Immunoregulatory activity in supernatants from cultures of normal human trophoblast cells of the first trimester

1989 ◽  
Vol 161 (2) ◽  
pp. 446-453 ◽  
Author(s):  
Mrinal K. Sanyal ◽  
Charles J. Brami ◽  
Paul Bischof ◽  
Edwina Simmons ◽  
Eytan R. Barnea ◽  
...  
Keyword(s):  
First Trimester ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Normal Human ◽  
Human Trophoblast Cells

Characteristics of first trimester normal human trophoblast cells propagated in culture

Placenta ◽  
1993 ◽  
Vol 14 (4) ◽  
pp. A26 ◽  
Author(s):  
C.H. Graham ◽  
J.J. Lysiak ◽  
J.A. Irving ◽  
M. Letarte ◽  
J.R. MacDougall ◽  
...  
Keyword(s):  
First Trimester ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Normal Human ◽  
Human Trophoblast Cells

scholarly journals Kidney-Replenishing Herb Induces SOCS-3 Expression via ERK/MAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-12
Author(s):  
Chang-ying Xing ◽  
De-xiang Zhang ◽  
Sui-qi Gui ◽  
Min-fang Tao
Keyword(s):  
Mapk Pathway ◽  
Recurrent Miscarriage ◽  
First Trimester ◽  
Mek Inhibitor ◽  
Biological Functions ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Mitogen Activated Protein ◽  
Human Trophoblast Cells

Kidney-replenishing herb is a traditional medicine formula in China which has been widely used for clinical treatment of recurrent miscarriage. Our previous study showed that Kidney-replenishing herb could promote proliferation and inhibit apoptosis of the human first-trimester trophoblasts. In the present study, we further explored the potential mechanism and signal pathway of Kidney-replenishing herb on human trophoblast cells. Our research showed that Kidney-replenishing herb stimulated proliferation and reduced apoptosis of human trophoblast cells in vitro, and this appeared to be positive correlation with SOCS-3 transcription, suggesting that Kidney-replenishing herb regulated biological functions of human trophoblast cells by inducing SCOS-3 expression. Furthermore, the Kidney-replenishing herb treatment stimulated the phosphorylation of ERK1/2, and blocking the signaling pathway by mitogen-activated protein MAPK (MEK) inhibitor, U0126, inhibited Kidney-replenishing herb-induced SOCS-3 transcription, depressed proliferation, and promoted apoptosis of human trophoblasts. Kidney-replenishing herbs still induced ERK1/2 phosphorylation after SOCS-3 siRNA silence. Overexpression of SOCS-3 stimulated the proliferation of trophoblast. These findings suggest that SOCS-3 expression is induced by Kidney-replenishing herbs via activation of MAPK pathways, and this may possibly be involved in promoting human trophoblast cells growth which is contributed to embryo development.

scholarly journals Kisspeptin Regulation of Genes Involved in Cell Invasion and Angiogenesis in First Trimester Human Trophoblast Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99680 ◽  
Author(s):  
Víctor A. Francis ◽  
Aron B. Abera ◽  
Mushi Matjila ◽  
Robert P. Millar ◽  
Arieh A. Katz
Keyword(s):  
Cell Invasion ◽  
First Trimester ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Human Trophoblast Cells

scholarly journals Genome-wide expression profile of first trimester villous and extravillous human trophoblast cells

Placenta ◽  
2011 ◽  
Vol 32 (1) ◽  
pp. 33-43 ◽  
Author(s):  
R. Apps ◽  
A. Sharkey ◽  
L. Gardner ◽  
V. Male ◽  
M. Trotter ◽  
...  
Keyword(s):  
Expression Profile ◽  
First Trimester ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Genome Wide ◽  
Genome Wide Expression ◽  
Human Trophoblast Cells

Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended Lifespan

1993 ◽  
Vol 206 (2) ◽  
pp. 204-211 ◽  
Author(s):  
Charles H. Graham ◽  
Teresa S. Hawley ◽  
Robert C. Hawley ◽  
John R. MacDougall ◽  
Robert S. Kerbel ◽  
...  
Keyword(s):  
First Trimester ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Extended Lifespan ◽  
Human Trophoblast Cells
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