Effect of dopamine and dobutamine on regional blood flow, myocardial oxygen consumption and high energy phosphate compounds during cardiopulmonary bypass

1981 ◽  
Vol 47 ◽  
pp. 416
Author(s):  
Stanley Einzig ◽  
John E. Foker ◽  
Herbert B. Ward ◽  
Richard W. Bianco ◽  
Barbara Borgwardt ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Cardiopulmonary Bypass ◽  
Myocardial Oxygen Consumption ◽  
Regional Blood Flow ◽  
High Energy ◽  
High Energy Phosphate ◽  
Phosphate Compounds

scholarly journals Effects of MK-801 and NBQX on Acute Recovery of Piglet Cerebral Metabolism after Hypothermic Circulatory Arrest

1994 ◽  
Vol 14 (1) ◽  
pp. 156-165 ◽  
Author(s):  
Mitsuru Aoki ◽  
Fumikazu Nomura ◽  
Michael E. Stromski ◽  
Miles K. Tsuji ◽  
James C. Fackler ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Cardiopulmonary Bypass ◽  
Circulatory Arrest ◽  
High Energy ◽  
Hypothermic Circulatory Arrest ◽  
Cerebral Oxygen ◽  
High Energy Phosphates ◽  
Mk 801

Brain protection during open heart surgery in the neonate and infant remains inadequate. Effects of the excitatory neurotransmitter antagonists MK-801 and NBQX on recovery of brain cellular energy state and metabolic rates were evaluated in 34 4-week-old piglets (10 MK-801, 10 NBQX, 14 controls) undergoing cardiopulmonary bypass and hypothermic circulatory arrest at 15°C nasopharyngeal temperature for 1 h, as is used clinically for repair of congenital heart defects. MK-801 (dizocilpine) (0.75 mg/kg) or NBQX [2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo( F)quinoxaline] (25 mg/kg) was given intravenously before cardiopulmonary bypass. Equivalent doses were placed in the cardiopulmonary bypass prime plus continuous infusions after reperfusion (0.15 mg kg−1h−1 and 5 mg kg−1h−1). Changes in high-energy phosphate concentrations and pH were analyzed by magnetic resonance spectroscopy in 17 animals until 225 min after reperfusion. Cerebral blood flow determined by radioactive microspheres as well as cerebral oxygen and glucose consumption were studied in 17 other animals. Cerebral blood flow and oxygen consumption were depressed relative to control by both MK-801 and NBQX at baseline. Recovery of phosphocreatine (p = 0.010), ATP (p = 0.030), and intracellular pH (p = 0.004) was accelerated by MK-801 and retarded by NBQX over the 45 min of rewarming reperfusion and the first hour of normothermic reperfusion. The final recovery of ATP at 3 h and 45 min reperfusion was significantly reduced by NBQX (46 ± 26% baseline, mean ± SD) versus control (81 ± 19%) and MK-801 (75 ± 8%) (p = 0.030). Cerebral oxygen consumption recovered to 105 ± 30% baseline in group MK-801 and 94 ± 31% in control but only to 61 ± 22% in group NBQX (p = 0.070). Cerebral blood flow stayed significantly lower in group NBQX relative to control. Thus, MK-801 accelerates recovery of cerebral high-energy phosphates and metabolic rate after cardiopulmonary bypass and hypothermic circulatory arrest in the immature animal. At the dosage used NBQX exerts an adverse effect.

Alteration in myocardial oxygen balance during exercise after beta-adrenergic blockade in dogs

1980 ◽  
Vol 49 (1) ◽  
pp. 28-33 ◽  
Author(s):  
G. R. Heyndrickx ◽  
J. L. Pannier ◽  
P. Muylaert ◽  
C. Mabilde ◽  
I. Leusen
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Oxygen Consumption ◽  
Myocardial Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Sinus ◽  
Myocardial Oxygen Consumption ◽  
Left Ventricular ◽  
Adrenergic Blockade ◽  
Oxygen Balance

The effects of beta-adrenergic blockade upon myocardial blood flow and oxygen balance during exercise were evaluated in eight conscious dogs, instrumented for chronic measurements of coronary blood flow, left ventricular pressure, aortic blood pressure, heart rate, and sampling of arterial and coronary sinus venous blood. The administration of propranolol (1.5 mg/kg iv) produced a decrease in heart rate, peak left ventricular (LV) dP/dt, LV (dP/dt/P, and an increase in LV end-diastolic pressure during exercise. Mean coronary blood flow and myocardial oxygen consumption were lower after propranolol than at the same exercise intensity in control conditions. The oxygen delivery-to-oxygen consumption ratio and the coronary sinus oxygen content were also significantly lower. It is concluded that the relationship between myocardial oxygen supply and demand is modified during exercise after propranolol, so that a given level of myocardial oxygen consumption is achieved with a proportionally lower myocardial blood flow and a higher oxygen extraction.

DIVERSITY OF METABOLIC PATTERNS IN HUMAN BRAIN TUMORS?I. HIGH ENERGY PHOSPHATE COMPOUNDS AND BASIC COMPOSITION

1977 ◽  
Vol 29 (6) ◽  
pp. 959-977 ◽  
Author(s):  
O. H. Lowry ◽  
S. J. Berger ◽  
M. M.-Y. Chi ◽  
J. G. Carter ◽  
A. Blackshaw ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
High Energy ◽  
High Energy Phosphate ◽  
Basic Composition ◽  
Human Brain Tumors ◽  
Phosphate Compounds
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