Development and In Vitro Evaluation of Polymeric Responsive Release Matrix Type Transdermal Patches of Two Anti-asthmatic Drugs

2020 ◽  
Author(s):  
Muhammad Yousuf ◽  
Mahmood Ahmad ◽  
Muhammad Naeem ◽  
Muhammad Khalid Khan ◽  
Barkat Ali Khan
Keyword(s):  
Matrix Type ◽  
In Vitro Evaluation ◽  
Transdermal Patches

In Vitro Evaluation of Transdermal Patches Containing Capsaicin Marketed in Bosnia and Herzegovina

2019 ◽  
pp. 559-562
Author(s):  
A. Uzunovic ◽  
M. Dacic ◽  
Z. Ademovic ◽  
S. Osmancevic ◽  
S. Pilipovic ◽  
...  
Keyword(s):  
Bosnia And Herzegovina ◽  
In Vitro Evaluation ◽  
Transdermal Patches

Formulation development of matrix type transdermal patches containing mefenamic acid: physicochemical characterization and in vitro release evaluation

2017 ◽  
Vol 148 (7) ◽  
pp. 1215-1222 ◽  
Author(s):  
Jirapornchai Suksaeree ◽  
Kotchakorn Piamsap ◽  
Supawan Paktham ◽  
Tichakorn Kenprom ◽  
Chaowalit Monton ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Formulation Development ◽  
Matrix Type ◽  
Transdermal Patches ◽  
Vitro Release

Development of Acrylic Matrix Type Ketoprofen Patch

2012 ◽  
Vol 506 ◽  
pp. 533-536
Author(s):  
Nanthida Wonglertnirant ◽  
S. Tipwichai ◽  
Praneet Opanasopit ◽  
Theerasak Rojanarata ◽  
Suwannee Panomsuk ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Pressure Sensitive Adhesive ◽  
Drug Release Rate ◽  
Matrix Type ◽  
Adhesive Matrix ◽  
Pressure Sensitive ◽  
Transdermal Patches ◽  
Significant Difference

Ketoprofen transdermal patches (KTPs) were fabricated using an acrylic pressure sensitive adhesive (PSA) polymer. The influence of different factors (amount of PSA, drug content, and pressure applying on the backing membrane during preparation) on the characteristics of ketoprofen patch (thickness, W/A ratio, and adhesiveness of matrix film) and in vitro drug release behavior were investigated. The results revealed the successful fabrication and a good physical appearance of KTPs using acrylic PSA. Microscopic observations, FTIR spectra, and DSC thermograms were permitted to demonstrate that the drug was dispersed molecularly in the polymer. As the amount of PSA in the adhesive matrix was increased, the release rate of ketoprofen was decreased. Contrarily, the drug release rate was increased corresponding to the increase of ketoprofen content in the adhesive matrix. There was no significant difference in the release rate when the pressure applying on the backing membrane was varied. The kinetic of ketoprofen release from acrylic matrix type transdermal patches followed the Higuchis diffusion model.

Design and Development of Propranolol Hydrochloride Transdermal Patches: In Vitro and Ex Vivo Characterization

2020 ◽  
Vol 3 (1) ◽  
pp. 01-08
Author(s):  
Chinthakindi Shravya
Keyword(s):  
Drug Release ◽  
Moisture Absorption ◽  
Ex Vivo ◽  
Skin Permeation ◽  
Diffusion Mechanism ◽  
Propranolol Hydrochloride ◽  
Matrix Type ◽  
Transdermal Patches ◽  
Percent Moisture

The main aim of this investigation is to design and develop matrix type transdermal patches of Propranolol Hydrochloride which is an anti-hypertensive drug. These matrix type transdermal patches were prepared by “Solvent Casting Technique” using drug, HPMC E15 and Eudragit L 100 in the ratio of 1:6, 1:6.5, 1:7, 1:7.5, 1:8, 1:8.5, 1:9, 1:9.5. All formulations carried 20%v/w of PEG-600 as plasticizer. The prepared patches were characterized for various physicochemical parameters like weight, thickness, folding endurance, drug content, percent moisture content, percent moisture absorption, in vitro drug release and ex vivo permeation. Among this 1:9 ratio was found to be an Optimized formulation and patches were prepared by using permeation enhancers (lemon grass oil, Eucalyptus oil, and clove oil). The cumulative amount of drug release in 12hrs for F7 formulation showed maximum and used for that formulation skin permeation on Goat abdominal skin. FTIR studies show no interaction between drug, polymer and other excipients. The drug permeation kinetics followed “First order” and “zero order” profile with diffusion mechanism.

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