Cyclobutane Dimer

2012 ◽  
Keyword(s):  
Cyclobutane Dimer

scholarly journals Base Pair Opening in a Deoxynucleotide Duplex Containing a cis-syn Thymine Cyclobutane Dimer Lesion

Biochemistry ◽  
2013 ◽  
Vol 52 (51) ◽  
pp. 9275-9285 ◽  
Author(s):  
Belinda B. Wenke ◽  
Leah N. Huiting ◽  
Elisa B. Frankel ◽  
Benjamin F. Lane ◽  
Megan E. Núñez
Keyword(s):  
Base Pair ◽  
Cyclobutane Dimer ◽  
Base Pair Opening

Production of cis–syn thymine–thymine cyclobutane dimer oligonucleotide in the presence of acetone photosensitizer

2006 ◽  
Vol 353 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Wanmeng Mu ◽  
Qingkai Han ◽  
Zhaofeng Luo ◽  
Yuzhen Wang
Keyword(s):  
Cyclobutane Dimer

ChemInform Abstract: A NEW HETEROCYCLIC CAGE RING SYSTEM, PREPARATION OF THE CIS-CYCLOBUTANE DIMER OF DIBENZO(A,D)CYCLOHEPTEN-5-ONE

1975 ◽  
Vol 6 (44) ◽  
pp. no-no
Author(s):  
J. ROKACH ◽  
Y. GIRARD ◽  
J. G. ATKINSON
Keyword(s):  
Ring System ◽  
Cyclobutane Dimer

scholarly journals Escherichia coli DNA Polymerase III Can Replicate Efficiently past a T-T cis-syn Cyclobutane Dimer if DNA Polymerase V and the 3′ to 5′ Exonuclease Proofreading Function Encoded by dnaQ Are Inactivated

2002 ◽  
Vol 184 (10) ◽  
pp. 2674-2681 ◽  
Author(s):  
Angela Borden ◽  
Paul I. O'Grady ◽  
Dominique Vandewiele ◽  
Antonio R. Fernández de Henestrosa ◽  
Christopher W. Lawrence ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dna Polymerase ◽  
Wild Type ◽  
Lesion Bypass ◽  
Base Pairs ◽  
Pol V ◽  
Pol I ◽  
Cyclobutane Dimer ◽  
Dna Polymerase V ◽  
Pol Iii

ABSTRACT Although very little replication past a T-T cis-syn cyclobutane dimer normally takes place in Escherichia coli in the absence of DNA polymerase V (Pol V), we previously observed as much as half of the wild-type bypass frequency in Pol V-deficient (ΔumuDC) strains if the 3′ to 5′ exonuclease proofreading activity of the Pol III ε subunit was also disabled by mutD5. This observation might be explained in at least two ways. In the absence of Pol V, wild-type Pol III might bind preferentially to the blocked primer terminus but be incapable of bypass, whereas the proofreading-deficient enzyme might dissociate more readily, providing access to bypass polymerases. Alternatively, even though wild-type Pol III is generally regarded as being incapable of lesion bypass, proofreading-impaired Pol III might itself perform this function. We have investigated this issue by examining dimer bypass frequencies in ΔumuDC mutD5 strains that were also deficient for Pol I, Pol II, and Pol IV, both singly and in all combinations. Dimer bypass frequencies were not decreased in any of these strains and indeed in some were increased to levels approaching those found in strains containing Pol V. Efficient dimer bypass was, however, entirely dependent on the proofreading deficiency imparted by mutD5, indicating the surprising conclusion that bypass was probably performed by the mutD5 Pol III enzyme itself. This mutant polymerase does not replicate past the much more distorted T-T (6-4) photoadduct, however, suggesting that it may only replicate past lesions, like the T-T dimer, that form base pairs normally.

Photochemical behavior of some α, β-unsaturated lactams. Dependence of reaction path on multiplicity

1969 ◽  
Vol 47 (15) ◽  
pp. 2781-2786 ◽  
Author(s):  
E. Cavalieri ◽  
S. Horoupian
Keyword(s):  
Excited State ◽  
Spectral Properties ◽  
Reaction Path ◽  
Triplet Excited State ◽  
Excited Singlet ◽  
Cleavage Reaction ◽  
Dimer Formation ◽  
Cyclobutane Dimer ◽  
Direct Irradiation ◽  
Cyclobutane Dimers

Whereas direct irradiation (2537 Å) of 5,6-dihydro-4,6,6-trimethyl-2(1H)-pyridone 1 (1a) produced almost exclusively the cleavage products 2 and 3, the acetophenone sensitized reaction (3500 Å) gave a single cyclobutane dimer. In contrast, direct (2537 Å) or sensitized (acetophenone, 3500 Å) irradiation of the homo derivative 7 of compound 1 gave approximately the same mixture of two cyclobutane dimers. It was thus demonstrated that dimer formation proceeded by way of a triplet excited state and that the cleavage reaction most probably occurred via an excited singlet state.A structure for each cyclobutane dimer in the seven-membered series was proposed on the basis of its spectral properties.

Synthesis and Photochemical Cleavage of Cis-Syn Pyrimidine Cyclobutane Dimer Analogs

1995 ◽  
Vol 60 (3) ◽  
pp. 624-631 ◽  
Author(s):  
David J. Fenick ◽  
Heather S. Carr ◽  
Daniel E. Falvey
Keyword(s):  
Cyclobutane Dimer ◽  
Photochemical Cleavage

P V.5 Behavior of RNA polymerase II at a cyclobutane dimer in DNA: Effect of sequence context

1997 ◽  
Vol 379 (1) ◽  
pp. S35
Author(s):  
Silvia Tornaletti ◽  
Brian Donahue ◽  
Daniel Reines ◽  
Philip Hanawalt
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Sequence Context ◽  
Cyclobutane Dimer

Triplet Excited Fluoroquinolones as Mediators for Thymine Cyclobutane Dimer Formation in DNA

2007 ◽  
Vol 111 (25) ◽  
pp. 7409-7414 ◽  
Author(s):  
Virginie Lhiaubet-Vallet ◽  
M. Consuelo Cuquerella ◽  
Jose V. Castell ◽  
Francisco Bosca ◽  
Miguel A. Miranda
Keyword(s):  
Dimer Formation ◽  
Cyclobutane Dimer
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