Focusing on international health issues in adolescent medicine, this issue of Adolescent Medicine: State of the Art Reviews is a stand-alone reference and practice tool with evidence-based reviews that detail advances in the diagnosis and management of a wide range of health problems affecting adolescents. Topics in International Health Issues in Adolescents include "Adolescent Health in an International Context: The Challenge of Sexual and Reproductive Health in Sub-Saharan Africa," "Poverty and Inequity in Adolescent Health," "Obesity and Nutrition in Adolescents," "Adolescent Substance Abuse: An International Perspective," "Burden of Non-sexually Transmitted Infections on Adolescent Health and Development in the Developing World," "Addressing Ethical Dilemmas in the Clinical Care of Adolescents: An International View," "Children, Adolescents, and War: The Systematic Engagement of Youth in Collective Violence," "Chronic Illness and Disability in Adolescents: An International Perspective," "Culture and Youth Development," "A Global Perspective of Adolescent Sexual and Reproductive Health: Context Matters," and "The Mongolia Experience: Transitioning Within Transition."