 ◽  
Vol 7 (5) ◽  
pp. 161-166 ◽  
Author(s):  
Shunsuke Kiuchi ◽  
Shinji Hisatake ◽  
Ippei Watanabe ◽  
Mikihito Toda ◽  
Takayuki Kabuki ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Pulse Pressure ◽  
Ankle Brachial Index ◽  
Peripheral Artery ◽  
Artery Disease
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