An experimental investigation was conducted on a single phase microchannel heat sink, in which the bottom surface of the microchannel was modified with hybrid micro-sandblasting of elliptical patterns (HSEP) and fully sandblasting (FS) to passively enhance the microchannel heat transfer performance. The dimension of the microchannel is measured as 26 mm (L) × 5mm (W) × 0.35 mm (H), which results in a hydraulic diameter of 654 μm. Deionized water was used as the coolant, and the Reynolds number range between 85 to 650 was tested. The experimental results show that fully sandblasting (FS) bottom surface of the microchannel only slightly improved the heat transfer performance. However, the modified surface with HSEP enhanced the heat transfer performance substantially, compared to the benchmark results obtained with the bare surface (BS) microchannel. The pressure drops of the HSEP increased slightly compared to the BS and FS, due to the flow resistance of the microstructures. The proposed surface for enhancement of heat transfer will be useful in many high heat flux engineering applications. In the future, this study will be further extended to two-phase microchannel heat transfer.