Level of initial blood pressure and subsequent development of essential hypertension

1962 ◽  
Vol 10 (3) ◽  
pp. 416-423 ◽  
Author(s):  
Samuel I. Kooperstein ◽  
Arthur Schifrin ◽  
Thomas J. Leahy
2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
J. Richard Jennings ◽  
Alicia F. Heim

Accumulating evidence from animal models and human studies of essential hypertension suggest that brain regulation of the vasculature is impacted by the disease. Human neuroimaging findings suggest that the brain may be an early target of the disease. This observation reinforces earlier research suggesting that psychological factors may be one of the many contributory factors to the initiation of the disease. Alternatively or in addition, initial blood pressure increases may impact cognitive and/or affective function. Evidence for an impact of blood pressure on the perception and experience of affect is reviewed vis-a-vis brain imaging findings suggesting that such involvement in hypertensive individuals is likely.


2008 ◽  
Vol 74 (8) ◽  
pp. 761-766 ◽  
Author(s):  
Om P. Sharma ◽  
Michael F. Oswanski ◽  
Jamal Rabbi ◽  
Gregory M. Georgiadis ◽  
Sherry K. Lauer ◽  
...  

Patients with pelvic fractures (PF) have high incidences of associated injuries and mortality. To identify patients with PF at the highest risk for mortality on admission to a Level I trauma center, investigators analyzed 566 PF in 12,128 patients (1996 to 2005). PF were categorized on arrival as high risk (HR) or low risk (LR) by initial blood pressure, examination, radiographs, and CT. HR PF included open fractures, open-book injuries, PF 4 or greater abbreviated injury score, and hypotension (89 mmHg or less systolic blood pressure); all other cases were categorized as LR PF. Patients with PF had 6 per cent (35 of 566) mortality compared with 3 per cent (300 of 11,529) without PF. Mortality was 24 per cent (25 of 103) in HR PF, including 11 per cent (one of nine) of open fractures, 25 per cent (12 of 49) of open-book injuries, 23 per cent (14 of 62) of 4 or greater abbreviated injury score, and 33 per cent (20 of 60) of hypotensive patients compared with 3 per cent (13 of 454) of LR PF. Compared with LR PF, patients with HR PF were younger (43.5 vs 53.8 years) with higher injury severity scores (28.7 vs 11.9) and longer hospital stays (10.6 vs 7.4 days). PF mortality remains high despite treatment in a Level I trauma center. Trauma mechanism, initial blood pressure, pelvic radiography, and CT can be used to predict a patient's mortality risk.


Resuscitation ◽  
2012 ◽  
Vol 83 ◽  
pp. e92
Author(s):  
Sarah Perman ◽  
Anne Grossestreuer ◽  
Marion Leary ◽  
Anthony Napoli ◽  
Maria Beylin ◽  
...  

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