Conflicts Between Non-Directive Counseling and Unbiased Patient Care: the Influence of Medical Students’ Personal Beliefs on Proposed Huntington’s Disease Genetic Testing Recommendations

Chorea manifests as involuntary, often contnuous, unpredictable, and involuntary dance-like movements. Patients with chorea are often unaware that they have involuntary movements. Others may try to incorporate the movement into a semipurposeful action (parakinesia). Chorea is usually worse with mental activity or emotion. Physical activity may also exacerbate chorea. The presence of “motor impersistence” is typical of chorea. Sometimes patients can also make unintentional sounds referred to as hyperkinetic dysarthria. Chorea disappears during sleep. Ballism is considered a type of chorea with a more proximal distribution and larger movements. Athetosis is a term formally used for chorea with slow writing movements in the distal limbs, but it is not considered a specific entity of chorea anymore. The most important genetic cause of chorea in adulthood is Huntington’s disease, and genetic testing should be considered as a first step in all patients with adult-onset chorea if no secondary cause is found.

Download Full-text

Huntington's disease confirmed by genetic testing in five african families

Movement Disorders ◽

10.1002/mds.870130420 ◽

1998 ◽

Vol 13 (4) ◽

pp. 726-730 ◽

Cited By ~ 13

Author(s):

E. Silber ◽

J. Kromberg ◽

J. A. Temlett ◽

A. Krause ◽

D. Saffer

Keyword(s):

Genetic Testing ◽

Huntington's Disease ◽

Huntington’S Disease ◽

African Families

Download Full-text

Risk Perception and Decision-making Processes in Candidates for Genetic Testing for Huntington’s Disease: An Interpretative Phenomenological Analysis

Journal of Health Psychology ◽

10.1177/1359105302007002398 ◽

2002 ◽

Vol 7 (2) ◽

pp. 131-144 ◽

Cited By ~ 81

Author(s):

Jonathan A. Smith ◽

Susan Michie ◽

Mike Stephenson ◽

Oliver Quarrell

Keyword(s):

Decision Making ◽

Genetic Testing ◽

Risk Perception ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Interpretative Phenomenological Analysis ◽

Phenomenological Analysis ◽

Decision Making Processes

Download Full-text

Predictors of psychological adjustment to genetic testing for Huntington's disease.

Health Psychology ◽

10.1037/0278-6133.16.1.36 ◽

1997 ◽

Vol 16 (1) ◽

pp. 36-50 ◽

Cited By ~ 60

Author(s):

Ann-Marie Codori ◽

Phillip R. Slavney ◽

Candace Young ◽

Diana L. Miglioretti ◽

Jason Brandt

Keyword(s):

Genetic Testing ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Psychological Adjustment

Download Full-text

Ethical Issues and Policy Analysis for Genetic Testing: Huntington's Disease as a Paradigm for Diseases with a Late Onset

Human Reproduction & Genetic Ethics ◽

10.1179/hrge.11.2.e35336gt18776032 ◽

2005 ◽

Vol 11 (2) ◽

pp. 28-34 ◽

Cited By ~ 10

Author(s):

Anjali Lilani

Keyword(s):

Genetic Testing ◽

Policy Analysis ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Ethical Issues ◽

Late Onset

Download Full-text

Prenatal and Preimplantation Genetic Diagnosis of Huntington's Disease

10.21926/obm.neurobiol.2101085 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Joep P.M. Geraedts ◽

Keyword(s):

At Risk ◽

Genetic Testing ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Preimplantation Genetic Diagnosis ◽

Genetic Diagnosis ◽

Preimplantation Genetic Testing ◽

Dominant Disease ◽

Pros And Cons ◽

Disease Free

Huntington’s disease (HD) is an autosomal dominant disease that immensely impacts the affected families. However, the transmission of the disease from carriers to their offspring could be prevented. Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are the only two available reproductive options for the carriers at risk to have disease-free children. PND for HD could be done through two kinds of genetic testing: direct and indirect. The same approaches are available for preimplantation genetic testing. In addition, a third alternative is nondisclosure testing, which is only available in the case of PGD. The pros and cons of different approaches are discussed. However, only a relatively few at-risk parents opt for PND and PGD. Furthermore, compared to PND, PGD is even more seldom opted for as a reproductive option.

Download Full-text