scholarly journals Drug-induced anaphylaxis—elicitors, mechanisms and diagnosis

2019 ◽  
Vol 28 (8) ◽  
pp. 327-329
Author(s):  
Margitta Worm ◽  
Theresa Hanschmann-Mohn ◽  
Kathrin Scherer Hofmeier ◽  
Victòria Cardona ◽  
Paul Turner ◽  
...  
Keyword(s):  
Drug Induced ◽  
International Guidelines ◽  
Provocation Tests ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Drugs are one of the major causes of anaphylaxis. For example 2346 cases of drug-induced anaphylaxis were reported to the anaphylaxis register as of March 2019. The most common triggers of drug-induced anaphylaxis were nonsteroidal anti-inflammatory drugs (NSAIDs; n = 902) and antibiotics (n = 721). Drug-induced anaphylaxis can be caused by IgE-dependent (e.g., penicillins) and IgE-independent mechanisms. Recently MRG-PX2 has been identified as a receptor for non-IgE-dependent mechanisms. Drug-induced anaphylaxis results more frequently in lethal reactions and is more commonly associated with cardiovascular symptoms. Also therapy refractory anaphylaxis is more frequently triggered by drugs. For the diagnosis of drug-induced anaphylaxis current national and international guidelines should be followed including provocation tests to avoid future reactions.

Drug-induced anaphylaxis in children: Nonsteroidal anti-inflammatory drugs and drug provocation test

2014 ◽  
Vol 2 (6) ◽  
pp. 825 ◽  
Author(s):  
Luis Felipe Ensina ◽  
Alex Eustaquio de Lacerda ◽  
Djanira Martins de Andrade ◽  
Ligia Machado ◽  
Inês Camelo-Nunes ◽  
...  
Keyword(s):  
Provocation Test ◽  
Drug Induced ◽  
Drug Provocation Test ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Sa1558 Risk of Non-Steroidal Anti-Inflammatory Drugs-Related Serious Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 150 (4) ◽  
pp. S1066
Author(s):  
Sakkarin Chirapongsathorn ◽  
Chayakrit Krittanawong ◽  
Ann M. Farrell ◽  
Mohammad H. Murad ◽  
Patrick Kamath
Keyword(s):  
Systematic Review ◽  
Liver Injury ◽  
Meta Analysis ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Rofecoxib-Induced Hepatotoxicity: A Forgotten Complication of the Coxibs

2006 ◽  
Vol 20 (5) ◽  
pp. 351-355 ◽  
Author(s):  
Brian Yan ◽  
Yvette Leung ◽  
Stefan J Urbanski ◽  
Robert P Myers
Keyword(s):  
Hepatic Injury ◽  
Hepatic Dysfunction ◽  
Cyclooxygenase 2 ◽  
Liver Histology ◽  
Cardiovascular Safety ◽  
Drug Induced ◽  
Severe Hepatotoxicity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Rofecoxib is a member of the coxib family of nonsteroidal anti-inflammatory drugs that selectively inhibit cyclooxygenase-2. Although the coxibs are generally well-tolerated, rofecoxib was recently withdrawn from the market due to concerns regarding cardiovascular safety. Rare cases of hepatic injury attributable to the coxibs have been reported. In the present study, two additional cases of severe hepatotoxicity are described in patients with cholestatic symptoms and abnormal liver biochemistry, shortly following the initiation of rofecoxib for arthritic complaints. In both cases, liver histology was compatible with drug-induced hepatotoxicity, and rapid clinical and biochemical improvements were observed following rofecoxib discontinuation. With new coxibs and expanding indications on the horizon, physicians in all areas of practice must be aware of this disorder and consider it in any patient who develops hepatic dysfunction after taking a coxib.

scholarly journals Ketoprofen, an emerging photoallergen

2014 ◽  
Vol 83 (3) ◽  
pp. 260-264
Author(s):  
Ewelina Bogumiła Zuba ◽  
Agnieszka Osmola-Mańkowska ◽  
Dorota Jenerowicz ◽  
Maciej Stawny ◽  
Magdalena Czarnecka-Operacz
Keyword(s):  
Contact Dermatitis ◽  
Positive Reaction ◽  
Topical Application ◽  
Clinical Importance ◽  
Drug Induced ◽  
Detailed Instruction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Introduction. Ketoprofen, which belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), is an emerging photoallergen. Especially its topical use may be a cause of drug-induced photosensitivity.Material and methods. We report two cases of photoallergic and one case of phototaggravated contact dermatitis due to topical ketoprofen application, confirmed by photopatch testing.Results. All patients presented positive reactions to ketoprofen at an irradiated site. Only one patient demonstrated a positive reaction to ketoprofen both at an irradiated and non-irradiated site.Conclusions. Photosensitive reactions due to topical application of ketoprofen being of significant clinical importance need to be properly diagnosed. It is crucial to provide patients with a detailed instruction how to protect photoexposed areas during therapy with ketoprofen.

scholarly journals Nonsteroidal Anti-Inflammatory Drug-Induced Severe Hyponatremia

Medicina ◽  
2012 ◽  
Vol 48 (12) ◽  
pp. 90 ◽  
Author(s):  
Mehmet Demir ◽  
Mehmet Horoz ◽  
Turgay Ulas ◽  
Mehmet Eren ◽  
Zafer Ercan
Keyword(s):  
Water Retention ◽  
Serum Sodium Level ◽  
Free Water ◽  
Inhibitory Effect ◽  
Severe Hyponatremia ◽  
Drug Induced ◽  
Water Excretion ◽  
Inflammatory Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Hyponatremia (serum sodium level, <135 mmol/L) occasionally may develop in the course of treatment with nonsteroidal anti-inflammatory drugs, which are usually used in daily clinical practice. Nonsteroidal anti-inflammatory drugs diminish the normal inhibitory effect of prostaglandins on the activity of antidiuretic hormone and can therefore reduce free water excretion, leading to water retention and induction or exacerbation of hyponatremia. In this report, we present a case of hyponatremia in a 78-year-old man who had received meloxicam, a nonsteroidal anti-inflammatory drug.

Drug-induced anaphylactic shock events

2020 ◽  
pp. 6-9
Author(s):  
Elena Galimova ◽  
Guzel Nurtdinova ◽  
Olga Kucher ◽  
Victoriya Muslimova
Keyword(s):  
Retrospective Analysis ◽  
Anaphylactic Shock ◽  
Case Histories ◽  
Drug Induced ◽  
Etiological Factors ◽  
Clinical Forms ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

This article presents a retrospective analysis of 86 case histories of patients with drug-induced anaphylactic shock. The main etiological factors of anaphylactic shock and clinical forms were identified. Certain groups of drugs that most commonly cause anaphylactic shock are determined: β-lactam antibiotics, non-steroidal anti-inflammatory drugs, vitamins, enzymes, and antienzymes.

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