A clinical and family study of hereditary proconvertin (factor VII) deficiency

1964 ◽  
Vol 37 (2) ◽  
pp. 172-181 ◽  
Author(s):  
Charles A. Hall, ◽  
Samuel I. Rapaport ◽  
Sara B. Ames ◽  
Jean A. DeGroot ◽  
Edward S. Allen ◽  
...  
Keyword(s):  
Family Study ◽  
Factor Vii ◽  
Factor Vii Deficiency

Severe Hereditary Deficiency of Factor VII during Pregnancy

1970 ◽  
Vol 24 (01/02) ◽  
pp. 146-151 ◽  
Author(s):  
U Seligsohn ◽  
M. R Peyser ◽  
R Toaff ◽  
M Shani ◽  
B Ramot
Keyword(s):  
Family Study ◽  
Umbilical Vein ◽  
Factor Vii ◽  
Autosomal Gene ◽  
Factor Level ◽  
Homozygous State ◽  
Factor Vii Deficiency ◽  
The Family ◽  
Mild Deficiency ◽  
Partial Factor

SummaryIn normal pregnant women factor VII level is increased. This may also be observed in women with hereditary partial factor VII deficiency.In a 38 year old woman with severe hereditary factor VII deficiency no change of the factor level was observed during pregnancy. The patient underwent two uneventful caesarian sections because of placenta praevia and transverse lie of the fetus.During the second caesarian section factor VII level was simultaneously determined in blood obtained from the antecubital and uterine veins and from the umbilical vein and artery. Factor VII levels in the umbilical vessels were similar and exceeded the levels observed in the mother’s vessels. In 3 control patients similar examinations were performed during caesarian sections but reversed ratios of factor VII levels were observed. These data seem to prove that factor VII does not cross the placenta.In the family study 2 siblings were found to have severe factor VII deficiency whereas several other members had either normal or partial deficient levels. The results obtained support again the assumption that factor VII deficiency is inherited by an autosomal gene that in the homozygous state is manifested by severe factor VII deficiency and in the heterozygous state by mild deficiency or normal factor VII levels.

Inherited Factor VII Deficiency: Genetics and Molecular Pathology

1995 ◽  
Vol 74 (01) ◽  
pp. 313-321 ◽  
Author(s):  
Edward G D Tuddenham ◽  
Susan Pemberton ◽  
David N Cooper
Keyword(s):  
Molecular Pathology ◽  
Factor Vii ◽  
Factor Vii Deficiency

Two Typical Hereditary Charts of Congenital Factor VII Deficiency

1961 ◽  
Vol 05 (01) ◽  
pp. 087-092 ◽  
Author(s):  
F. J Cleton ◽  
E. A Loeliger
Keyword(s):  
Factor Vii ◽  
Autosomal Gene ◽  
Homozygous State ◽  
Recessive Character ◽  
Factor Vii Deficiency ◽  
Complete Penetrance ◽  
Coagulation Defect ◽  
Haemorrhagic Diathesis ◽  
Intermediate Expression ◽  
Congenital Factor

SummaryThe inheritance of congenital factor VII deficiency was investigated in 2 unrelated families. Out of 68 individuals, 4 (3 proven and 1 highly probable) were found to have severe factor VII deficiency (<C 0.1% factor VII), and 29 appeared to be heterozygotes (30—60% factor VII). The coagulation defect is due to an autosomal gene of intermediate expression and complete penetrance. The recessive character of the haemorrhagic diathesis due to the homozygous state for the abnormal gene is clearly demonstrated.

Paracetamol poisoning unmasking factor VII deficiency

2002 ◽  
Vol 14 (4) ◽  
pp. 441-443 ◽  
Author(s):  
Andrew P. Chilton ◽  
Tariq Hussain ◽  
Elwyn Elias
Keyword(s):  
Factor Vii ◽  
Paracetamol Poisoning ◽  
Factor Vii Deficiency

scholarly journals Efficacy and safety of recombinant factor VIIa preparation (NovoSeven) for patients with congenital factor VII deficiency

2006 ◽  
Vol 17 (6) ◽  
pp. 695-705 ◽  
Author(s):  
Hideji HANABUSA ◽  
Kazushige OYAMA ◽  
Satoshi WATANABE ◽  
Yuzuru SAKAKIBARA ◽  
Yuji HIRAMATSU ◽  
...  
Keyword(s):  
Recombinant Factor Viia ◽  
Factor Viia ◽  
Factor Vii ◽  
Efficacy And Safety ◽  
Factor Vii Deficiency ◽  
Congenital Factor
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